768 Results for "

Biological activity

" in MedChemExpress (MCE) Product Catalog:
Products (768)

768 Results for "Biological activity" in MCE Product Catalog:

14
14 Cited Publications
Cat. No.: HY-14616
CAS No.: 555-66-8
Purity:  99.63%
Synonyms: [6]-Shogaol; 6-Shogaol
Shogaol ([6]-Shogaol), an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
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12
12 Cited Publications
Cat. No.: HY-N0328
CAS No.: 6147-11-1
Synonyms: α-Mangostin
alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
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12
12 Cited Publications
Cat. No.: HY-N1372A
CAS No.: 436-77-1
Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing . Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK . Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer .
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11
11 Cited Publications
Cat. No.: HY-N0664
CAS No.: 479-98-1
Aucubin is an iridoid glycoside component that acn be found in E. ulmoides. Aucubin can cross the blood-brain barrier (BBB) and has anti-anxiety, antidepressive and anti-neuroinflammatory effects. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .
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10
10 Cited Publications
Cat. No.: HY-116282C
CAS No.: 9011-18-1
Synonyms: DSS (MW 35000-45000); DXS (MW 35000-45000)
Target:  

Apoptosis

Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a polymer of dehydrated glucose with a molecular weight of approximately 35000-45000. DSS with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a potent inducer of colitis. Dextran sulfate sodium salt (DSS) (MW 35000-45000) can be used to induce model acute colitis, chronic colitis, and colitis-related colon cancer. Dextran sulfate sodium salt (DSS) (MW 35000-45000) may be related to macrophage dysfunction, intestinal flora dysbiosis, and is particularly toxic to the colonic epithelium .
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9
9 Cited Publications
Cat. No.: HY-132179
CAS No.: 9072-19-9
Purity:  ≥98.0%
Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities .
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9
9 Cited Publications
Cat. No.: HY-N6653
CAS No.: 37339-90-5
Lentinan is an orally active biocompatible multifunctional polysaccharide with biological activities such as anti-inflammatory, antioxidant, immune regulation, anti-tumor, hypoglycemic, and lipid-lowering [1][4].
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9
9 Cited Publications
Cat. No.: HY-15681
CAS No.: 1366002-50-7
Purity:  99.79%
Target:  

CDK

Research Areas:  

Cancer

Senexin A is an inhibitor of CDK8/19 (IC50: 280 nM, CDK8) and an inhibitor downstream of p21 transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-κB-dependent promoters .
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8
8 Cited Publications
Cat. No.: HY-115364
CAS No.: 14255-87-9
Purity:  99.87%
Synonyms: SKF 29044
Parbendazole (SKF‑29044) is an orally active benzimidazole carbamate compound with multiple biological activities. Parbendazole binds to free tubulin and inhibits microtubule polymerization; it also activates the JNK/c‑Jun signaling axis and upregulates the expression of the downstream axonal repulsion factor Sema3A. Parbendazole upregulates KAL-1 mRNA expression, reduces nerve growth factor levels, and promotes the terminal differentiation of normal human epidermal keratinocytes. Parbendazole induces apoptosis in differentiated acute myeloid leukemia monocytes and exerts antileukemic activity in a mouse xenograft model of acute myeloid leukemia. Parbendazole exhibits broad-spectrum anthelmintic activity against various animal nematodes. Parbendazole is used in research related to acute myeloid leukemia and parasitic infections .
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7
7 Cited Publications
Cat. No.: HY-N1950
CAS No.: 1447-88-7
Synonyms: Dinatin
Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.
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7
7 Cited Publications
Cat. No.: HY-D0143
CAS No.: 130-95-0
Quinine is an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
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7
7 Cited Publications
Cat. No.: HY-D0143B
CAS No.: 207671-44-1
Quinine hemisulfate hydrate is an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine hemisulfate hydrate acts as a potassium channel inhibitor that suppresses the +100 mV current of MT mSlo3 (KCa5.1) channels induced by voltage pulses, with an IC50 value of 169 μM. Quinine hemisulfate hydrate serves as a fluorescence standard reference substance with fluorescence spectrum calibration and validation activity .
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7
7 Cited Publications
Cat. No.: HY-D0143A
CAS No.: 60-93-5
Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark, possessing various biological activities including antimalarial, antidengue virus (DENV), and anticancer properties. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM .
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6
6 Cited Publications
Cat. No.: HY-N0205
CAS No.: 129741-57-7
Synonyms: Anemoside B4
Pulchinenoside C (Anemoside B4) is a natural compound of the herbaceous peony saponin B4, which has many biological effects, such as antitumor, neuroprotective, and anti-angiogenic activities.
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6
6 Cited Publications
Cat. No.: HY-N0359
CAS No.: 30964-13-7
Synonyms: Cynarine
Cynarin is an antichoke agent with a variety of biological activities including antioxidant, antihistamic and antiviral activities.
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6
6 Cited Publications
Cat. No.: HY-17563
CAS No.: 961-07-9
Synonyms: Deoxyguanosine; Guanine deoxyriboside
Target:  

Endogenous Metabolite

Research Areas:  

Cancer

2’-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. 2’-Deoxyguanosine can induce DNA division in mouse thymus cells. 2’-Deoxyguanosine is a potent cell division inhibitor in plant cells .
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6
6 Cited Publications
Cat. No.: HY-13557
CAS No.: 104987-12-4
Purity:  ≥98.0%
Synonyms: Immunomycin; FR-900520; FK520
Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .
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6
6 Cited Publications
Cat. No.: HY-N6947
CAS No.: 127-40-2
Synonyms: Xanthophyll
Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health . Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS) . Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active .
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6
6 Cited Publications
Cat. No.: HY-141539A
Purity:  99.77%
Research Areas:  

Cancer

SETDB1-TTD-IN-1 TFA is a potent, selective and endogenous binder competitive ligand of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD) that binds to TTD, with a Kd of 88 nM. SETDB1-TTD-IN-1 TFA increases SETDB1 methyltransferase activity. SETDB1-TTD-IN-1 TFA can be used for the research of biological functions and disease associations of SETDB1-TTD .
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6
6 Cited Publications
Cat. No.: HY-I0400
CAS No.: 131-48-6
Synonyms: NANA; Lactaminic acid
N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .
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