TZ3O
Based on 1 Customer Validation
TZ3O is an anticholinergic agent with neuroprotective effects. TZ3O inhibits acetylcholinesterase (AChE) activity in human plasma with an IC50 of 304.5 μM. TZ3O can improve memory impairment and cognitive decline in rats in the Scopolamine (HY-N0296)-induced Alzheimer-type model. TZ3O could be used in Alzheimer’s research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.17%
- 分子式: C18H13NO4S
- 分子量:339.37
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[1]|
AChE 304.5 μM (IC50) |
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Scopolamine (3 mg/kg, i.p.) was administered to adult male Wistar rats (250-300 g) to induce cholinergic neurotransmission disorder, constructing an Alzheimer’s disease model with memory and cognitive impairment[1]
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Dosage:0.5, 1, 2, 4 mg/kg
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Administration:i.p., 60 min before trials, 8 days total with 2 rest days
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Result:Reduced escape latency in Morris Water Maze test.
Increased spontaneous alternation behavior in Y-maze task.
Increased Nissl-stained neurons in hippocampal CA1/DG and cortex.
Upregulated mAChR M1 expression in hippocampal CA1/DG and cortex.
Reduced TUNEL-positive cells in hippocampus and cortex to inhibit neuron apoptosis.
Lowered AChE activity and relative expression in hippocampus and cortex.
Suppressed caspase 3 and caspase 8 activity in hippocampus and cortex.
Decreased plasma IL-6 and TNF-α levels.
Decreased hippocampal p-Tau and HSP70 levels.
Increased hippocampal BDNF, Nrf2 expression and hippocampal mAChR M1 protein expression.
Reduced plasma AST, ALT, and ALP levels.
化学情報
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性状 Solid
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分子量 339.37
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分子式 C18H13NO4S
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Color Light yellow to brown
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SMILES
O=C(S/C1=C/C2=CC=CC(O)=C2)N(C1=O)CC(C3=CC=CC=C3)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 125 mg/mL (368.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9466 mL | 14.7332 mL | 29.4664 mL | 73.6659 mL |
| 5 mM | 0.5893 mL | 2.9466 mL | 5.8933 mL | 14.7332 mL | |
| 10 mM | 0.2947 mL | 1.4733 mL | 2.9466 mL | 7.3666 mL | |
| 15 mM | 0.1964 mL | 0.9822 mL | 1.9644 mL | 4.9111 mL | |
| 20 mM | 0.1473 mL | 0.7367 mL | 1.4733 mL | 3.6833 mL | |
| 25 mM | 0.1179 mL | 0.5893 mL | 1.1787 mL | 2.9466 mL | |
| 30 mM | 0.0982 mL | 0.4911 mL | 0.9822 mL | 2.4555 mL | |
| 40 mM | 0.0737 mL | 0.3683 mL | 0.7367 mL | 1.8416 mL | |
| 50 mM | 0.0589 mL | 0.2947 mL | 0.5893 mL | 1.4733 mL | |
| 60 mM | 0.0491 mL | 0.2456 mL | 0.4911 mL | 1.2278 mL | |
| 80 mM | 0.0368 mL | 0.1842 mL | 0.3683 mL | 0.9208 mL | |
| 100 mM | 0.0295 mL | 0.1473 mL | 0.2947 mL | 0.7367 mL |
TZ3O 関連分類
HY-155822 関連分類
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