Olvanil
Based on 1 Customer Validation
Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM.
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- Purity: 98.0%
- CAS No.: 58493-49-5
- 화학식: C26H43NO3
- 분자량:417.62
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보관:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
TRPV1 0.7 nM (EC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
202 nM
Compound: 24
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Agonist activity at rat TRPV1 expressed in CHO cells assessed as calcium uptake
Agonist activity at rat TRPV1 expressed in CHO cells assessed as calcium uptake
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[PMID: 22796184] |
| DMS-114 | IC50 |
>50 μM
Compound: 5
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Antiproliferative activity in human DMS-114 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human DMS-114 cells assessed as cell growth inhibition by MTT assay
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[PMID: 33508189] |
| EFM-19 | IC50 |
0.7 μM
Compound: 5
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Antiproliferative activity in human EFM-19 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human EFM-19 cells assessed as cell growth inhibition by MTT assay
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[PMID: 33508189] |
| MCF7 | IC50 |
1 μM
Compound: 5
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Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human MCF7 cells assessed as cell growth inhibition by MTT assay
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[PMID: 33508189] |
| T47D | IC50 |
0.75 μM
Compound: 5
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Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay
Antiproliferative activity in human T47D cells assessed as cell growth inhibition by MTT assay
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[PMID: 33508189] |
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats weighing approximately 200 g[3]
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Dosage:0, 0.2, 1.0 and 5.0 mg/kg
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Administration:Injected intraperitoneally 30 min before the behavioral tests
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Result:The percent open arm times at 5 min were 12.9±8.1 for the 0 mg/kg dose, 8.9±4.2 for the 0.2 mg/kg dose, 15.2±7.9 for the 1 mg/kg dose and 0±0 for the 5 mg/kg dose.
The mean number of entries into the closed arm at 5 min were 1.7±0.3, 3.3±0.8, 2.7±0.3 and 0.25±0.1 for doses of 0, 0.2, 1 and 5 mg/kg, respectively.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 58493-49-5
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Appearance Solid
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분자량 417.62
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화학식 C26H43NO3
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Color White to off-white
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SMILES
CCCCCCCC/C=C\CCCCCCCC(NCC1=CC=C(O)C(OC)=C1)=O
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Synonyms
NE-19550; N-Vanillyloleamide
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
용액&용해도
In Vitro:
DMSO : 100 mg/mL (239.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Giovanni Appendino, et al. Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential. J Pharmacol Exp Ther. 2005 Feb;312(2):561-70. [Content Brief]
[2]. S O Jacobsson, et al. Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors.J Pharmacol Exp Ther. 2001 Dec;299(3):951-9. [Content Brief]
[3]. John W Kasckow, et al. Effects of the vanilloid agonist olvanil and antagonist capsazepine on rat behaviors. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Mar;28(2):291-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3945 mL | 11.9726 mL | 23.9452 mL | 59.8630 mL |
| 5 mM | 0.4789 mL | 2.3945 mL | 4.7890 mL | 11.9726 mL | |
| 10 mM | 0.2395 mL | 1.1973 mL | 2.3945 mL | 5.9863 mL | |
| 15 mM | 0.1596 mL | 0.7982 mL | 1.5963 mL | 3.9909 mL | |
| 20 mM | 0.1197 mL | 0.5986 mL | 1.1973 mL | 2.9932 mL | |
| 25 mM | 0.0958 mL | 0.4789 mL | 0.9578 mL | 2.3945 mL | |
| 30 mM | 0.0798 mL | 0.3991 mL | 0.7982 mL | 1.9954 mL | |
| 40 mM | 0.0599 mL | 0.2993 mL | 0.5986 mL | 1.4966 mL | |
| 50 mM | 0.0479 mL | 0.2395 mL | 0.4789 mL | 1.1973 mL | |
| 60 mM | 0.0399 mL | 0.1995 mL | 0.3991 mL | 0.9977 mL | |
| 80 mM | 0.0299 mL | 0.1497 mL | 0.2993 mL | 0.7483 mL | |
| 100 mM | 0.0239 mL | 0.1197 mL | 0.2395 mL | 0.5986 mL |
Olvanil Related Classifications
HY-101323 Related Classifications
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