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1827

Inhibitors & Agonists

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145

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158

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Targets Recommended: Calcium Channel CaSR Calmodulin Calpain CRAC Channel PNPLA3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13434A

Ionomycin calcium Maximum Cited Publications 120 Publications Verification SQ23377 Calcium	Calcium Channel PKC Bacterial Apoptosis Antibiotic	Infection Cancer
Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) .

HY-Y0406E

Calcium chloride anhydrous, for cell culture 2 Publications Verification Calcium dichloride anhydrous, for cell culture	Environmental Pollutants Biochemical Assay Reagents	Infection Cancer
Calcium chloride anhydrous, for cell culture is an inorganic salt for the preparation of various buffers . Calcium chloride anhydrous, for cell culture can be used for animal modeling, to construct abdominal aortic aneurysm models .

HY-13664

Folinic acid calcium 15+ Cited Publications Leucovorin Calcium; Calcium folinate	Antifolate Endogenous Metabolite	Cancer
Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

HY-13667

Levoleucovorin Calcium 3 Publications Verification Calcium levofolinate; CL307782	Antifolate	Cancer
Levoleucovorin Calcium (Calcium levofolinate) is the active form of calcium Folinic acid (HY-13664) and has anti-tumor effects. Levoleucovorin Calcium is also a potentiator of the anti-cancer toxicity of 5-Fluorouracil (HY-90006) .

HY-Y0406H

Calcium chloride anhydrous, powder, 97% 1 Publications Verification Calcium dichloride anhydrous, powder, 97%	Environmental Pollutants Biochemical Assay Reagents	Others
Calcium chloride anhydrous, powder, 97% is an inorganic salt for the preparation of various buffers .

HY-N0681

D-Pantothenic acid hemicalcium salt 5+ Cited Publications Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 Calcium salt	Environmental Pollutants Apoptosis Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Endocrinology
D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity .

HY-B1092

Gluconate Calcium Calcium D-gluconate; Gluconic acid hemiCalcium salt	Environmental Pollutants Endogenous Metabolite Interleukin Related NO Synthase ERK	Cardiovascular Disease Inflammation/Immunology Cancer
Gluconate (D-Gluconic acid) Calcium is an orally active glucose derivative. Gluconate Calcium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate Calcium inhibits ERK phosphorylation. Gluconate Calcium has antioxidant and antiplatelet activation activities. Gluconate Calcium has antitumor activity against colorectal cancer. Gluconate Calcium improves osteoarthritis, intestinal damage and acute lung injury .

HY-17030

Acamprosate calcium Calcium N-acetylhomotaurinate	GABA Receptor iGluR	Neurological Disease
Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.

HY-108536D

Calcium chloride dihydrate, for cell culture, 99%	Biochemical Assay Reagents	Others
Calcium chloride dihydrate, for cell culture, 99% is a biochemical reagent. Calcium chloride dihydrate, for cell culture, 99% enhances the dentinogenic differentiation potential of WMTA on cells. Calcium chloride dihydrate, for cell culture, 99% can be used as a biological material or organic compound for life science related research ^[2.

HY-107929

Calcium polystyrene sulfonate Poly(styrenesulfonic acid) Calcium salt	Potassium Channel	Metabolic Disease
Calcium polystyrene sulfonate (Poly(styrenesulfonic acid) calcium salt) is an orally active potassium-lowering agent. Calcium polystyrene sulfonate binds potassium in the distal colon in exchange for Ca ²⁺. Calcium polystyrene sulfonate can be used for the research of hyperkalemia in chronic kidney disease .

HY-111603

Calcium dobesilate 1 Publications Verification	Apoptosis	Metabolic Disease Inflammation/Immunology
Calcium dobesilate is a vascular protector with oral activity that can clear hydroxyl free radicals, with an IC₅₀ of 1.1 pM. Calcium dobesilate has antioxidant activity and helps to reduce oxidative stress and inflammation in the retinas of diabetic mice. Calcium dobesilate can be used to study chronic venous diseases, diabetic retinopathy, and the occurrence of hemorrhoids, among other conditions .

HY-N2582

Calcium Phytate 1 Publications Verification Phytin	Endogenous Metabolite	Metabolic Disease
Calcium phytate (Phytin) is an insoluble phosphorus-containing compound widely present in plant-based foods such as cereals and legumes. Calcium phytate can be found in feces and can alleviate lead poisoning .

