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Results for "

CGAS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cyclic GMP-AMP Synthase (27) Adenylate Cyclase (1) AIM2 (2) Androgen Receptor (4) Apoptosis (14) Aryl Hydrocarbon Receptor (4) ATM/ATR (2) Autophagy (3) Bcl-2 Family (1) Biochemical Assay Reagents (1) Calcium Channel (1) Caspase (4) CXCR (1) Cytochrome P450 (4) DNA Stain (1) DNA/RNA Synthesis (6) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (2) Environmental Pollutants (5) Epoxide Hydrolase (1) Estrogen Receptor/ERR (2) Eukaryotic Initiation Factor (eIF) (1) Ferroptosis (1) Fungal (12) FXR (2) G-quadruplex (1) Glutathione Peroxidase (1) Glutathione S-transferase (3) Glycosyltransferase (1) Guanylate Cyclase (1) Herbicide (3) HSV (1) IFNAR (3) IKK (3) Insecticide (1) Insulin Receptor (1) Interleukin Related (3) IRAK (1) Isotope-Labeled Compounds (10) Mitochondrial Metabolism (1) mTOR (1) NF-κB (2) Parasite (4) PARP (5) PD-1/PD-L1 (3) PERK (5) Phosphatase (1) Phosphodiesterase (PDE) (1) Pregnane X Receptor (PXR) (2) PROTAC Linkers (1) PROTACs (5) Pyroptosis (1) Reactive Oxygen Species (ROS) (5) Reference Standards (7) Small Interfering RNA (siRNA) (6) Sodium Channel (1) STAT (1) STING (29) TNF Receptor (1) Toll-like Receptor (TLR) (4) Topoisomerase (2)
By Research Areas:	Cancer (34) Endocrinology (5) Infection (18) Inflammation/Immunology (41) Metabolic Disease (7) Neurological Disease (9)
Oligonucleotides:	CpG ODNs (6) Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (6)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Cyclic GMP-AMP Synthase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114180

RU.521 Maximum Cited Publications 83 Publications Verification RU320521	Cyclic GMP-AMP Synthase	Metabolic Disease
RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC₅₀ of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS) .

HY-13902

Berzosertib 20+ Cited Publications VE-822; VX-970; M6620	ATM/ATR Apoptosis STING Caspase	Infection Metabolic Disease Cancer
Berzosertib (VE-822) is an orally active, CNS-penetrant, and selective ATR kinase inhibitor. Berzosertib blocks ATR kinase activity, abrogates G₂/M cell cycle checkpoint, impairs DNA damage repair. Berzosertib induces apoptosis, inhibnits conlony migration, inhibits cell proliferation, and activates *cGAS-STING* axes in cancer cells. Berzosertib can be used for the research of cancers, such as head and neck squamous cell carcinoma, and colorectal cancer .

HY-131454

SR-717 25+ Cited Publications	STING	Inflammation/Immunology Cancer
SR-717 is a non-nucleotide STING agonist with EC₅₀s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .

HY-150751

ODN TTAGGG 3 Publications Verification ODN A151	Toll-like Receptor (TLR) AIM2 Pyroptosis Interleukin Related	Inflammation/Immunology
ODN TTAGGG (ODN A151), an inhibitory oligonucleotide (ODN), is a TLR9, AIM2, and *cGAS* antagonist. ODN TTAGGG inhibits AIM2 inflammasome activation and cGAS activation through competition with DNA. ODN TTAGGG blocks AIM2-mediated Pyroptosis and inhibits IL-18 production. ODN TTAGGG has immunosuppressive effects and can be used in research on related autoimmune diseases such as lupus erythematosus . ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3'.

HY-133916

G140 5+ Cited Publications	Cyclic GMP-AMP Synthase	Inflammation/Immunology
G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC₅₀s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity .

HY-128583

G150 5+ Cited Publications	Cyclic GMP-AMP Synthase	Inflammation/Immunology
G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC₅₀ of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory .

HY-114182

PF-06928215 3 Publications Verification	Cyclic GMP-AMP Synthase	Inflammation/Immunology
PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC₅₀ of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (K_d) .

HY-124700

LYPLAL1-IN-1 1 Publications Verification	Cyclic GMP-AMP Synthase STING PD-1/PD-L1 Epoxide Hydrolase	Metabolic Disease
LYPLAL1-IN-1 (compound 11) is a selective, covalent, and irreversible inhibitor of the lysophospholipase-like enzyme LYPLAL1 (IC₅₀ = 6 nM). LYPLAL1-IN-1 shows selectivity against other serine hydrolases such as carboxylesterase CES1 (IC₅₀ > 50 μM for CES1). LYPLAL1-IN-1 inhibits the depalmitoylation function of LYPLAL1, blocking its depalmitoylation modification of cyclic GMP-AMP synthase (cGAS), thereby promoting cGAS dimerization and activation, and initiating the cGAS-STING pathway-mediated innate immune response. LYPLAL1-IN-1 can enhance DNA-induced type I interferon production, upregulate PD-L1 expression in tumor cells, and promote the accumulation of tumor-infiltrating CD8 ⁺ T cells, with the core function of strengthening the anti-tumor immune response. LYPLAL1-IN-1 is primarily used in tumor immunology research, especially in combination with PD-1/PD-L1 inhibitors .

