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製品番号: HY-187536

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SYA16263

SYA16263 is a dopamine D₂ receptor (D₂R) and serotonin 1A receptor (5-HT_1AR) ligand, with K_i values of 1.24 nM and 0.67 nM for D₂R and 5-HT_1AR, respectively. SYA16263 stabilizes the inactive conformation of D₂R and 5-HT_1AR via interactions with specific amino acid residues in their orthosteric binding pockets, thereby blocking downstream signal transduction. SYA16263 can be used in research related to schizophrenia and psychosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 129281-28-3
分子式: C₁₉H₂₄FN₃
分子量:313.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SYA16263 構造式

CAS 番号: 129281-28-3

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価格（税別）

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数量

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
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参考文献
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生物活性

製品説明

IC₅₀ & Target^[1]

Dopamine D2 receptor

5-HT1AR

5-HT Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

SYA16263 (compound 36) (0.1 nM-10 μM; 90 min) exhibits specific binding activity to dopamine D2 receptors and 5-HT1A receptors in cell membrane fragments stably expressing specific receptors (including CHO, HEK T*, HET T, fibroblast), with K_i values of 1.24 nM and 0.67 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

SYA16263 (Compound 36) (intraperitoneal injection; single administration) exerts an inhibitory effect on abnormal climbing behavior in the apomorphine (HY-12723)-induced mouse climbing model^[1].
SYA16263 (0.632-1.896 mg/kg; i.p.; single administration; 60-66 min) does not induce extrapyramidal side effects in the rat catalepsy test model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male, ~6 weeks old, 133-153 g)^[1]
Dosage:

0.632, 1.264, 1.896 mg/kg
Administration:

i.p.; single administration; 60, 63, 66 min
Result:

Did not induce extrapyramidal side effects

化学情報

CAS 番号 129281-28-3
分子量 313.41
分子式 C₁₉H₂₄FN₃
SMILES

FC(C=C1)=CC=C1CCCCN(CC2)CCN2C3=CC=CC=N3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Gonela UM, et al. Structure-Affinity Relationship Optimization of SYA16263 Yields New Ligands with Improved Receptor Affinity and Antipsychotic-Like Properties. ACS Omega. 2026 Jul 20;11(31):46009-46029.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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SYA16263

5-HT Receptor アイソフォーム固有の製品をすべて表示