HY-128370

Calcium trinatrium diethylenetriaminepentaacetic acid hydrate Ca-DTPA trisodium salt hydrate	CMV	Infection
Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) is a metal chelator and a useful antidote (such as acute cadmium intoxication). Diethylenetriaminepentaacetic acid calcium trisodium salt hydrate is a nontoxic inhibitor of CMV replication .

HY-W243408C

Calcium carbonate, 99% Limestone, 99%	Environmental Pollutants Biochemical Assay Reagents	Others
Calcium carbonate, 99% (Limestone, 99%) is a calcium carbonate salt and also a mineral. Calcium carbonate, 99% serves as a thickener and acidity regulator .

HY-W009208

Calcium L-Threonate 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Calcium L-Threonate, a calcium aldonate, is a calcium supplement. Calcium L-Threonate can be used for the study of osteoporosis .

HY-17557

Calcium N5-methyltetrahydrofolate 5+ Cited Publications NSC173328; 5-Methyl THF Calcium	Drug Derivative	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Calcium N5-methyltetrahydrofolate (NSC173328; 5-Methyl THF (calcium)), Levomefolic acid (HY-14781) derivative, is a folic acid supplement. Calcium N5-methyltetrahydrofolate can be used for the research of neural tube defects, infertility, non-hodgkin's lymphoma, endometriosis .

HY-D1631

Calcium Green-5N AM	Fluorescent Dye Calcium Channel	Neurological Disease
Calcium Green-5N AM is a Ca ²⁺-sensitive fluorescent probe (K_d = 14 μM). Calcium Green-5N AM shows enhanced fluorescence intensity upon binding to Ca ²⁺, and it can monitor free Ca ²⁺ in neurons .

HY-136460

Calcium ionophore I ETH 1001	Calcium Channel	Others
Calcium ionophore I (ETH 1001) is a selective Ca ²⁺ ionophore for biological membranes. Calcium ionophore I can be used in Ca2+-selective microelectrodes that can be used for quantitative intracellular measurements of resting Ca2+-activities and of slowly changing Ca2+-levels .

HY-W145486

Calcium gluconate	Environmental Pollutants Biochemical Assay Reagents	Neurological Disease Metabolic Disease Inflammation/Immunology
Calcium gluconate is an orally effective calcium salt supplement . Calcium gluconate reduces elevated serum potassium, decreased serum calcium, and postoperative myalgia associated with succinylcholine administration. Calcium gluconate restores calcium homeostasis, skeletal integrity, bone mineralization and bone density, and maintains levels of parathyroid hormone, bone resorption markers and osteoclasts. Calcium gluconate reverses LPS (HY-D1056)-induced ERK phosphorylation, inflammatory cytokine release and acute lung injury, alleviates airway inflammatory damage and suppresses immune responses. Calcium gluconate can be used in research related to postoperative myalgia, osteoporosis/osteomalacia and acute lung injury .

HY-N0666B

Aspartic acid calcium 4 Publications Verification Calcium L-aspartate	Endogenous Metabolite	Inflammation/Immunology
Aspartic acid calcium (Calcium L-aspartate) is a chelate where calcium is attached to an amino acid naming L-Aspartic acid. L-Aspartic aicd calcium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd calcium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd calcium commonly used in the study of inflammatory conditions .

HY-D1176

Calcium Green 1AM	Fluorescent Dye	Others
Calcium Green 1AM is a cell-permeant *fluorescent calcium* indicator** (Excitation 506 nm; Emission 531 nm). Calcium Green 1AM is converted to the fluorescent calcium indicator by intracellular esterases .

HY-Y0708

Calcium hydrogen phosphate dihydrate Calcium phosphate dihydrate	Biochemical Assay Reagents	Others
Calcium hydrogen phosphate dihydrate (Calcium phosphate dihydrate) can be found quite frequently in urinary calculi stones. Calcium hydrogen phosphate dihydrate can be used as an excipient, such as diluent, adsorbent. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .

HY-W133967

Calcium alginate	Environmental Pollutants Biochemical Assay Reagents	Inflammation/Immunology
Calcium alginate is a biopolymer that can be used for developing oral agent-delivery systems . Calcium alginate is a pH sensitive hydrogel stable in acidic media and soluble in basic media .