HY-160225

ISD sodium 4 Publications Verification	STING Interleukin Related	Inflammation/Immunology
ISD sodium is an interferon-stimulatory DNA, a 45 bp non-CpG double-stranded oligonucleotide derived from the genome of Listeria monocytogenes. ISD sodium potently induces type I interferon production via the *cGAS‑STING‑TBK1‑IRF3* pathway .

HY-P1680

Astin C Asterin	STING HSV	Infection Inflammation/Immunology Cancer
Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the *cGAS-STING* signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers .

HY-172208

*PROTAC cGAS* degrader-1**	PROTACs Cyclic GMP-AMP Synthase	Inflammation/Immunology
PROTAC cGAS degrader-1 is a potent and selective cGAS PROTAC degrader, with DC₅₀ values of 0.9 μM and 4.6 μM in THP-1 and RAW 264.7 cells, respectively. PROTAC cGAS degrader-1 induces proteasome-mediated degradation of cGAS, inhibits the cGAS signaling pathway, and attenuates double-stranded DNA-induced activation of *cGAS* in human and mouse cells. PROTAC cGAS degrader-1 is applicable to research related to ulcerative colitis .

HY-W021040

Fludioxonil CGA-173506	Environmental Pollutants Fungal Apoptosis	Infection Cancer
Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells .

HY-123230

Trifloxystrobin CGA 279202	Environmental Pollutants Fungal Caspase Apoptosis PARP	Infection Neurological Disease
Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases .

HY-150751C

ODN TTAGGG sodium 3 Publications Verification ODN A151 sodium	AIM2 Toll-like Receptor (TLR)	Inflammation/Immunology
ODN TTAGGG sodium, inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and *cGAS* antagonist. ODN TTAGGG sodium is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG sodium can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' .

HY-174801

XL-3156	Cyclic GMP-AMP Synthase	Inflammation/Immunology
XL-3156 is a *cGAS* inhibitor. XL-3156 occupies both allosteric and orthosteric sites simultaneously, and inhibits the interaction and phase separation between cGAS and DNA by stabilizing the closed conformation of the activation loop. XL-3156 can be used in the research of diseases such as autoimmune diseases and inflammation .

HY-131454A

SR-717 free acid 25+ Cited Publications	STING	Inflammation/Immunology Cancer
SR-717 free acid is a non-nucleotide STING agonist with EC₅₀s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .

HY-B1331

Cyromazine Cyromazin; CGA-72662	Environmental Pollutants Endogenous Metabolite Parasite	Neurological Disease Metabolic Disease
Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats .

HY-139056

SU0268 3 Publications Verification	Glycosyltransferase	Infection Inflammation/Immunology Cancer
SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection .

HY-114181

IRAK4-IN-4 1 Publications Verification	IRAK Cyclic GMP-AMP Synthase	Inflammation/Immunology
IRAK4-IN-4 (Compound 15) is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, with an IC₅₀ of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC₅₀ of 2.1 nM. IRAK4-IN-4 can be used for research of autoimmune diseases .

HY-141831

STF-1084	Phosphodiesterase (PDE)	Cancer
STF-1084 is a specific, cell-impermeable, competitive inhibitor of ENPP1 (K_i = 33 nM). STF-1084 increases extracellular cGAMP concentrations by preventing its degradation by ENPP1, thereby enhancing immune infiltration. STF-1084 acts synergistically with ionizing radiation (IR) and cGAMP to delay tumor progression. STF-1084 can be used to study cancers with low immunogenicity .

HY-177338

STING agonist-45	STING Cyclic GMP-AMP Synthase IFNAR TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
STING agonist-45 is a selective STING agonist (EC₅₀ = 0.28 μM). STING agonist-45 activates the innate immune response through the *cGAS-STING* pathway, upregulating key markers such as p-TBK1 and IRF3. STING agonist-45 exhibits robust STING activation in human peripheral blood mononuclear cells (PBMCs), inducing the production of type I interferons (such as IFN-β) and downstream cytokines (such as TNF-α and IL-6). STING agonist-45 enhances anti-tumor immunity, inhibits tumor growth, and increases CD8 ⁺ T cell infiltration in mouse models. STING agonist-45 is promising for the study of STING-related diseases .

