ST7710AA1
ST7710AA1 (compound 1l) is a potent PARP-1 inhibitor with an IC50 value of 0.07 µM. ST7710AA1 shows an antiproliferative activity. ST7710AA1 shows anticancer activity.
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- CAS 番号: 1542067-20-8
- 分子式: C20H22N4O
- 分子量:334.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
PARP-1 0.07 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
2.9 μM
Compound: 1l, ST7710AA1
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Antiproliferative activity against human A2780 cells after 72 hrs by SRB assay
Antiproliferative activity against human A2780 cells after 72 hrs by SRB assay
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[PMID: 24398383] |
| CAPAN-1 | IC50 |
22.04 μM
Compound: 1l, ST7710AA1
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Antiproliferative activity against BRCA2 gene mutated human Capan1 cells after 72 hrs by SRB assay
Antiproliferative activity against BRCA2 gene mutated human Capan1 cells after 72 hrs by SRB assay
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[PMID: 24398383] |
| HCC1937 | IC50 |
19.43 μM
Compound: 1l, ST7710AA1
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Antiproliferative activity against BRCA1 gene mutated human HCC1937 cells after 72 hrs by SRB assay
Antiproliferative activity against BRCA1 gene mutated human HCC1937 cells after 72 hrs by SRB assay
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[PMID: 24398383] |
| HeLa | EC50 |
400 nM
Compound: 1l, ST7710AA1
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Inhibition of PARP-1 in human HeLa cells assessed as decrease of H2O2-induced PARylation after 3 hrs by fluorescence assay
Inhibition of PARP-1 in human HeLa cells assessed as decrease of H2O2-induced PARylation after 3 hrs by fluorescence assay
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[PMID: 24398383] |
体外実験
ST7710AA1 (compound 1l) (0-200 µM; 72 h) shows antiproliferative with IC50s of 19.43, 22.04 µM for HCC1937, Capan 1, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1542067-20-8
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分子量 334.41
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分子式 C20H22N4O
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SMILES
O=C(N1C=CC2=C1N=C(C=C2)C3=CC=C(C=C3)CN4CCCCC4)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ST7710AA1 関連分類
HY-117423 関連分類
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