HY-W013636B

Calcium 2-oxoglutarate 5+ Cited Publications	Tyrosinase Endogenous Metabolite	Metabolic Disease
Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-D1629

Calcium Orange AM	Fluorescent Dye	Others
Calcium Orange AM is an intracellular calcium reporter. Specific fluorescence can be detected when free calcium binds to Calcium Orange AM (Ex/Em=549/576 nm). Calcium Orange AM does not enter the vacuoles and does not compartmentalize into acidic vesicles .

HY-B2242

Calcium phosphate Secondary Calcium	Biochemical Assay Reagents	Others
Calcium phosphate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-B2219A

Calcium stearate 20+ Cited Publications	Environmental Pollutants Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Calcium stearate is an orally active long-chain dietary saturated fatty acid that can significantly reduce visceral fat by inducing apoptosis of preadipocytes. Calcium stearate can be used in the study of cardiovascular and metabolic diseases .

HY-Y0287AS

Calcium carbonate,99.8%,PT-13c	Isotope-Labeled Compounds	Others
Calcium carbonate,99.8%,PT- ¹³C is the ¹³C labeled Calcium carbonate,99.95-100.05%,PT .

HY-W243408D

Calcium carbonate, for cell culture Limestone, for cell culture	Biochemical Assay Reagents	Others
Calcium carbonate, for cell culture (Limestone, for cell culture) is a thickener and acidity regulator. Calcium carbonate, for cell culture is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W250119

Calcium disodium edetate hydrate 20+ Cited Publications EDTA disodium Calcium salt hydrate; Ethylenediaminetetraacetic acid disodium Calcium salt hydrate	Biochemical Assay Reagents Fungal Mitochondrial Metabolism	Infection
Calcium disodium edetate hydrate (EDTA disodium calcium salt hydrate) is a metal chelator and antifungal agent. Calcium disodium edetate hydrate chelates Mn ²⁺, damages mitochondria, and interferes with carbohydrate metabolic pathways, particularly the synthesis of pyruvate in glycolysis. Calcium disodium edetate hydrate inhibits Penicillium digitatum and delays conidial germination. Calcium disodium edetate (hydrate) enhances the host defense system of citrus fruits. Calcium disodium edetate hydrate is applicable to research related to citrus green mold .

HY-115429

Calcium dextrofolinate (6R)-Leucovorin Calcium; (6R)-Folinic acid Calcium	Drug Derivative	Metabolic Disease
Calcium dextrofolinate is a stereoisomer of Calcium folinate. Calcium folinate (Folinic acid calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

HY-W094707

Calcium phosphate monobasic monohydrate 1 Publications Verification Calcium superphosphate	Biochemical Assay Reagents	Others
Calcium phosphate monobasic monohydrate (Calcium superphosphate) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-B2233AS

Calcium phosphorylcholine-d9 chloride Phosphocholine-d9 chloride Calcium	Endogenous Metabolite Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Calcium phosphorylcholine-d₉ (chloride) is the deuterium labeled Calcium phosphorylcholine chloride. Calcium phosphorylcholine chloride is the main phospholipid component in eukaryotic biofilms. Calcium phosphorylcholine chloride exists in commensal or pathogenic bacteria associated with eukaryotes in prokaryotes. Calcium phosphorylcholine chloride exhibits a surprising range of immunomodulatory properties .

HY-W094349A

Calcium silicate, 99% Silicic acid, Calcium salt	Environmental Pollutants Biochemical Assay Reagents	Others
Calcium silicate, 99% (Silicic acid, calcium salt) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W540188A

Calcium mesoxalate trihydrate Ketomalonic acid Calcium trihydrate; Mesoxalic acid Calcium trihydrate; Oxomalonic acid Calcium trihydrate	Biochemical Assay Reagents	Metabolic Disease
Calcium mesoxalate trihydrate (Ketomalonic acid; Mesoxalic acid; Oxomalonic acid) can promote B cell proliferation and has potential anti-diabetic activity. Derivatives of Calcium mesoxalate trihydrate also inhibit the translocation of HIC-1 reverse transcriptase .

HY-111603R

Calcium dobesilate (Standard)	Reference Standards Apoptosis	Others
Calcium dobesilate (Standard) is the analytical standard of Calcium dobesilate. This product is intended for research and analytical applications. Calcium dobesilate, a vasoprotective, is widely used in chronic venous disease, diabetic retinopathy and the symptoms of haemorrhoidal attack in many countries.

