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Cat. No.: HY-121197

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Balanol

(Synonyms: Ophiocordin; Azepinostatin)

Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC₅₀s=4-9 nM) and ζ (IC₅₀=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides.

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CAS No.: 63590-19-2
화학식: C₂₈H₂₆N₂O₁₀
분자량:550.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Balanol Chemical Structure

CAS No.: 63590-19-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[2]

Human PKCα

4-9 nM ()

PKC-βI

4-9 nM ()

PKC-βII

4-9 nM ()

Human PKCγ

4-9 nM ()

Human PKCδ

4-9 nM ()

Human PKCε

4-9 nM ()

human PKCη

150 nM ()

PKA

All PKA Isoforms :

All PKC Isoforms :

In Vitro

Balanol (3 μM; 45 min) inhibits PKA, as inhibiting the induction of luciferase activity by Isoproterenol (HY-B0468) in neonatal rat myocytes A431 cells^[1].
Balanol (10 μM; 45 min) inhibits the phosphorylation of CREB and MARCKS in A431 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 63590-19-2
분자량 550.51
화학식 C₂₈H₂₆N₂O₁₀
SMILES

O=C(C1=C(C=C(C(O[C@H]2[C@@H](CNCCC2)NC(C3=CC=C(O)C=C3)=O)=O)C=C1O)O)C4=C(C=CC=C4O)C(O)=O
Synonyms

Ophiocordin; Azepinostatin
Initial Source
- Microorganisms
V. balanoides
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gustafsson AB, et al. Differential and selective inhibition of protein kinase A and protein kinase C in intact cells by balanol congeners. Mol Pharmacol. 1999 Aug;56(2):377-82. [Content Brief]

[2]. Kulanthaivel P, et al. Balanol: a novel and potent inhibitor of protein kinase C from the fungus Verticillium balanoides. Journal of the American Chemical Society, 1993, 115(14): 6452-6453.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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Balanol

All PKA Isoforms

All PKC Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Balanol Related Classifications

HY-121197 Related Classifications