Cat. No.: HY-145696

SJ10542

고객리뷰

Based on 1 Customer Validation

SJ10542 is a potent and selective JAK2/3 PROTAC degrader. In PDX cells lSJBALL020589, SJ10542 has DC₅₀ values of 14 and 11 nM for JAK2 and JAK3, respectively. SJ10542 exhibits antitumor activity and can be used for the research of hematological malignancies and autoimmune diseases.
(Pink: JAK2 and JAK3 Target protein ligand; Blue: Cereblon ligand (HY-W890189); Black: linker).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.32%
CAS No.: 2789678-92-6
화학식: C₄₁H₄₆N₁₂O₅S
분자량:818.95

보관:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

SJ10542 Chemical Structure

CAS No.: 2789678-92-6

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

SJ10542 is a potent and selective JAK2/3 PROTAC degrader. In PDX cells lSJBALL020589, SJ10542 has DC₅₀ values of 14 and 11 nM for JAK2 and JAK3, respectively. SJ10542 exhibits antitumor activity and can be used for the research of hematological malignancies and autoimmune diseases^[1]. (Pink: JAK2 and JAK3 Target protein ligand; Blue: Cereblon ligand (HY-W890189); Black: linker).

IC₅₀ & Target^[1]

JAK2

14 nM (DC₅₀)

JAK3

11 nM (DC₅₀)

JAK2-fusion ALL

24 nM (DC₅₀)

Cereblon

All PROTACs Isoforms :

All JAK Isoforms :

In Vitro

SJ10542 (1-9000 nM; 24 h) potently degrades JAK2 (DC₅₀: 24 nM), JAK3 and GSPT1 in MHH-CALL-4 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MHH-CALL-4 cells
Concentration:

1, 10, 100, 1000 and 9000 nM
Incubation Time:

24 h
Result:

Inhibited the levels of JAK2, JAK3 and GSPT1 in a dose-dependent manner.

Chemical Information

CAS No. 2789678-92-6
Appearance Solid
분자량 818.95
화학식 C₄₁H₄₆N₁₂O₅S
Color White to off-white
SMILES

O=C(C1=CC=C(NC2=NC(NC=C3)=C3C(C4=CN(C5(CN(S(=O)(CC)=O)C5)CC#N)N=C4)=N2)C=C1)NCCCN(CC6)CCN6C7=CC=C(C=C7)C8C(NC(CC8)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 46.67 mg/mL (56.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.2211 mL

6.1054 mL

12.2108 mL

5 mM

0.2442 mL

1.2211 mL

2.4422 mL

10 mM

0.1221 mL

0.6105 mL

1.2211 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: 2.5 mg/mL (3.05 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lisa J.Alcock,et al. Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs.ACS Med.Chem.Lett.2022,13,3,475-482.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.2211 mL	6.1054 mL	12.2108 mL	30.5269 mL
	5 mM	0.2442 mL	1.2211 mL	2.4422 mL	6.1054 mL
	10 mM	0.1221 mL	0.6105 mL	1.2211 mL	3.0527 mL
	15 mM	0.0814 mL	0.4070 mL	0.8141 mL	2.0351 mL
	20 mM	0.0611 mL	0.3053 mL	0.6105 mL	1.5263 mL
	25 mM	0.0488 mL	0.2442 mL	0.4884 mL	1.2211 mL
	30 mM	0.0407 mL	0.2035 mL	0.4070 mL	1.0176 mL
	40 mM	0.0305 mL	0.1526 mL	0.3053 mL	0.7632 mL
	50 mM	0.0244 mL	0.1221 mL	0.2442 mL	0.6105 mL

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SJ10542

PROTAC Library

MCE Bioactive Compound Library

All PROTACs Isoforms

All JAK Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

SJ10542

PROTAC Library

MCE Bioactive Compound Library

All PROTACs Isoforms

All JAK Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

SJ10542 Related Classifications

HY-145696 Related Classifications