HY-B2217D

Calcium hydroxide, ACS, 95%	Bacterial Biochemical Assay Reagents	Inflammation/Immunology
Calcium hydroxide, ACS, 95% has high bactericidal activity and high pH. Calcium hydroxide, ACS, 95% has ability to induce hard tissue formation. Calcium hydroxide, ACS, 95% can dissociate into calcium (Ca) and hydroxyl ions (OH). Calcium hydroxide, ACS, 95% has the potential for intra-canal medicament research .

HY-B2233A

Calcium phosphorylcholine chloride, 98% 10+ Cited Publications	Biochemical Assay Reagents Adrenergic Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Calcium phosphorylcholine chloride, 98% is the main phospholipid component in eukaryotic biofilms. Calcium phosphorylcholine chloride, 98% exists in commensal or pathogenic bacteria associated with eukaryotes in prokaryotes. Calcium phosphorylcholine chloride, 98% exhibits a surprising range of immunomodulatory properties .

HY-W019972

Calcium pyrophosphate	Biochemical Assay Reagents	Others
Calcium pyrophosphate is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-W094350

Calcium sulfate dihydrate (99%) Gypsum fibrosum (99%)	Environmental Pollutants Biochemical Assay Reagents	Others
Calcium sulfate dihydrate (99%) (Gypsum fibrosum (99%)) is a desiccant. Calcium sulfate dihydrate (99%) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-139728

N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide Calcium ionophore II	Biochemical Assay Reagents	Others
N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide (Calcium ionophore II) is a lipophilic ionophore that can be used in preparing calcium ion-selective electrode .

HY-50713

Calcium-Sensing receptor antagonist I	CaSR	Others
Calcium-Sensing receptor antagonist I is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W749867

Ca(II)-EDTA disodium dihydrate Calcium disodium EDTA dihydrate	Bacterial	Infection Others
CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis . CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning .

HY-128749A

D-Glucaric acid tetrahydrate Calcium D-glucarate tetrahydrate	Endogenous Metabolite Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
D-Glucaric acid tetrahydrate (Calcium D-glucarate tetrahydrate) is an orally active end product of the mammalian D-glucuronidation pathway. D-Glucaric acid tetrahydrate is found in a variety of fruits and vegetables. D-Glucaric acid tetrahydrate induces cell Apoptosis. D-Glucaric acid tetrahydrate reduces the expression of hippocampal myelin-related genes (Mbp, Plp1). D-Glucaric acid tetrahydrate has cholesterol-lowering and anti-tumor activities. D-Glucaric acid tetrahydrate can be used in the research of neurological diseases .

HY-B2200

Calcium citrate tetrahydrate, 99% TriCalcium dicitrate tetrahydrate, 99%	Environmental Pollutants Biochemical Assay Reagents Calcium Channel	Metabolic Disease
Calcium citrate tetrahydrate, 99% exhibits the ability to release more calcium ions in a short time therefore allowing a high activity, and a high concentration of calcium ions that can stimulate bone formation .

HY-W094353

Calcium acetate hydrate	Biochemical Assay Reagents	Others
Calcium acetate hydrate is a type of calcium salt that can be used as a food additive, stabilizer, buffer and isolator. Calcium acetate hydrate can be combined with phosphate in the diet to reduce phosphate levels in the blood .

HY-B1580

Calcium propionate Propionic acid Calcium	Environmental Pollutants Biochemical Assay Reagents	Metabolic Disease
Calcium propionate is an orally active auxiliary agent for preventing milk fever and improving the health of dairy cows. Calcium propionate can be used for research on dairy cow milk fever and subclinical hypocalcemia .

HY-Y0262D

*Oxalic acid calcium* monohydrate,99%** Calcium oxalate dihydrate	Biochemical Assay Reagents	Others
Oxalic acid (calcium monohydrate),99% (Calcium oxalate dihydrate) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W019962

Calcium fluoride 1 Publications Verification	Biochemical Assay Reagents	Others
Calcium fluoride is a kind of biological materials or organic compounds that are widely used in life science research .

