PZ703b
Based on 4 publication(s) in Google Scholar
PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research.
(Pink: Bcl-xL ligand (HY-184547); Blue: VHL ligand (HY-112078); Black: linker (HY-W014787)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.00%
- CAS 番号: 2471970-56-4
- 分子式: C80H102ClF3N10O11S4
- 分子量:1600.43
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 PZ703b
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生物活性
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VHL |
Bcl-xL |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLT-4 | IC50 |
15.9 nM
Compound: PZ703b
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Cytotoxicity against human MOLT-4 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human MOLT-4 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
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[PMID: 34533954] |
| Platelet | IC50 |
0.95 μM
Compound: PZ703b
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Cytotoxicity against platelets in human PRP assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against platelets in human PRP assessed as reduction in cell viability measured after 48 hrs by MTS assay
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[PMID: 34533954] |
| RS4-11 | IC50 |
11.3 nM
Compound: PZ703b
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Cytotoxicity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
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[PMID: 34533954] |
| RS4-11 | IC50 |
209 nM
Compound: PZ703b
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Cytotoxicity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs in presence of VHL-032 by MTS assay
Cytotoxicity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs in presence of VHL-032 by MTS assay
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[PMID: 34533954] |
PZ703b (0-1 μM, 24 h) synergistically inhibits bladder cancer cell proliferation with Mivebresib with a dose-dependent manner and induces apoptosis in bladder cancer cells via the mitochondrial pathway[1].
PZ703b (0-1 μM, 48 h) inhibits cell viability of MOLT-4 and RS4;11 cells with IC50 values of 15.9 and 11.3 nM, respectively[2].
PZ703b (10 nM, 48 h) induces rapid and durable BCL-XL degradation and apoptosis in MOLT-4 cells through the caspase-3 mediated pathway[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MOLT-4 cell line
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Concentration:10 nM
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Incubation Time:48 hours
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Result:Induced cell apoptosis of MOLT-4 cells.
化学情報
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CAS 番号 2471970-56-4
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性状 Solid
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分子量 1600.43
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分子式 C80H102ClF3N10O11S4
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Color White to off-white
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SMILES
ClC1=CC=C(C=C1)C2=C(C[C@](CNC(CCCCCCCCC(N[C@H](C(N3C[C@@H](C[C@H]3C(N[C@@H](C)C4=CC=C(C=C4)C5=C(N=CS5)C)=O)O)=O)C(C)(C)C)=O)=O)(CC2)C)CN6CCN(CC6)C7=CC=C(C=C7)C(NS(C8=CC(S(=O)(C(F)(F)F)=O)=C(C=C8)N[C@H](CCN9CCOCC9)CSC%10=CC=CC=C%10)(=O)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (4)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Minimizes Ex Vivo Reservoirs from Patients. [Abstract]2025 Mar 19;26(6):2772. PMID: 40141414 -
Biochem Biophys Res Commun
Mivebresib synergized with PZ703b, a novel Bcl-xl PROTAC degrader, induces apoptosis in bladder cancer cells via the mitochondrial pathway. [Abstract]2022 Oct 1:623:120-126. PMID: 35921705 -
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溶剤 & 溶解度
DMSO : 100 mg/mL (62.48 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Yi Xu, et al. Mivebresib synergized with PZ703b, a novel Bcl-xl PROTAC degrader, induces apoptosis in bladder cancer cells via the mitochondrial pathway. Biochem Biophys Res Commun. 2022 Oct 1;623:120-126. [Content Brief]
[2]. Pal P, et al. Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition. J Med Chem. 2021 Oct 14;64(19):14230-14246. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6248 mL | 3.1242 mL | 6.2483 mL | 15.6208 mL |
| 5 mM | 0.1250 mL | 0.6248 mL | 1.2497 mL | 3.1242 mL | |
| 10 mM | 0.0625 mL | 0.3124 mL | 0.6248 mL | 1.5621 mL | |
| 15 mM | 0.0417 mL | 0.2083 mL | 0.4166 mL | 1.0414 mL | |
| 20 mM | 0.0312 mL | 0.1562 mL | 0.3124 mL | 0.7810 mL | |
| 25 mM | 0.0250 mL | 0.1250 mL | 0.2499 mL | 0.6248 mL | |
| 30 mM | 0.0208 mL | 0.1041 mL | 0.2083 mL | 0.5207 mL | |
| 40 mM | 0.0156 mL | 0.0781 mL | 0.1562 mL | 0.3905 mL | |
| 50 mM | 0.0125 mL | 0.0625 mL | 0.1250 mL | 0.3124 mL | |
| 60 mM | 0.0104 mL | 0.0521 mL | 0.1041 mL | 0.2603 mL |
PZ703b 関連分類
HY-115718 関連分類
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