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Cat. No.: HY-129599

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L-2286

L-2286 is an orally active PARP-1 inhibitor. L-2286 alleviates carotid artery remodeling, oxidative stress and inflammation in spontaneously hypertensive rats, protects neurons in the dorsal hippocampus, and reduces pyramidal cell loss and gliosis without affecting blood pressure. L-2286 can be used in research related to hypertension.

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CAS No.: 684276-17-3
화학식: C₁₅H₁₉N₃OS
분자량:289.40

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

L-2286 Chemical Structure

CAS No.: 684276-17-3

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

PARP-1

All PARP Isoforms :

All NF-κB Isoforms :

In Vivo

L-2286 (5 mg/kg, administered via drinking water for 32 weeks) alleviates carotid vascular remodeling and oxidative damage in the dorsal hippocampus of spontaneously hypertensive rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Spontaneously Hypertensive Rats (SHR) (10-week-old male, hypertension model)^[1]
Dosage:

5 mg/kg/day
Administration:

administered via drinking water for 32 weeks
Result:

Significantly reduced carotid intima‑media thickening, interstitial fibrosis, oxidative/nitrosative stress, nuclear factor‑κB (NF‑κB) nuclear translocation, and apoptosis‑inducing factor (AIF)‑dependent cell death in carotid arteries, while improving endothelium‑dependent vasodilation in spontaneously hypertensive rats.
Mitigated oxidative damage, pyramidal neuron loss, DNA oxidation, poly(ADP‑ribose) polymerase (PAR) formation, reactive astrogliosis, and perivascular white matter lesions in the dorsal hippocampus, all without altering systolic blood pressure.

Chemical Information

CAS No. 684276-17-3
분자량 289.40
화학식 C₁₅H₁₉N₃OS
SMILES

O=C1NC(SCCN2CCCCC2)=NC3=C1C=CC=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Eros K, et al. Chronic PARP-1 inhibition reduces carotid vessel remodeling and oxidative damage of the dorsal hippocampus in spontaneously hypertensive rats. PLoS One. 2017;12(3):e0174401. Published 2017 Mar 24. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
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L-2286

All PARP Isoforms

All NF-κB Isoforms