HY-160546

cGAS-IN-2	Cyclic GMP-AMP Synthase	Inflammation/Immunology
cGAS-IN-2 (compound 109) is a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), with IC₅₀ of 0.01512 μM for h-cGAS .

HY-116214

Cyprodinil CGA-219417	Environmental Pollutants Aryl Hydrocarbon Receptor Androgen Receptor Fungal PERK Cytochrome P450	Infection Endocrinology
Cyprodinil (CGA-219417) is a broad-spectrum anilinopyrimidine fungicide and an activator of the aryl hydrocarbon receptor. Cyprodinil also has anti-androgenic and androgenic activities. Cyprodinil can inhibit the biosynthesis of methionine in plant-pathogenic fungi and protect fruits and vegetables from a variety of pathogens .

HY-N2616

Vomicine 1 Publications Verification	STING	Inflammation/Immunology
Vomicine modulates *cGAS-STING-TBK1* signaling pathway, and exhibits anti-inflammatory activity. Vomicine is an alkaloid that can be isolated from Strychnos nux-vomica seeds .

HY-164288

TDI-6570 TDI-006570	Cyclic GMP-AMP Synthase STING	Neurological Disease Inflammation/Immunology
TDI-6570 (TDI-006570) is a blood-brain barrier-permeable, orally active *cGAS* inhibitor with an IC₅₀ of 1.64 μM. TDI-6570 exhibits high gastrointestinal absorption and a long brain half-life in mice, and shows no toxicity to primary neurons. By inhibiting the *cGAS-STING-IFN* signaling pathway, TDI-6570 reduces STING levels and the activation of TBK1, blocks double-stranded DNA-induced *cGAS* activation and downstream interferon-stimulated gene expression, thereby reducing tau protein spread and improving synaptic loss. TDI-6570 reverses memory deficits, increases the amplitude of long-term potentiation, enhances the MEF2C transcriptional network, restores PSD-95 and vGAT punctate structures, and significantly improves cognitive resilience. TDI-6570 can be applied to the research of Alzheimer's disease, Parkinson's disease, systemic lupus erythematosus, as well as various central nervous system and autoimmune diseases .

HY-158045

PROTAC PARP1 degrader-1	PROTACs PARP	Cancer
PROTAC PARP1 degrader-1 is a PARP1 PROTAC degrader with a DC₅₀ value of 252.5 nM. PROTAC PARP1 degrader-1, combined with Daunorubicin (HY-13062A), induces the accumulation of cytoplasmic DNA fragments, activates the *cGAS/STING* innate immune pathway, and remodels the tumor microenvironment. PROTAC PARP1 degrader-1 can be used in research related to breast cancer .

HY-149526

cGAS-IN-1	Cyclic GMP-AMP Synthase	Infection Inflammation/Immunology
cGAS-IN-1 (Compound C20) is a cyclic GMP-AMP synthase (cGAS) inhibitor with IC₅₀s of 2.28 μM (human cGAS, h-cGAS ^FL) and 1.44 μM (mouse cGAS, m-cGAS ^CD). cGAS-IN-1 can be used for the studies of autoimmune diseases and chronic inflammation .

HY-P5997

XQ2B	Autophagy Cyclic GMP-AMP Synthase	Inflammation/Immunology
XQ2B is a specific *cGAS* inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection .

HY-170362

cGAS-IN-4	Cyclic GMP-AMP Synthase	Inflammation/Immunology
cGAS-IN-4 (Compound 36) is an orally active inhibitor for cyclic GMP-AMP synthase (cGAS) with IC₅₀ of 32 nM and 5.8 nM for h-cGAS and m-cGAS. cGAS-IN-4 inhibits the cGAMP in THP-1 cell with an IC₅₀ of 60 nM, which improves the cellular potency. cGAS-IN-4 exhibits anti-inflammatory efficacy in Concanavalin A (HY-P2149)-induced acute liver injury in mouse models . orally active, THP-1, C57Bl/6 mouse, orally active

HY-RS02576

CGAS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CGAS Human Pre-designed siRNA Set A contains three designed siRNAs for CGAS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CGAS Human Pre-designed siRNA Set A CGAS Human Pre-designed siRNA Set A

HY-171692

G3-YSD	Cyclic GMP-AMP Synthase IFNAR STING	Infection
G3-YSD is a *cGAS* agonist. G3-YSD directly interacts with *cGAS* to enhance its enzymatic activity, promote the conversion of ATP and GTP into cGAMP, and trigger STING-dependent IFN-α/β secretion. G3-YSD acts as a viral mimic to replace actual viral DNA . G3-YSD is applicable to research related to long COVID and type 1 human immunodeficiency virus infection .

