ML399
ML399 is a Menin-MLL1 protein-protein interaction inhibitor with an IC50 of 90 nM. ML399 inhibits the proliferation of transformed mouse bone marrow cells. ML399 binds to the hERG potassium channel, exhibits superior in vitro physicochemical, drug metabolism and pharmacokinetic (DMPK) parameters, and has an extended half-life in rodents. ML399 can be used for research on acute myeloid leukemia and acute lymphoblastic leukemia.
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- CAS No.: 1560968-49-1
- 화학식: C27H28FN3O2
- 분자량:445.53
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
ML399 (72 h) inhibits proliferation of MLL-AF9-transformed murine bone marrow cells with a GI50 of 4 μM[1].
ML399 exhibits improved in vitro DMPK properties, with human microsomal intrinsic clearance of 20 mL/min/kg, predicted human hepatic clearance of 10 mL/min/kg, and plasma protein binding fraction unbound values of 0.062 (human), 0.074 (rat), and 0.079 (mouse)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | CLplasma | T1/2 | Vss |
|---|---|---|---|---|---|
| Rat[1] | 0.2 mg/kg | i.v. | 12 mL/min/kg | 10.1 h | 7.4 L/kg |
Chemical Information
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CAS No. 1560968-49-1
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Appearance Solid
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분자량 445.53
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화학식 C27H28FN3O2
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Color White to off-white
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SMILES
O[C@@](C1CCN(CC1)CCCOC2=CC=C(C=C2)C#N)(C3=CC=CC=N3)C4=CC(F)=CC=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ML399 Related Classifications
HY-117948 Related Classifications
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- ML399
- 1560968-49-1
- ML 399
- ML-399
- Epigenetic Reader Domain
- Potassium Channel
- human microsomes
- rats
- menin-MLL protein-protein interaction
- acute myeloid leukemia
- menin-MLL1 protein-protein interaction
- MLL-AF9-transformed murine bone marrow cells
- murine bone marrow cells
- acute lymphoblastic leukemia
- mice
- hERG potassium ion channel
- Inhibitor
- inhibitor
- inhibit