HY-B2227D

Calcium 2-hydroxypropanoate pentahydrate 10+ Cited Publications	Environmental Pollutants Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cancer
Calcium 2-hydroxypropanoate (pentahydrate) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Calcium 2-hydroxypropanoate (pentahydrate) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Calcium 2-hydroxypropanoate (pentahydrate) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13434

Ionomycin Maximum Cited Publications 120 Publications Verification SQ23377	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .

HY-N6687

Calcimycin 20+ Cited Publications A-23187; Antibiotic A-23187	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Polyether Antibiotics Source Classification	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis and autophagy .

HY-B0351

Taurine 15+ Cited Publications 2-Aminoethanesulfonic acid	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification Cancer	Autophagy Endogenous Metabolite
Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes .

HY-13434A

Ionomycin calcium Maximum Cited Publications 120 Publications Verification SQ23377 Calcium	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) .

HY-N0378

D-Mannitol 10+ Cited Publications Mannitol; Mannite	Structural Classification Natural Products other families Classification of Application Fields Metabolic Disease Plants Endogenous metabolite Disease Research Fields Sweeteners Source Classification Food Research	Environmental Pollutants Endogenous Metabolite Apoptosis PGC-1α PKA Adrenergic Receptor
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells . D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed .

HY-13664

Folinic acid calcium 15+ Cited Publications Leucovorin Calcium; Calcium folinate	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Antifolate Endogenous Metabolite
Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

HY-B1357

Digitoxin 5+ Cited Publications	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Classification of Application Fields Scrophulariaceae Plants Disease Research Fields Steroids Source Classification	Environmental Pollutants Apoptosis Na+/K+ ATPase Bcl-2 Family Caspase HSV Calcium Channel
Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .

HY-13667

Levoleucovorin Calcium 3 Publications Verification Calcium levofolinate; CL307782	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Antifolate
Levoleucovorin Calcium (Calcium levofolinate) is the active form of calcium Folinic acid (HY-13664) and has anti-tumor effects. Levoleucovorin Calcium is also a potentiator of the anti-cancer toxicity of 5-Fluorouracil (HY-90006) .

HY-N0681

D-Pantothenic acid hemicalcium salt 5+ Cited Publications Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 Calcium salt	Structural Classification Natural Products other families Classification of Application Fields Other Diseases Plants Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Apoptosis Endogenous Metabolite
D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity .

HY-B1174

Bekanamycin Kanamycin B	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain .

HY-B1092

Gluconate Calcium Calcium D-gluconate; Gluconic acid hemiCalcium salt	Structural Classification Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Source Classification	Environmental Pollutants Endogenous Metabolite Interleukin Related NO Synthase ERK
Gluconate (D-Gluconic acid) Calcium is an orally active glucose derivative. Gluconate Calcium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate Calcium inhibits ERK phosphorylation. Gluconate Calcium has antioxidant and antiplatelet activation activities. Gluconate Calcium has antitumor activity against colorectal cancer. Gluconate Calcium improves osteoarthritis, intestinal damage and acute lung injury .

HY-N0470

L-Lysine hydrochloride 5+ Cited Publications	Cardiovascular Disease Microorganisms Animals Classification of Application Fields Amino acids Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Virus Protease Endogenous Metabolite
L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

HY-32343

Secalciferol 5+ Cited Publications (24R)-24,25-Dihydroxyvitamin D3	Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Endogenous Metabolite VD/VDR
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC₅₀ value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders .

HY-B0080

*Folinic acid calcium* salt pentahydrate** 15+ Cited Publications Leucovorin Calcium salt pentahydrate	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Antifolate Endogenous Metabolite
Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

HY-Y0095

Isethionic acid (80% in water) 2-Hydroxyethanesulfonic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Marine natural products Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Mitochondrial Metabolism Parasite
Isethionic acid is a calcium binder and anionic detergent that enhances mitochondrial calcium binding capacity by competitively binding to calcium binding sites on the outer mitochondrial membrane. Isethionic acid can inhibit calcium-activated mitochondrial respiration. Isethionic acid inhibits barnacle (Balanus amphitrite) larvae with LC₅₀s of 23 μg/mL (24 h) and 17 μg/mL (48 h), respectively. Isethionic acid can inhibit the attachment of barnacle larvae (complete inhibition at 10 μg/mL) and regulate mitochondrial calcium transport, and can enhance ATP-dependent calcium uptake at high calcium concentrations. Isethionic acid can be used to study the mechanism of mitochondrial calcium metabolism.

