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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
286 Results for "
HIF1
" in MedChemExpress (MCE) Product Catalog:
Products (286)
286 Results for "HIF1" in MCE Product Catalog:
4
4 Cited Publications
Target:
Research Areas:
HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation [1].
4
4 Cited Publications
Cat. No.: HY-115903A
Purity: 99.16%
Target:
Research Areas:
HIF-1α-IN-2 hydrochloride is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 hydrochloride suppresses HIF-1α expression by blocking transcription and protein translation [1].
4
4 Cited Publications
Cat. No.: HY-P74888
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HIF1A; Basic-Helix-Loop-Helix-PAS Protein MOP1; Hypoxia Inducible Factor 1 Subunit Alpha; HIF-1-Alpha; BHLHe78; Hypoxia Inducible Factor 1 Alpha Subunit; PASD8; Hypoxia-Inducible Factor1alpha; MOP1; Member Of PAS Superfamily 1; Class E Basic Helix-Loop-Helix Protein 78; ARNT Interacting Protein; Hypoxia-Inducible Factor 1-Alpha; ARNT-Interacting Protein; PAS Domain-Containing Protein 8; HIF1-ALPHA; Member Of PAS Protein 1; HIF1-Alpha; HIF-1alpha; BHLHE78; HIF1; HIF-1A; Hypoxia Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription Factor)
Species:
Human
Source:
E. coli
4
4 Cited Publications
Cat. No.: HY-N2187
CAS No.: 43043-74-9
4
Research Areas:
Erenapursta (E3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. Erenapursta is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. Erenapursta shows anticancer activities [1] .
4
4
4 Cited Publications
Cat. No.: HY-N0390S9
CAS No.: 59681-32-2
Synonyms: L-Glutamic acid 5-amide-15N-1
3
Target:
Research Areas:
Serdemetan (JNJ-26854165) is a potent anticancer agent with radiosensitizing activity. Serdemetan exhibits antiproliferative activity in various p53 wild-type tumor cells. Serdemetan also antagonizes the Mdm2-HIF1α axis leading to decreased levels of glycolytic enzymes [1] .
3
3 Cited Publications
Research Areas:
Mitoquinol is an orally active mitochondria-targeted antioxidant. Mitoquinol can regulate mitochondrial respiration and oxidation. Mitoquinol inhibits ROS production, and improves phagocytosis and glycolysis in ethanol-exposed macrophages via the HIF-1α-PFKP axis. Additionally, Mitoquinol can partially alleviate heat stress-induced decreases in growth performance, inflammatory responses, and metabolic disorders in pigs [1] .
3
3 Cited Publications
Synonyms: Deferoxamine B (Standard); Deferriferrioxamine B (Standard); Deferrioxamine (Standard)
Target:
Reference Standards HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Apoptosis Akt Autophagy
Research Areas:
Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Deferoxamine (Standard) is the analytical standard of Deferoxamine. This product is intended for research and analytical applications. Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 [1] .
3
3 Cited Publications
Cat. No.: HY-N4185
CAS No.: 61153-77-3
2
2 Cited Publications
Cat. No.: HY-N3244
CAS No.: 123702-97-6
2
2 Cited Publications
Target:
Research Areas:
SYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis.
2
2 Cited Publications
Cat. No.: HY-P1420
CAS No.: 1446322-66-2
Target:
Research Areas:
2
2 Cited Publications
Cat. No.: HY-N3243
CAS No.: 102841-46-3
2
2 Cited Publications
Research Areas:
KPLH1130 is a pyruvate dehydrogenase kinase (PDK) inhibitor. KPLH1130 potently inhibits M1 macrophage polarization by reducing the expression of pro-inflammatory cytokines, decreasing the levels of M1 phenotype markers (HIF-1α, iNOS) and nitric oxide (NO) production. KPLH1130 prevents the reduction of mitochondrial oxygen consumption rate (OCR) induced by inflammatory stimuli (LPS ((HY-D1056) + IFN-γ) in various macrophage types. KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 can be used for the study of obesity-associated metabolic disorders and other inflammatory conditions [1].
2
2
2 Cited Publications
Synonyms: β-Sitosterol (Standard); 22,23-Dihydrostigmasterol (Standard))
2
1
1 Cited Publications
Cat. No.: HY-P2324
CAS No.: 11029-61-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