HY-174802

XL-3158	Cyclic GMP-AMP Synthase IKK IFNAR	Neurological Disease Inflammation/Immunology Cancer
XL-3158 is a selective and cross-species Cyclic GMP-AMP synthase (cGAS) inhibitor (IC₅₀: 11.1 μM for human *cGAS, 2.19 μM for mouse cGAS). XL-3158 simultaneously occupy allosteric and orthosteric sites, stabilizing the activation loop in a closed, inactive conformation and thereby attenuating the cGAS-DNA interactions. XL-3158 inhibits cGAS* by targeting phase separation. XL-3158 efficiently penetrates cells by inhibiting aggregate formation, effectively reducing the local concentration of *cGAS* within cells. XL-3158 can be used for the study of cGAS-dependent inflammatory diseases.

HY-123230R

Trifloxystrobin (Standard) CGA 279202 (Standard)	Reference Standards Fungal Caspase PARP Apoptosis	Infection Neurological Disease
Trifloxystrobin (Standard) is the analytical standard of Trifloxystrobin. This product is intended for research and analytical applications. Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases .

HY-W020788

Benoxacor CGA 154281	Environmental Pollutants Glutathione S-transferase Estrogen Receptor/ERR Pregnane X Receptor (PXR) FXR	Metabolic Disease Cancer
Benoxacor (CGA 154281) is a herbicide safener and xenobiotic metabolism regulator. Benoxacor protects maize from the toxicity of metolachlor mainly by inducing detoxifying enzymes such as Glutathione S-transferase. Benoxacor also activates FXR, PXR and ERRα, and inhibits aromatase (aromatase). However, Benoxacor exhibits potential subacute oral toxicity and a high risk of hepatotoxicity in animal models. Benoxacor induces reactive oxygen species accumulation, interferes with embryonic heart development, and causes increased liver and kidney weights as well as alterations in gut microbiota in mice. Benoxacor can be used in studies related to hepatic steatosis, infertility, breast cancer and developmental toxicity .

HY-162459

cGAS-IN-3	Cyclic GMP-AMP Synthase	Inflammation/Immunology
cGAS-IN-3 (compound 30d-S) is an orally active cyclic GMP-AMP synthase (Cyclic GMP-AMP Synthase/cGAS) inhibitor with good plasma exposure and low clearance. cGAS-IN-3 has anti-inflammatory activity and can significantly reduce lung inflammation in rats .

HY-N15159

Cladophorol A	Cyclic GMP-AMP Synthase STING Parasite	Infection Inflammation/Immunology
Cladophorol A is a cyclic GMP-AMP synthase (cGAS) inhibitor. Cladophorol A binds to the conserved adenosine nucleobase binding site within the cGAS active site to inhibit its catalytic activity. Cladophorol A effectively inhibits the overactivation of the *cGAS-STING* pathway with an IC₅₀ of 370 nM. Cladophorol A inhibits asexual blood-stage Plasmodium falciparum with an EC₅₀ of 0.7 μg/mL. Cladophorol A can be used for the researches of inflammatory disease and malaria .

HY-144329

STING agonist-11	STING	Inflammation/Immunology Cancer
STING agonist-11 (Compound 92) is a potent small molecule cyclic urea activator of STING with EC₅₀ of 18 nM. Activation of STING is a highly promising approach in immunotherapy .

HY-179147

cGAS-IN-6	Cyclic GMP-AMP Synthase	Inflammation/Immunology
cGAS-IN-6 (14) is a *cGAS* inhibitor. cGAS-IN-6’s core structure is a fused imidazole ring system. cGAS-IN-6 can be used for research on autoimmune conditions .

HY-170362A

*(R)-cGAS-IN-4*	Cyclic GMP-AMP Synthase	Inflammation/Immunology
(R)-cGAS-IN-4 (Compound 77A) is the R-enantiomer of cGAS-IN-4 (HY-170362). cGAS-IN-4 is an orally active inhibitor for cyclic GMP-AMP synthase (cGAS*) .

HY-RS02577

Cgas Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cgas Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cgas gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cgas Mouse Pre-designed siRNA Set A Cgas Mouse Pre-designed siRNA Set A

HY-132221

CU-32	Cyclic GMP-AMP Synthase	Inflammation/Immunology
CU-32 is a potent *cGAS* inhibitor with an IC₅₀ of 0.45 µM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells .

HY-162966

MS7829	Cyclic GMP-AMP Synthase PROTACs STING	Cancer
MS7829 is a deubiquitinase-targeting chimera (DUBTAC) that targets *cGAS. MS7829 recruits OTUB1* to *cGAS, binds covalently to OTUB1, stabilizes the protein abundance of cGAS, and activates the cGAS-STING-IRF3* innate immune signaling pathway in an OTUB1-dependent manner. MS7829 is applicable to cancer-related research .