HY-W015954

(2R,3R)-Butane-2,3-diol	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Calcium Channel Bacterial
(2R,3R)-Butane-2,3-diol is a non-covalent, reversible agonist targeting lanthanum (La ³⁺)-sensitive calcium channels in bacteria (e.g., Escherichia coli) with an EC₅₀ of approximately 25 mM. (2R,3R)-Butane-2,3-diol binds to calcium channel proteins or related complexes, induces channel opening, promotes extracellular calcium influx, and triggers intracellular calcium transients, which may regulate bacterial physiological activities such as growth, metabolism, and signal transduction. (2R,3R)-Butane-2,3-diol mediates bacterial-host cell signaling interactions and affects the metabolic balance of intestinal microorganisms, and can be used to study lactose intolerance and other related diseases .

HY-12546

Brevetoxin B Brevetoxin-2; PbTx-2	Structural Classification Natural Products Microorganisms Animals Source Classification	Sodium Channel Apoptosis Calcium Channel Potassium Channel Caspase
Brevetoxin B (Brevetoxin-2) is a red tide toxin. Brevetoxin B affects sodium, potassium and *calcium* currents in nerve terminals. Brevetoxin B also modulates the metabolic activity of Jurkat cells, reduces cell viability and induces apoptosis. Brevetoxin B can be used in research on synaptic transmission and tumors .

HY-W074890

Palmitoylglycine 1 Publications Verification N-palmitoyl glycine	Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Calcium Channel NO Synthase
Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA .

HY-W032013

1-Octanol 1 Publications Verification Octanol	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Environmental Pollutants Endogenous Metabolite Calcium Channel
1-Octanol (Octanol), a saturated fatty alcohol, is a *T-type calcium* channels (T-channels) inhibitor with an IC₅₀** of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

HY-N2582

Calcium Phytate 1 Publications Verification Phytin	Natural Products other families Classification of Application Fields Other Diseases Plants Disease Research Fields Source Classification	Endogenous Metabolite
Calcium phytate (Phytin) is an insoluble phosphorus-containing compound widely present in plant-based foods such as cereals and legumes. Calcium phytate can be found in feces and can alleviate lead poisoning .

HY-N0378R

D-Mannitol (Standard) 10+ Cited Publications Mannitol(Standard); Mannite (Standard)	Structural Classification Natural Products Microorganisms other families Classification of Application Fields Metabolic Disease Plants Endogenous metabolite Disease Research Fields Sweeteners Source Classification Food Research	Reference Standards Endogenous Metabolite Apoptosis PGC-1α Adrenergic Receptor PKA
D-Mannitol (Standard) is the analytical standard of D-Mannitol (HY-N0378). This product is intended for research and analytical applications. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells . D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed .

HY-A0191

Dexbrompheniramine (+)-Brompheniramine; (S)-Brompheniramine	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite Histamine Receptor TRP Channel
Dexbrompheniramine ((+)-Brompheniramine; (S)-Brompheniramine) is a dual inhibitor of histamine H1 receptor and TRPV1 receptor that can cross the blood-brain barrier. Dexbrompheniramine exerts its effects by functionally blocking H1 receptor activity and dose-dependently inhibiting TRPV1-mediated calcium responses, including Capsaicin (HY-10448)-induced responses. The combination of Dexbrompheniramine with Cimetidine (HY-14289) eliminates histamine-induced and sham-feeding-induced drinking behavior, whereas Dexbrompheniramine alone does not induce thirst or alter sham-feeding behavior in rats. Dexbrompheniramine can be used in the research of chronic cough and related pathological mechanisms .

HY-N7395

Cyclic ADP-ribose 1 Publications Verification cADPR	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Calcium Channel TRP Channel Endogenous Metabolite
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-N0546

Ligustroflavone 2 Publications Verification Nuezhenoside	Flavonoids Oleaceae Classification of Application Fields Flavones Ligustrum lucidum Ait. Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	CaSR RIP kinase Mixed Lineage Kinase TGF-beta/Smad
Ligustroflavone is an orally active flavonoid compound. Ligustroflavone can be extracted from Ligustrum lucidum. Ligustroflavone antagonizes the calcium-sensing receptor (CaSR), inhibits the RIPK1/RIPK3/MLKL pathway, and downregulates TGF-β/Smad signaling. Ligustroflavone regulates calcium metabolism, protects bone tissue, reduces cerebral ischemic injury, and inhibits liver fibrosis. Ligustroflavone can be used in the study of diabetic osteoporosis, ischemic stroke, and liver fibrosis .

