RO314724
RO314724 is a selective MMP-1 inhibitor. RO314724 chelates to the catalytic zinc ion within the active site of MMP-1 and forms a stable complex with MMP-1. RO314724 can be used for the research of osteoarthritis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 112105-54-1
- 分子式: C19H35N3O6
- 分子量:401.50
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
MMP-1 |
体外実験
RO314724 binds to the active site of MMP-1 with a Glide docking score of -7.907 kcal/mol, chelating the catalytic zinc ion via its hydroxamate group[1].
RO314724 forms a stable complex with MMP-1 over 50 ns of molecular dynamics simulation, with a binding free energy of -36.99 kcal/mol, supported by key active site residue interactions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 112105-54-1
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分子量 401.50
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分子式 C19H35N3O6
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SMILES
C[C@@H](C(OCC)=O)NC([C@H](CC(C)C)NC([C@@H](CC(NO)=O)CC(C)C)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
RO314724 関連分類
HY-115373 関連分類
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