HY-116214R

Cyprodinil (Standard) CGA-219417 (Standard)	Reference Standards Fungal Androgen Receptor Aryl Hydrocarbon Receptor PERK Cytochrome P450	Infection Endocrinology
Cyprodinil (Standard) (CGA-219417 (Standard)) is the analytical standard of Cyprodinil (HY-116214). This product is intended for research and analytical applications. Cyprodinil (CGA-219417) is a broad-spectrum anilinopyrimidine fungicide and an activator of the aryl hydrocarbon receptor. Cyprodinil also has anti-androgenic and androgenic activities. Cyprodinil can inhibit the biosynthesis of methionine in plant-pathogenic fungi and protect fruits and vegetables from a variety of pathogens.

HY-P3864

Pancreastatin (37-52), human	Insulin Receptor	Metabolic Disease
Pancreastatin (37-52), human is a pancreastatin fragment. Pancreastatin a CgA-derived peptide (CgA residues 250–301) with biological activity, inhibited the releasing of insulin by islet beta cells .

HY-W681867

Fluxofenim CGA-133205	Herbicide Glutathione S-transferase	Others
Fluxofenim (CGA-133205) is a herbicide safener, with activity against Pyroxasulfone (HY-136633) and Metolachlor (HY-B1871). Fluxofenim enhances the activity of needle glutathione S-transferase (GST) towards the substrate 1-chloro-2,4-dinitrobenzene (CDNB) .

HY-118578

Furalaxyl CGA 38140	Fungal	Infection
Furalaxyl (CGA 38140) is a potent fungicide. Furalaxyl is highly selective to fungi of the order of the Peronosporales .

HY-178431

MT-44	mTOR Apoptosis Reactive Oxygen Species (ROS) STING	Cancer
MT-44 is a highly selective and potent mTOR inhibitor with an IC₅₀ of 49.4 nM. MT-44 can inhibit cancer cells proliferation, migration and invasion. MT-44 can induce cells apoptosis and ROS production and cause G2/M phase arrest. MT-44 can activate the *cGAS/STING* pathway. MT-44 can be used for the research of cancer, such as triple-negative breast cancer .

HY-159925

QKY-613	Cyclic GMP-AMP Synthase	Infection Inflammation/Immunology
QKY-613 is a prodrug that enhances immune surveillance by targeting nucleic acid modification pathways. QKY-613 promotes the selective incorporation of 6mdA (N6-methyldeoxyadenosine) into viral DNA, enhancing the phase separation potential of DNA, thereby increasing the activation of *cGAS* and strengthening host immune surveillance. In virus-infected mouse models, QKY-613 significantly reduced mortality in aged mice. QKY-613 holds promise for research on nucleic acid modification-based immune surveillance mechanisms .

HY-P990181

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) 1 Publications Verification	Glutathione Peroxidase STING	Inflammation/Immunology
Anti-Mouse myeloperoxidase/MPO Antibody (6G4) is an anti-mouse myeloperoxidase/MPO IgG2c monoclonal antibody. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) can activate the cGAS/STING pathway. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) induces acute and chronic kidney injury in mice. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) is often used in the construction of inflammation conditions models such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) .

HY-W411604

tert-Butyl hex-5-ynoate	PROTAC Linkers	Cancer
tert-Butyl hex-5-ynoate is the linker that can be used for PROTAC synthesis of PROTAC cGAS degrader-1 (HY-172208) .

Cat. No.	Product Name

HY-L237

Pattern Recognition Receptors Library

313 compounds

Pattern Recognition Receptors (PRRs) are a crucial class of protein molecules expressed in cells of the innate immune system. The core function of Pattern Recognition Receptors is to recognize Pathogen-Associated Molecular Patterns (PAMPs) and Damage-Associated Molecular Patterns (DAMPs). Upon recognizing and binding to PAMPs or DAMPs, PRRs rapidly initiate intracellular signaling pathways (such as the NF-κB, IRF, and inflammasome pathways). This triggers the production of inflammatory factors, chemokines, and type I interferons, thereby initiating inflammatory responses to eliminate pathogens or repair damage. PRRs represent the body's first line of defense against infection, and the rapidity and broad specificity of their response are crucial for host survival. However, aberrant activation of PRR signaling is also a cause of many chronic inflammatory diseases, autoimmune disorders, and neurodegenerative diseases. Therefore, precisely regulating PRR activity has become a key therapeutic strategy for these conditions.

MCE has cataloged 313 inhibitors targeting key PRRs, such as NLRs, TLRs, C-type Lectin Receptors (CLRs), and cGAS, to support drug discovery efforts for chronic inflammatory diseases.

Cat. No.	Product Name	Target	Research Area

HY-P1680

Astin C Asterin	STING HSV	Infection Inflammation/Immunology Cancer
Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the *cGAS-STING* signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers .

