2. PROTAC Epigenetics
  3. PROTACs Histone Methyltransferase
  4. PROTAC EZH2 Degrader-25

PROTAC EZH2 Degrader-25 (compound 10) is an EZH2-targeting PROTAC degrader. PROTAC EZH2 Degrader-25 triggers ubiquitination and subsequent proteasomal degradation of EZH2. PROTAC EZH2 Degrader-25 can be used for the research of lymphoma.
(Pink: EZH2 ligand (HY-147230); Blue: Cereblon ligand (HY-103596); Black: linker).

For research use only. We do not sell to patients.

PROTAC EZH2 Degrader-25

PROTAC EZH2 Degrader-25 Chemical Structure

CAS No. : 2653338-69-1

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PROTAC EZH2 Degrader-25 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

PROTAC EZH2 Degrader-25 (compound 10) is an EZH2-targeting PROTAC degrader. PROTAC EZH2 Degrader-25 triggers ubiquitination and subsequent proteasomal degradation of EZH2. PROTAC EZH2 Degrader-25 can be used for the research of lymphoma[1]. (Pink: EZH2 ligand (HY-147230); Blue: Cereblon ligand (HY-103596); Black: linker).

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC EZH2 Degrader-25 Related Antibodies
Molecular Weight

900.07

Formula

C51H61N7O8
CAS No.
SMILES

CC1=C(C=C(C=C1N(CC)C2CCOCC2)C3=CC=C(C=C3)CN4CCN(CC4)CCCCOC5=C(C6=CC=C5)C(N(C6=O)C7CCC(NC7=O)=O)=O)C(NCC8=C(C=C(NC8=O)C)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC EZH2 Degrader-25 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC EZH2 Degrader-252653338-69-1PROTACsHistone MethyltransferaseEZH2lymphomalymphoma cellsVHL E3 ubiquitin ligaseproteasomal degradationubiquitinationInhibitorinhibitorinhibit

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