Cathelicidin-PY
Cathelicidin-PY is an antimicrobial peptide exhibiting strong antimicrobial property. Cathelicidin-PY inhibits the activation of TLR4 inflammatory response pathways induced by lipopolysaccharide (LPS) (HY-D1056). Cathelicidin-PY possesses strong antimicrobial and anti-inflammatory activities and low cytotoxic ability against RAW 264.7 cells. Cathelicidin-PY can be used for antimicrobial and anti-inflammatory research.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 1431866-92-0
- 화학식: C151H263N47O39S2
- 분자량:3425.13
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
제품 설명
In Vitro
Cathelicidin-PY exerts strong antimicrobial abilities against most of the tested microorganisms with MIC ranging from 4.69-37.5 μg/mL, and shows same antimicrobial activity against both clinically isolated drug-resistant and standard strains[1].
Cathelicidin-PY (2.5-20 μg/mL, 24 h) exerts anti-inflammatory activitiy by inhibiting the production of nitric oxide (NO) and inflammatory cytokines such as TNF-α, IL-6, and monocyte chemoattractant protein-1 (MCP-1)[1].
Cathelicidin-PY (5-20 μg/mL, 1 h) inhibits the LPS-induced TLR4 signaling pathway in RAW 264.7 murine macrophage cells by downregulating TLR4 expression, inhibiting JNK activation, and preventing NF-κB p65 nuclear translocation in a dose-dependent manner[1].
Cathelicidin-PY (1xMIC, 30 min) induces perturbation of the E. coli cell membrane, as evidenced by membrane breaks, outflow of cellular inclusions, and a vague cell boundary[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:RAW 264.7 murine macrophage cells
-
Concentration:0, 5, 10, and 20 μg/mL
-
Incubation Time:1 h
-
Result:Inhibited the expression of TLR4, JNK, and the translocation of NF-κB from cytoplasm to nucleus in a dose-dependent manner.
Inhibited 85% TLR4 expression and 74% NF-κB translocation induced by LPS (100 ng/mL, 3 h) at the concentration of 20 μg/mL, respectively.
Inhibited JNK expression induced by LPS.
Completely blocked LPS-induced JNK2 expression at 10 or 20 μg/mL.
Chemical Information
-
CAS No. 1431866-92-0
-
분자량 3425.13
-
화학식 C151H263N47O39S2
-
Sequence
Arg-Lys-Cys-Asn-Phe-Leu-Cys-Lys-Leu-Lys-Glu-Lys-Leu-Arg-Thr-Val-Ile-Thr-Ser-His-Ile-Asp-Lys-Val-Leu-Arg-Pro-Gln-Gly
-
Sequence Shortening
RKCNFLCKLKEKLRTVITSHIDKVLRPQG
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cathelicidin-PY Related Classifications
HY-P11183 Related Classifications
Powered by Bioz