HY-P5997

XQ2B	Autophagy Cyclic GMP-AMP Synthase	Inflammation/Immunology
XQ2B is a specific *cGAS* inhibitor targeting protein-DNA interaction and phase separation. XQ2B markedly reduces ISD-induced Autophagy. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection .

HY-P3864

Pancreastatin (37-52), human	Insulin Receptor	Metabolic Disease
Pancreastatin (37-52), human is a pancreastatin fragment. Pancreastatin a CgA-derived peptide (CgA residues 250–301) with biological activity, inhibited the releasing of insulin by islet beta cells .

HY-P3041

Chromostatin (bovine)	Calcium Channel	Endocrinology
Chromostatin bovine is a chromogranin A (CGA) derivative peptide, which inhibits postassium or carbamoylcholine induced catecholamine release with an ID₅₀ of 5 nM. Chromostatin bovine reduces calcium flux, enhances the desensitization process of the cholinergic-evoked secretory response and modulates the endocrine response associated with catecholamine .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990181

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) 1 Publications Verification	Glutathione Peroxidase STING	Inflammation/Immunology
Anti-Mouse myeloperoxidase/MPO Antibody (6G4) is an anti-mouse myeloperoxidase/MPO IgG2c monoclonal antibody. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) can activate the cGAS/STING pathway. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) induces acute and chronic kidney injury in mice. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) is often used in the construction of inflammation conditions models such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P1680

Astin C Asterin	Natural Products Plants Compositae Erythrina latissima E. Mey. Source Classification	STING HSV
Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the *cGAS-STING* signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers .

HY-B1331

Cyromazine Cyromazin; CGA-72662	Structural Classification Natural Products Endogenous metabolite Source Classification	Environmental Pollutants Endogenous Metabolite Parasite
Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats .

HY-N2616

Vomicine 1 Publications Verification	Alkaloids Monophenols Strychnos nux-vomica Linn. Classification of Application Fields Phenols Loganiaceae Metabolic Disease Plants Disease Research Fields Indole Alkaloids Source Classification	STING
Vomicine modulates *cGAS-STING-TBK1* signaling pathway, and exhibits anti-inflammatory activity. Vomicine is an alkaloid that can be isolated from Strychnos nux-vomica seeds .

HY-N15159

Cladophorol A	Structural Classification Marine algae Marine natural products Phenols Polyphenols Source Classification	Cyclic GMP-AMP Synthase STING Parasite
Cladophorol A is a cyclic GMP-AMP synthase (cGAS) inhibitor. Cladophorol A binds to the conserved adenosine nucleobase binding site within the cGAS active site to inhibit its catalytic activity. Cladophorol A effectively inhibits the overactivation of the *cGAS-STING* pathway with an IC₅₀ of 370 nM. Cladophorol A inhibits asexual blood-stage Plasmodium falciparum with an EC₅₀ of 0.7 μg/mL. Cladophorol A can be used for the researches of inflammatory disease and malaria .

HY-B1331R

Cyromazine (Standard) Cyromazin (Standard); CGA-72662 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Parasite
Cyromazine (Standard) is the analytical standard of Cyromazine. This product is intended for research and analytical applications. Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats .

HY-N12507

Eupenicisirenin C	Microorganisms Ketones, Aldehydes, Acids Marine natural products Marine microorganism Source Classification	STING NF-κB
Eupenicisirenin C (compound 1) is a sirenin derivative. Eupenicisirenin C has strong NF-κB inhibitory activities. Eupenicisirenin C suppresses effects on *cGAS-STING* pathway. Eupenicisirenin C inhibits RANKL-induced osteoclast differentiation in bone marrow macrophage cells .

HY-N2616R

Vomicine (Standard)	Alkaloids Structural Classification Monophenols Strychnos nux-vomica Linn. Phenols Loganiaceae Plants Indole Alkaloids Source Classification	Reference Standards STING
Vomicine (Standard) is the analytical standard of Vomicine. This product is intended for research and analytical applications. Vomicine modulates *cGAS-STING-TBK1* signaling pathway, and exhibits anti-inflammatory activity. Vomicine is an alkaloid that can be isolated from Strychnos nux-vomica seeds .

Species:	Human (3) Mouse (2)
Tag:	SUMO (1) His (2) Tag Free (1) Avi (1) Flag (1)
Source:	HEK293 (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701998

	LGP2 Protein, Human (HEK293, FLAG) CGAS; Probable ATP-dependent RNA helicase DHX58; Probable ATP-dependent helicase LGP2; Protein D11Lgp2 homolog; RIG-I-like receptor 3; RLR-3; RIG-I-like receptor LGP2; RLR	Human	HEK293
	LGP2 protein is a key regulator of RIGI- and IFIH1/MDA5-mediated antiviral signaling and has dual negative and positive functions affected by factors such as infected viruses and target cells. LGP2 lacks a CARD domain for independent initiation of antiviral signaling and therefore inhibits RIG-I through multiple mechanisms, including competition for RNA binding and obstruction of interaction with MAVS/IPS1. LGP2 Protein, Human (HEK293, FLAG) is the recombinant human-derived LGP2 protein, expressed by HEK293 , with C-Flag labeled tag.

