Grossamide
Based on 1 publication(s) in Google Scholar
Grossamide is a natural product that can be isolated from fructus cannabis, the dried fruit of Cannabis sativa L.. Grossamide has anti-neuroinflammatory effects.
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- Purity: 98.0%
- CAS No.: 80510-06-1
- 화학식: C36H36N2O8
- 분자량:624.68
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보관:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Grossamide
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Biological Activity
Grossamide downregulates LPS-mediated production of inflammatory molecules[1].
Grossamide (0-20 μM, 1 h) inhibits the mRNA levels of TNF-α and IL-6 in a dose-dependent manner, inhibits LPS-induced NF-κB activation, and inhibits LPS-induced TLR4 and MyD88 expression without cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BV-2 microglia cell
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Concentration:0, 10, 15, and 20 μM
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Incubation Time:1 h and co-cultured with LPS (100 ng/mL) for another 6 h
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Result:Inhibited the mRNA levels of TNF-α and IL-6 in a dose-dependent manner.
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Cell Line:BV-2 microglia cell
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Concentration:0, 10, 15, and 20 μM
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Incubation Time:1 h followed by LPS (100 ng/mL) stimulation for 1 h or 24 h
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Result:Inhibited LPS-induced phosphorylation of IκBα and significantly reduced phosphorylation of NF-κB p65 levels. Dose-dependently decreased the expression of TLR4 and MyD88.
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Cell Line:BV-2 microglia cell
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Concentration:0, 10, 15, and 20 μM
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Incubation Time:1 h and co-cultured in the absence or presence of 100 ng/ mL LPS for 24 h
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Result:Had no cytotoxicity.
Chemical Information
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CAS No. 80510-06-1
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Appearance Solid
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분자량 624.68
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화학식 C36H36N2O8
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Color White to off-white
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SMILES
O=C([C@H]1C2=CC(/C=C/C(NCCC(C=C3)=CC=C3O)=O)=CC(OC)=C2O[C@]1([H])C(C=C4)=CC(OC)=C4O)NCCC(C=C5)=CC=C5O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Comput Aided Mol Des
Integrated computational and experimental evaluation of grossamide as a natural product scaffold for dual carbohydrase inhibition in diabetes. [Abstract]2025 Nov 10;39(2):122. PMID: 41212441
순도&문서
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Grossamide Related Classifications
HY-N3979 Related Classifications
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