PROTAC EZH2 Degrader-34
PROTAC EZH2 Degrader-34 (compound E7 (13)) is an EZH2-target PROTAC degrader with a human EZH2 IC50 of 6.30 μM. PROTAC EZH2 Degrader-34 can be used for the research of pfeiffer cancer, prostate cancer.
(Pink: EZH2 ligand (HY-147230); Blue: Cereblon ligand (HY-103596); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2653338-71-5
- Formula: C55H69N7O8
- Molecular Weight:956.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PROTAC EZH2 Degrader-34 (compound E7 (13)) (10.00-30.00 μM) potently inhibits EZH2 enzymatic activity with an IC50 of 6.30 μM, induces CRBN-mediated proteasomal degradation of PRC2 subunits and reduces H3K27me2/3 levels in WSU-DLCL-2 cells, and exhibits strong antiproliferative activity in Pfeiffer (3.69 μM) and prostate (0.21 μM) cancer cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2653338-71-5
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Molecular Weight 956.18
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Formula C55H69N7O8
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SMILES
O=C(C1=CC(C2=CC=C(CN3CCN(CCCCCCCCOC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)CC3)C=C2)=CC(N(C7CCOCC7)CC)=C1C)NCC8=C(C)C=C(C)NC8=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC EZH2 Degrader-34 Related Classifications
HY-181391 Related Classifications
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