HY-P71597

	cGAS Protein, Human (His-SUMO) 1 Publications Verification C6orf150; cGAMP synthase; CGAS; CGAS_HUMAN; cGMP Synthase; Chromosome 6 open reading frame 150; Cyclic GMP-AMP synthase; h-CGAS; Hypothetical protein LOC115004; Mab 21 domain containing 1; Mab-21 domain-containing protein 1; MB21D1; MGC131892; MGC142166; MGC142168; OTTHUMP00000016743; OTTHUMP00000039330; protein MB21D1; Uncharacterized protein C6orf150	Human	E. coli
	The cGAS protein is a nucleotidyl transferase that crucially mediates innate immunity by catalyzing the formation of 2',3'-cGAMP from ATP and GTP upon binding to double-stranded DNA (dsDNA). As a DNA sensor, cGAS detects exogenous and endogenous DNA, triggering STING1 activation and type I interferon production. cGAS Protein, Human (His-SUMO) is the recombinant human-derived cGAS protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P703401

	cGAS Protein, Mouse Mb21d1	Mouse	E. coli
	cGAS Protein, Mouse is the recombinant mouse-derived cGAS protein, expressed by E. coli, with tag free tag.

HY-P703402

	cGAS Protein, Mouse (Biotinylated, Avi) Mb21d1	Mouse	E. coli
	cGAS Protein, Mouse (Biotinylated, Avi) is the recombinant mouse-derived cGAS protein, expressed by E. coli, with Avi tag.

HY-P72337

	cGAS Protein, Human (His) 3 Publications Verification Cyclic GMP-AMP synthase; cGAMP synthase; h-CGAS; 2'3'-cGAMP synthase; Mab-21 domain-containing protein 1; MB21D1; C6orf150	Human	E. coli
	cGAS is a cytosolic DNA sensor. cGAS binds double-stranded DNA (dsDNA) and catalyzes the generation of cyclic guanosine-adenylate (cGAMP), which in turn activates the STING protein. cGAS induces the production of type I interferon (IFN-I) and pro-inflammatory cytokines. cGAS Protein, Human (His) is a recombinant cGAS protein expressed in E. coli with a C-6*His tag.

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Cat. No.	Product Name	Chemical Structure

HY-123230S

Trifloxystrobin-d6
Trifloxystrobin-d₆ is the deuterium labeled Trifloxystrobin. Trifloxystrobin (CGA 279202) is a fungicide, with EC₅₀s of 23.0 μg/L and 1.7 μg/L for Daphnia magna neonate and embryos, respectively, after treatment for 48 h .

HY-W021040S

Fludioxonil-13C3
Fludioxonil- ¹³C₃ (CGA-173506- ¹³C₃) is ¹³C labeled Fludioxonil. Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells .

HY-116214S

Cyprodinil-d5

Cyprodinil-d₅(CGA-219417-d₅) is the deuterium labeled Cyprodinil (HY-116214). Cyprodinil (CGA-219417) is a broad-spectrum anilinopyrimidine fungicide and an activator of the aryl hydrocarbon receptor. Cyprodinil also has anti-androgenic and androgenic activities. Cyprodinil can inhibit the biosynthesis of methionine in plant-pathogenic fungi and protect fruits and vegetables from a variety of pathogens .

HY-116214S1

Cyprodinil-13C6

Cyprodinil- ¹³C₆ (CGA-219417- ¹³C₆) is the ¹³C₆ labeled Cyprodinil (HY-116214). Cyprodinil (CGA-219417) is a broad-spectrum anilinopyrimidine fungicide and an activator of the aryl hydrocarbon receptor. Cyprodinil also has anti-androgenic and androgenic activities. Cyprodinil can inhibit the biosynthesis of methionine in plant-pathogenic fungi and protect fruits and vegetables from a variety of pathogens .

HY-W010319S

2-Amino-4-methoxy-6-methyl-1,3,5-triazine-d3
2-Amino-4-methoxy-6-methyl-1,3,5-triazine-d₃ (CGA-150829-d₃) is deuterium labeled 2-Amino-4-methoxy-6-methyl-1,3,5-triazine .

HY-123230S1

Trifloxystrobin-d3
Trifloxystrobin-d₃ is the deuterium labeled Trifloxystrobin (HY-123230). Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases .

