SJL2-1
SJL2-1 is a PRMT5 inhibitor, with an IC50 of 1.56 μM. SJL2-1 suppresses proliferation, migration, and invasion in prostate cancer cells. SJL2-1 promotes apoptosis and blocks the cell cycle at the G0/G1 phase. SJL2-1 can target the binding of PRMT5 in cells and inhibit the methylation and expression of the androgen receptor. SJL2-1 can be used for the study of early androgen-sensitive prostate cancer and advanced castration-resistant prostate cancer (CRPC).
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- 화학식: C22H26N2O
- 분자량:334.45
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
SJL2-1 (2.96-60 μM, 24-96 h) suppresses proliferation, migration, and invasion in prostate cancer cells including 22RV1, PC-3, and LNCaP cells[1].
SJL2-1 (15-45 μM, 48 h) promotes apoptosis and blocks the cell cycle at the G0/G1 phase in prostate cancer cells including 22RV1, PC-3, and LNCaP cells[1].
SJL2-1 (15-45 μM) inhibits PRMT5 expression, reduces downstream SDMA levels and SmD3me2S protein expression, and decreases the androgen receptor expression in 22RV1, PC-3, and LNCaP cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3, 22RV1, and LNCaP cells
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Concentration:1-60 μM
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Incubation Time:24, 48, 72, 96 h
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Result:Showed the anti-proliferation in PC-3 cells with IC50s of 46.11 μM (24 h), 37.29 μM (48 h), 32.74 μM (72 h) and 26.24 μM (96 h).
Showed the anti-proliferation in 22RV1 cells with IC50s of 44.31 μM (24 h), 40.07 μM (48 h), 33.41 μM (72 h) and 26.09 μM (96 h).
Showed the anti-proliferation in LNCAP cells with IC50s of 5.92 μM (24 h), 4.29 μM (48 h), 4.68 μM (72 h) and 4.45 μM (96 h).
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Cell Line:PC3, 22RV1, and LNCaP cells
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Concentration:23.055 μM (PC3 cells), 22.155 μM (22RV1 cells), 2.96 μM (LNCAP cells)
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Incubation Time:24 h
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Result:Inhibited cell proliferation and reduced active DNA replication in 5-Ethynyl-2’-Deoxyuridine(EdU) (HY-118411) incorporation assay.
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Cell Line:PC3, 22RV1, and LNCaP cells
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Concentration:23.055 μM (PC3 cells), 22.155 μM (22RV1 cells), 2.96 μM (LNCAP cells)
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Incubation Time:48 h
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Result:Reduced the number of migratory cells in PC-3, 22RV1, and LNCaP cells.
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Cell Line:PC3, 22RV1, and LNCaP cells
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Concentration:23.055 μM (PC3 cells), 22.155 μM (22RV1 cells), 2.96 μM (LNCAP cells)
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Incubation Time:48 h
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Result:Suppressed cell invasion ability in PC3, 22RV1, and LNCaP cells.
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Cell Line:PC-3, 22RV1, and LNCaP cells
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Concentration:15, 30, 45 μM
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Incubation Time:48 h
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Result:Impeded the progression of 22RV1, PC3, and LNCAP cells to the G1 phase in a dose-dependent manner, with a significant accumulation of cells in the G0/G1 phase and a concomitant decrease in the number of cells in the G2 phase.
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Cell Line:PC3, 22RV1, and LNCaP cells
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Concentration:15, 30 , 45 μM
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Incubation Time:48 h
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Result:Upregulated the pro-apoptotic effector Bax and elevated levels of both caspase-3 concentration-dependently.
Chemical Information
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분자량 334.45
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화학식 C22H26N2O
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SMILES
CC1=CN(CC(CN2C(C)C(C=CC=C3)=C3CC2)O)C4=CC=CC=C41
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SJL2-1 Related Classifications
HY-174908 Related Classifications
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