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Cat. No.: HY-161661

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Anticancer agent 223

Anticancer agent 223 (Compound V-d) is an anticancer agent that triggers cell death through caspase-dependent and caspase-independent mechanisms. Anticancer agent 223 inhibits tumor spheroid formation and resensitizes cisplatin (HY-17394)-resistant A2780 cells to cisplatin (HY-17394) treatment.

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CAS No.: 1328150-75-9
화학식: C₂₀H₁₉ClN₄O
분자량:366.84

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Anticancer agent 223 Chemical Structure

CAS No.: 1328150-75-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
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Classifications
Bioz

Biological Activity

제품 설명

All Caspase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	5.68 μM Compound: V-d	Antiproliferative activity against human A2780 cells assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human A2780 cells assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 38754563]
HK-2	IC₅₀	>50 μM Compound: V-d	Cytotoxicity against HK-2 cells Cytotoxicity against HK-2 cells	[PMID: 38754563]

Chemical Information

CAS No. 1328150-75-9
분자량 366.84
화학식 C₂₀H₁₉ClN₄O
SMILES

ClC1=CC=C(NC(C2CCN(C3=NC=NC4=C3C=CC=C4)CC2)=O)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Thuy Lu Vo T, et al. Design, synthesis and biological evaluation of novel quinazoline derivatives as immune checkpoint inhibitors. Bioorg Med Chem Lett. Published online May 15, 2024. [Content Brief]

Calculators

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Mass Mass

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
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순도&문서
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Anticancer agent 223

All Caspase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Anticancer agent 223 Related Classifications

HY-161661 Related Classifications