HY-W714168S

*(rac)-Metolachlor metabolite CGA* 351916-d3**
(rac)-Metolachlor metabolite CGA 351916-d₃ is deuterium labeled 2-((2-Ethyl-6-methylphenyl)(1-methoxypropan-2-yl)amino)-2-oxoacetic acid .

HY-W722289S

*(rac)-Metolachlor metabolite CGA* 50267-d3**
(rac)-Metolachlor metabolite CGA 50267-d₃ (N-(2-(Ethyl-2,2,2-d₃)-6-methylphenyl)-2-aminopropanoic acid) is deuterium labeled (2-Ethyl-6-methylphenyl)alanine .

HY-W289054S

*(S)-Metolachlor metabolite CGA* 50720-d3**
(S)-Metolachlor metabolite CGA 50720-d₃ (2-((2-(Ethyl-2,2,2-d₃)-6-methylphenyl)amino)-2-oxoacetic acid) is deuterium labeled 2-((2-Ethyl-6-methylphenyl)amino)-2-oxoacetic acid .

HY-W714705S

*(S)-Metolachlor metabolite CGA* 368208-d3 sodium salt**
(S)-Metolachlor metabolite CGA 368208-d₃ sodium salt (Sodium 2-((2-(ethyl-2,2,2-d₃)-6-methylphenyl)amino)-2-oxoethane-1-sulfonate) is deuterium labeled Sodium 2-((2-ethyl-6-methylphenyl)amino)-2-oxoethane-1-sulfonate .

Host:	Rabbit (2)
Reactivity:	Human (1) Mouse (1)
Application:	IHC-P (2) ICC/IF (2) IP (2) WB (2) ELISA (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2) Biotin (1)
Clonality:	Monoclonal (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86195

	cGAS Antibody (YA5887)	WB, IHC-P, ICC/IF, IP, ELISA	Mouse
	cGAS Antibody (YA5887) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to cGAS.

HY-P86480

	cGAS Antibody (YA6172)	WB, IHC-P, ICC/IF, IP, ELISA	Human
	cGAS Antibody (YA6172) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to cGAS.

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HY-150751

ODN TTAGGG 3 Publications Verification ODN A151		CpG ODNs
ODN TTAGGG (ODN A151), an inhibitory oligonucleotide (ODN), is a TLR9, AIM2, and *cGAS* antagonist. ODN TTAGGG inhibits AIM2 inflammasome activation and cGAS activation through competition with DNA. ODN TTAGGG blocks AIM2-mediated Pyroptosis and inhibits IL-18 production. ODN TTAGGG has immunosuppressive effects and can be used in research on related autoimmune diseases such as lupus erythematosus . ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3'.

HY-160225

ISD sodium 4 Publications Verification		CpG ODNs
ISD sodium is an interferon-stimulatory DNA, a 45 bp non-CpG double-stranded oligonucleotide derived from the genome of Listeria monocytogenes. ISD sodium potently induces type I interferon production via the *cGAS‑STING‑TBK1‑IRF3* pathway .

HY-150751C

ODN TTAGGG sodium 3 Publications Verification ODN A151 sodium		CpG ODNs
ODN TTAGGG sodium, inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and *cGAS* antagonist. ODN TTAGGG sodium is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG sodium can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' .

HY-RS02576

CGAS Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CGAS Human Pre-designed siRNA Set A contains three designed siRNAs for CGAS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-171692

G3-YSD		CpG ODNs
G3-YSD is a *cGAS* agonist. G3-YSD directly interacts with *cGAS* to enhance its enzymatic activity, promote the conversion of ATP and GTP into cGAMP, and trigger STING-dependent IFN-α/β secretion. G3-YSD acts as a viral mimic to replace actual viral DNA . G3-YSD is applicable to research related to long COVID and type 1 human immunodeficiency virus infection .

HY-RS02577

Cgas Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cgas Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cgas gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS02578

Cgas Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cgas Rat Pre-designed siRNA Set A contains three designed siRNAs for Cgas gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17789

Cga Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cga Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cga gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS02575

CGA Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CGA Human Pre-designed siRNA Set A contains three designed siRNAs for CGA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24257

Cga Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cga Rat Pre-designed siRNA Set A contains three designed siRNAs for Cga gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-150751A

Biotin-labeled ODN TTAGGG sodium		CpG ODNs
Biotin-labeled ODN TTAGGG (sodium), a inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and *cGAS* antagonist. Biotin-labeled ODN TTAGGG (sodium) can be used to evaluate CpG ODN cellular uptake and localization using a biotin detection system and light microscopy.

HY-150751B

FITC-labeled ODN TTAGGG sodium		CpG ODNs
FITC-labeled ODN TTAGGG (sodium), a inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and *cGAS* antagonist. FITC-labeled ODN TTAGGG (sodium) can be used to evaluate CpG ODN cellular uptake and localization by confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.

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