TZ3O
Based on 1 Customer Validation
TZ3O is an anticholinergic agent with neuroprotective effects. TZ3O inhibits acetylcholinesterase (AChE) activity in human plasma with an IC50 of 304.5 μM. TZ3O can improve memory impairment and cognitive decline in rats in the Scopolamine (HY-N0296)-induced Alzheimer-type model. TZ3O could be used in Alzheimer’s research.
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- Purity: 98.17%
- 화학식: C18H13NO4S
- 분자량:339.37
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
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AChE 304.5 μM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Scopolamine (3 mg/kg, i.p.) was administered to adult male Wistar rats (250-300 g) to induce cholinergic neurotransmission disorder, constructing an Alzheimer’s disease model with memory and cognitive impairment[1]
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Dosage:0.5, 1, 2, 4 mg/kg
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Administration:i.p., 60 min before trials, 8 days total with 2 rest days
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Result:Reduced escape latency in Morris Water Maze test.
Increased spontaneous alternation behavior in Y-maze task.
Increased Nissl-stained neurons in hippocampal CA1/DG and cortex.
Upregulated mAChR M1 expression in hippocampal CA1/DG and cortex.
Reduced TUNEL-positive cells in hippocampus and cortex to inhibit neuron apoptosis.
Lowered AChE activity and relative expression in hippocampus and cortex.
Suppressed caspase 3 and caspase 8 activity in hippocampus and cortex.
Decreased plasma IL-6 and TNF-α levels.
Decreased hippocampal p-Tau and HSP70 levels.
Increased hippocampal BDNF, Nrf2 expression and hippocampal mAChR M1 protein expression.
Reduced plasma AST, ALT, and ALP levels.
Chemical Information
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Appearance Solid
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분자량 339.37
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화학식 C18H13NO4S
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Color Light yellow to brown
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SMILES
O=C(S/C1=C/C2=CC=CC(O)=C2)N(C1=O)CC(C3=CC=CC=C3)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 125 mg/mL (368.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9466 mL | 14.7332 mL | 29.4664 mL | 73.6659 mL |
| 5 mM | 0.5893 mL | 2.9466 mL | 5.8933 mL | 14.7332 mL | |
| 10 mM | 0.2947 mL | 1.4733 mL | 2.9466 mL | 7.3666 mL | |
| 15 mM | 0.1964 mL | 0.9822 mL | 1.9644 mL | 4.9111 mL | |
| 20 mM | 0.1473 mL | 0.7367 mL | 1.4733 mL | 3.6833 mL | |
| 25 mM | 0.1179 mL | 0.5893 mL | 1.1787 mL | 2.9466 mL | |
| 30 mM | 0.0982 mL | 0.4911 mL | 0.9822 mL | 2.4555 mL | |
| 40 mM | 0.0737 mL | 0.3683 mL | 0.7367 mL | 1.8416 mL | |
| 50 mM | 0.0589 mL | 0.2947 mL | 0.5893 mL | 1.4733 mL | |
| 60 mM | 0.0491 mL | 0.2456 mL | 0.4911 mL | 1.2278 mL | |
| 80 mM | 0.0368 mL | 0.1842 mL | 0.3683 mL | 0.9208 mL | |
| 100 mM | 0.0295 mL | 0.1473 mL | 0.2947 mL | 0.7367 mL |
TZ3O Related Classifications
HY-155822 Related Classifications
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