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Cat. No.: HY-139796

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ZYJ-34v

ZYJ-34v is an orally active histone deacetylase inhibitor. ZYJ-34v has antitumor activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1450662-32-4
화학식: C₂₇H₃₅N₃O₆
분자량:497.58

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

ZYJ-34v Chemical Structure

CAS No.: 1450662-32-4

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

ZYJ-34v is an orally active histone deacetylase inhibitor. ZYJ-34v has antitumor activity^[1].

All HDAC Isoforms :

In Vitro

ZYJ-34v can inhibit HDACs. The IC₅₀ values of MDA-MB-231, HCT116, PC-3, HepG2 and MCF-7 cells were 1.41, 0.63 and 2.62, respectively. 4.23 and 4.76 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MDA-MB-231
Concentration:

1 μM
Incubation Time:

24 h
Result:

Inhibited deacetylation of tubulin, histone H3 and H4, and significantly induced an increase in the protein level of p21.

In Vivo

ZYJ-34v (90 mg/kg, orally, for 22 days) shows antitumor activity in MDA-MB-231 xenograft tumor model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

a mouse MDA-MB-231 xenograft model^[1]
Dosage:

90 mg/kg
Administration:

p.o.
Result:

Decreased the final tumor volume.

Related Protocols :

Subcutaneous Cell-Line-Derived Xenograft

Chemical Information

CAS No. 1450662-32-4
분자량 497.58
화학식 C₂₇H₃₅N₃O₆
SMILES

COC(C=C1)=CC=C1NC([C@H]2N(CC3=CC(OCC(NO)=O)=CC=C3C2)C(C(CCC)CCC)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity. Chem Biol Drug Des. 2013 Aug;82(2):125-30. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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