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SB225002

65 Cited Publications
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Based on 65 publication(s) in Google Scholar

SB225002, a potent, selective and non-peptide CXCR2 antagonist, inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM.

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  • Purity: 99.90%
  • CAS No.: 182498-32-4
  • 화학식: C13H10BrN3O4
  • 분자량:352.14
  • 보관:

    4°C, stored under nitrogen

    * In solvent : -80°C, 2 years; -20°C, 1 year (stored under nitrogen)

  • SB225002 Chemical Structure
    SB225002 Chemical Structure
  • Experimental Validation Results for SB225002
  • Experimental Validation Results for SB225002
  • Experimental Validation Results for SB225002
  • Experimental Validation Results for SB225002
  • Experimental Validation Results for SB225002
CAS No.: 182498-32-4
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In Vivo Efficacy StudyFlow CytometryIF
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  • SB225002 Chemical Structure
    SB225002 Chemical Structure
    1/16
  • 1/16

    SB225002 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Oct 14;15(1):8845. [Abstract]

    Customer Validation
     SB225002 was administered i.p. at 10 mg/kg after SBRT, and every day for 8 days. Kaplan–Meier survival curves of the efficacy experiment were generated.

  • 1/16

    SB225002 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Nov;10(33):e2302498. [Abstract]

    Customer Validation
     5 mg/kg SB225002 was administered twice a week alone or in combination by intraperitoneal injection according to the experimental objective. A schematic representation of the therapy schedule for AB680, anti-PD-1 antibody, and CXCR2 inhibitor SB225002 in the KPC orthotopic model was shown. The images of KPC orthotopic allografts from the Control, SB225002, anti-PD-1+AB680, and combination groups were shown.

  • 1/16

    SB225002 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Nov;10(33):e2302498. [Abstract]

    Customer Validation
     5 mg/kg SB225002 twice a week alone or in combination by intraperitoneal injection according to the experimental objective The percentages of total CD8+ T cells, Granzyme B+ cells among the total CD8+ T cells, and CXCR2+ MDSCs in the tumors of each group at the endpoint were determined by flow cytometry.

  • 1/16

    SB225002 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Nov 26;13(1):7281. [Abstract]

    Customer Validation
     SB225002 (2 mg/kg) in DMSO was diluted in corn oil for in vivo administration through intraperitoneal injection every other day or gavage daily, respectively. Mice were inoculated with WT or Arid1a KO Myc-CaP cells and treated with or without SB225002. Quantification of each tumor-infiltrating immune cell population. was measured by FACS analysis.

  • 1/16

    SB225002 purchased from MedChemExpress. Usage Cited in: J Autoimmun. 2018 May:89:30-40. [Abstract]

    Customer Validation
     The blockade of neutrophil infiltration and intracutaneous injection of exogenous galectin-3 ameliorates skin inflammation in galectin 3-/- mice

  • SB225002