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Cat. No.: HY-156615

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Igermetostat

Name: Igermetostat
Brand: MedChemExpress
SKU: HY-156615
Price: 960.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: XNW5004)

Igermetostat (XNW5004) is an orally active EZH2 inhibitor for research related to metastatic castration-resistant prostate cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2409538-60-7
화학식: C₃₂H₄₆N₄O₄
분자량:550.73

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

Igermetostat Chemical Structure

CAS No.: 2409538-60-7

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Igermetostat (XNW5004) is an orally active EZH2 inhibitor for research related to metastatic castration-resistant prostate cancer^[1]^[2].

IC₅₀ & Target

^[1]

EZH2

All Histone Methyltransferase Isoforms :

In Vivo

Anti-cancer

Igermetostat (XNW5004) (800‑1600 mg; twice daily; oral, in combination with Enzalutamide (HY-70002) 160 mg once daily) exhibits antitumor efficacy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2409538-60-7
분자량 550.73
화학식 C₃₂H₄₆N₄O₄
SMILES

O=C(NCC1=C(C)C=C(C)NC1=O)C2=CC(O[C@H]3C[C@H](N4CCCCC4)C3)=CC(N(CC)C5CCOCC5)=C2C
Synonyms

XNW5004
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chang Y, et al. A phase 1b/2 study to evaluate the safety and efficacy of igermetostat (XNW5004) in combination with enzalutamide in patients with metastatic castration‑resistant prostate cancer. Journal of Clinical Oncology. 2026;44(7_suppl):169.

[2]. Louati K, et al. The Identification by Shotgun Proteomics with High-Resolution Tandem Mass-Spectrometry of Histone Isoforms' Hypermethylation Phenotype as a Hallmark Characteristic of Human-IDH-Mutant High-Grade Gliomas: Epigenetic Applications for Genotoxicity-Based Biomarkers and Cancer Therapy Targets. Journal of proteome research. 2025 Sep 05;24(9):4503-4525.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Igermetostat

All Histone Methyltransferase Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vivo

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Igermetostat Related Classifications

HY-156615 Related Classifications

Bioz

Keywords

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