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Cat. No.: HY-136959

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M133

M133 is a HDAC1 and HDAC2 selective inhibitor which shows potent antiproliferative activity against diverse human tumor cell lines with IC₅₀s of 0.75-1.94 μM. M133 can be used for cancer research.

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CAS No.: 2127411-61-2
화학식: C₂₃H₂₄N₄OS₂
분자량:436.59

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

M133 Chemical Structure

CAS No.: 2127411-61-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	1.94 μM Compound: M133	Antiproliferative activity against human A375 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human A375 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
HCT-116	IC₅₀	0.75 μM Compound: M133	Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HCT116 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
HeLa	IC₅₀	1.04 μM Compound: M133	Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
MGC-803	IC₅₀	1.37 μM Compound: M133	Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human MGC803 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
NCI-H1299	IC₅₀	0.75 μM Compound: M133	Antiproliferative activity against human NCI-H1299 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human NCI-H1299 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]
SMMC-7721	IC₅₀	1.21 μM Compound: M133	Antiproliferative activity against human SMMC7721 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human SMMC7721 cells after 72 hrs by CCK-8 assay	[PMID: 29202397]

Chemical Information

CAS No. 2127411-61-2
분자량 436.59
화학식 C₂₃H₂₄N₄OS₂
SMILES

O=C(C1=CC=C(CSC(N(CC)CC2=CC=NC=C2)=S)C=C1)NC3=C(N)C=CC=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xie R, et al. Design, synthesis and biological evaluation of novel 2-aminobenzamides containing dithiocarbamate moiety as histone deacetylase inhibitors and potent antitumor agents. Eur J Med Chem. 2018 Jan 1;143:320-333. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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M133

All HDAC Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

M133 Related Classifications

HY-136959 Related Classifications