UNC0638 hydrate
Based on 12 publication(s) in Google Scholar
UNC0638 hydrate selectively inhibits G9a and GLP histone methyltransferases with IC50 of 15 nM and 19 nM, respectively. UNC0638 hydrate inhibits TNBC cell invasion and migration in vitro. UNC0638 hydrate is also an inhibitor of EHMT1/2 and induces fetal hemoglobin (HbF) expression in human erythroid progenitor cell culture. In addition, UNC0638 hydrate has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1255517-77-1
- 分子式: C30H49N5O3
- 分子量:527.74
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 UNC0638 hydrate
More- Cancer Res. 2026 Jun 10. [Abstract]
- Nat Commun. 2026 Feb 12;17(1):1214. [Abstract]
- Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]
- Acta Pharmacol Sin. 2025 Aug 19. [Abstract]
- Acta Pharmacol Sin. 2022 Feb;43(2):457-469. [Abstract]
- Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2961-2966. [Abstract]
- Cell Chem Biol. 2022 Jul 21;29(7):1153-1161.e5. [Abstract]
- Cell Biosci. 2023 Jan 12;13(1):7. [Abstract]
- Mol Med Rep. 2018 Feb;17(2):2239-2244. [Abstract]
- J Neurosci. 2025 Jan 17:e1790242024. [Abstract]
- Mol Carcinog. 2024 Nov;63(11):2119-2132. [Abstract]
- bioRxiv. 2023 Nov 17.
Customer Validation & Images
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WB
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Cell Proliferation/Viability Assay
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Cell Migration/Invasion Assay
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Cell Proliferation/Viability Assay
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RT-PCR
Histone Methyltransferase アイソフォーム固有の製品をすべて表示
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生物活性
IC50: <15 nM (G9a), 19±1 nM (GLP)[1]
化学情報
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CAS 番号 1255517-77-1
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分子量 527.74
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分子式 C30H49N5O3
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SMILES
CC(N1CCC(NC2=C3C=C(OC)C(OCCCN4CCCC4)=CC3=NC(C5CCCCC5)=N2)CC1)C.O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (12)
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Journal Impact Factor
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Most Recent
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Cancer Res
TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Anti-Tumor Immunity and Immunotherapy Efficacy. [Abstract]2026 Jun 10. PMID: 42268285 -
Nat Commun
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]2026 Feb 12;17(1):1214. PMID: 41680175 -
Cell Death Dis
Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway. [Abstract]2018 Jan 26;9(2):129. PMID: 29374157
UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]
The effects of treatment with UNC0638 (10 μM) on cleaved PARP (Clv-PARP) expression in both PC9/ER and HCC827/ER cells. β-actin is used as a loading control.
UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]
The EHMT2 inhibitor UNC0638 (5-10 μM; 48 h) effectively inhibited cell growth in both PC9/ER and HCC827/ER cells.
UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]
UNC0638 (100 nM; 48 h) suppressed cell migration in PC9 and PC9/ER cells.
UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]
UNC0638 (100 nM; 48 h) pretreatment enhanced the sensitivity of PC9/ER cells to Erlotinib compared to non-pretreated cells.
UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]
Treatment with UNC0638 (10 μM) resulted in the downregulation of Bcl-2 and VEGF in EGFR-TKI-resistant NSCLC cell lines.
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Acta Pharmacol Sin
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity. [Abstract]2025 Aug 19. PMID: 40830678 -
Acta Pharmacol Sin
2022 Feb;43(2):457-469. PMID: 33850273 -
Proc Natl Acad Sci U S A
2019 Feb 19;116(8):2961-2966. PMID: 30718431 -
Cell Chem Biol
Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells. [Abstract]2022 Jul 21;29(7):1153-1161.e5. PMID: 35728598 -
Cell Biosci
Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification. [Abstract]2023 Jan 12;13(1):7. PMID: 36631841 -
Mol Med Rep
UNC0638, a G9a inhibitor, suppresses epithelial‑mesenchymal transition‑mediated cellular migration and invasion in triple negative breast cancer. [Abstract]2018 Feb;17(2):2239-2244. PMID: 29207160
UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2018 Feb;17(2):2239-2244. [Abstract]
UNC0638 (0.5 and 1 µM; 24 h) suppressed triple negative breast cancer cell migration and invasion by regulating EMT-associated proteins. Western blots of EMT-associated proteins were performed.
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J Neurosci
Histone Methyltransferase G9a in Primary Sensory Neurons Promotes Inflammatory Pain and Transcription of Trpa1 and Trpv1 via Bivalent Histone Modifications. [Abstract]2025 Jan 17:e1790242024. PMID: 39824634 -
Mol Carcinog
A novel high-risk model identified by epithelial-mesenchymal transition predicts prognosis and radioresistance in rectal cancer. [Abstract]2024 Nov;63(11):2119-2132. PMID: 39056517 -
純度とドキュメンテーション
参考文献
[1]. Vedadi M, et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011 Jul 10;7(8):566-74. [Content Brief]
[2]. Fu L, et al. Effects of the Histone Methyltransferase Inhibitor UNC0638 on Histone H3K9 Dimethylation of Cultured Ovine Somatic Cells and Development of Resulting Early Cloned Embryos. Reprod Domest Anim. 2014 Apr;49(2):e21-5. [Content Brief]
[3]. Singh N, et al. Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells. J Interferon Cytokine Res. 2016 Jan;36(1):37-47. [Content Brief]
[4]. Liu X R, et al. UNC0638, a G9a inhibitor, suppresses epithelial‑mesenchymal transition‑mediated cellular migration and invasion in triple negative breast cancer[J]. Molecular medicine reports, 2018, 17(2): 2239-2244. [Content Brief]
[5]. Nualkaew T, et al. UNC0638 induces high levels of fetal hemoglobin expression in β-thalassemia/HbE erythroid progenitor cells[J]. Annals of hematology, 2020, 99: 2027-2036. [Content Brief]
Calculators
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UNC0638 hydrate 関連分類
HY-110093 関連分類
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