TBC3486
TBC3486 is a highly selective integrin α4β1 inhibitor. TBC3486 acts as a chemosensitizer to enhance the sensitivity of leukemia cells to chemotherapy. TBC3486 exhibits efficacy in preclinical models of integrin α4-dependent inflammatory and autoimmune diseases, including a mouse model of autoimmune encephalomyelitis. TBC3486 can be used for the research of precursor B-cell acute lymphoblastic leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 247044-77-5
- 分子式: C27H31N3O6S2
- 分子量:557.68
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
TBC3486 (5-25 μM; 4 days) dose-dependently reduces adhesion of pre-B-ALL LAX7R cells to OP9 stromal cells[1].
TBC3486 (25 μM; 4 days) specifically downregulates integrin α4 expression in pre-B-ALL LAX7R cells without altering integrin α5 or integrin α6 expression[1].
TBC3486 (25 μM; 2 days) significantly reduces adhesion of pre-B-ALL LAX7R, ICN3, and SFO3 cells to human VCAM-1, with the greatest effect observed in CD49d-high LAX7R cells[1].
TBC3486 (25 μM; 2 days) does not affect the viability of pre-B-ALL LAX7R, ICN3, or SFO3 cells[1].
TBC3486 (25 μM; 4 days, in combination with VDL chemotherapy) sensitizes pre-B-ALL LAX7R, ICN3, and SFO3 cells to Vincristine (HY-N0488A), Dexamethasone (HY-14648) and L-asparaginase (HY-P1923) chemotherapy, significantly reducing cell viability compared to chemotherapy alone[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Patient-derived pre-B-cell acute lymphoblastic leukemia (pre-B-ALL) LAX7R, ICN3, and SFO3 cells
-
Concentration:25 μM
-
Incubation Time:2 days
-
Result:Had no effect on the viability of LAX7R, ICN3, or SFO3 cells compared to control.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:NOD/SCID (xenotolerant)[1]
-
Dosage:10 mg/kg/day
-
Administration:i.p.; two injections per day; daily for 2 weeks
-
Result:Extended median survival time to 41 days compared to control MST of 33 days.
化学情報
-
CAS 番号 247044-77-5
-
分子量 557.68
-
分子式 C27H31N3O6S2
-
SMILES
[C@H](NC(N[C@H](C(N(CC1=CC=CS1)CC2=CC=CS2)=O)CCCC)=O)(CC(O)=O)C=3C=C4C(=CC3)OCO4
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TBC3486 関連分類
HY-122023 関連分類
Powered by Bioz