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Cat. No.: HY-P11704

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f-MKKFRW

f-MKKFRW is a selective mouse formyl peptide receptor 3 (Fpr3) activator and bacterial MgrB-derived peptide motif. f-MKKFRW activates Fpr3 to trigger downstream signaling and calcium responses in Fpr3-expressing cells. f-MKKFRW stimulates a subset of mouse vomeronasal sensory neurons in the accessory olfactory system to evoke calcium responses. f-MKKFRW drives innate avoidance behavior in mice via nasal contact.

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화학식: C₄₄H₆₆N₁₂O₈S
분자량:923.14

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

f-MKKFRW Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

In Vivo

f-MKKFRW (50-100 μM; topical application to filter paper; single exposure) drives Fpr3-, Gao-, and Trpc2-dependent innate avoidance behavior in naive male mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6N (B6) mice (male, 8-14 weeks old); ΔFpr3-lacZ +/+ mice; cGao +/- mice; Trpc2 +/- mice^[1]
Dosage:

50 μM; 100 μM
Administration:

topical application to filter paper; single exposure
Result:

Induced a mean avoidance index of -0.34 in B6 mice, indicating significant avoidance of the peptide-supplemented FEU compared to plain FEU. Showed absent avoidance in ΔFpr3-lacZ -/-, cGao -/-, and Trpc2 -/- mice.
Triggered avoidance behavior at the 50 μM dose.

Chemical Information

분자량 923.14
화학식 C₄₄H₆₆N₁₂O₈S
Sequence

{fMet}-Lys-Lys-Phe-Arg-Trp
Sequence Shortening

{fMet}-MKKFRW
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bufe B, et al. Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour. Nat Commun. 2019;10(1):4889. Published 2019 Oct 25. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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