HY-W009208

Calcium L-Threonate 1 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Calcium L-Threonate, a calcium aldonate, is a calcium supplement. Calcium L-Threonate can be used for the study of osteoporosis .

HY-17431

*Fosamprenavir Calcium* Salt** 4 Publications Verification GW433908G	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate HIV HIV Protease
Fosamprenavir Calcium Salt (GW433908G) is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir Calcium Salt is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir Calcium Salt can be used for the study of human immunodeficiency virus (HIV-1) infection .

HY-113285

Ureidopropionic acid 3-Ureidopropionic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields	Oxidative Phosphorylation
Ureidopropionic acid is a mitochondrial respiratory chain complex V inhibitor that selectively inhibits the activity of mitochondrial respiratory chain complex V, with no effect on respiratory chain complexes I-IV or mitochondrial fatty acid β-oxidation. Ureidopropionic acid induces the production of reactive oxygen species, delayed elevation of intracellular calcium concentration, secondary energy-dependent excitotoxicity and neurodegeneration in neurons. Ureidopropionic acid promotes neuropathological changes by impairing mitochondrial energy metabolism, oxidative stress and excitotoxicity pathways. Ureidopropionic acid can be used in studies related to 3-ureidopropionase deficiency and severe propionic aciduria .

HY-N0666B

Aspartic acid calcium 4 Publications Verification Calcium L-aspartate	Cardiovascular Disease Microorganisms other families Animals Classification of Application Fields Amino acids Plants Disease Research Fields Source Classification	Endogenous Metabolite
Aspartic acid calcium (Calcium L-aspartate) is a chelate where calcium is attached to an amino acid naming L-Aspartic acid. L-Aspartic aicd calcium is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd calcium is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd calcium commonly used in the study of inflammatory conditions .

HY-N7068

*Mupirocin calcium* hydrate** 1 Publications Verification BRL-4910A Calcium hydrate; Pseudomonic acid Calcium hydrate	Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Inflammation/Immunology Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic
Mupirocin (BRL-4910A, Pseudomonic acid) calcium hydrate is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin calcium hydrate apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis .

HY-W013636B

Calcium 2-oxoglutarate 5+ Cited Publications	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Tyrosinase Endogenous Metabolite
Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-N6066

Praeruptorin E	Cardiovascular Disease Classification of Application Fields Coumarins Salvia hypargeia Fisch. & C.A.Mey. Phenylpropanoids Umbelliferae Plants Disease Research Fields Source Classification	Calcium Channel
Praeruptorin E is a main bioactive constituent of Peucedanum praeruptorum (also known as Bai-Hua Qian Hu). Praeruptorin C is a *calcium* antagonist with pD₂ ^′ value of 5.2 .

HY-N6036

Ganoderic acid F 1 Publications Verification	Triterpenes Microorganisms Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Source Classification Cancer	Others
Ganoderic acid F is a ganoderic acid. Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium signaling, and endoplasmic reticulum stress .

HY-B2219A

Calcium stearate 20+ Cited Publications	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants Endogenous Metabolite
Calcium stearate is an orally active long-chain dietary saturated fatty acid that can significantly reduce visceral fat by inducing apoptosis of preadipocytes. Calcium stearate can be used in the study of cardiovascular and metabolic diseases .

HY-Y0569B

*D-Gluconic acid calcium* hydrate** 1 Publications Verification	Classification of Application Fields Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Source Classification Cancer	Fungal Endogenous Metabolite
D-Gluconic acid calcium hydrate is the carboxylic acid by the oxidation with antiseptic and chelating properties.

HY-N2005

Cycleanine	Alkaloids Classification of Application Fields Plants Cissampelos pareira Menispermaceae Inflammation/Immunology Disease Research Fields Alkaloid Dimers Source Classification	Calcium Channel Apoptosis
Cycleanine is a potent vascular selective *Calcium* antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway .

HY-N3463

Isopimaric acid	Other Terpenoids Pinus nigra Arn. Pinaceae Terpenoids Plants Source Classification	Potassium Channel
Isopimaric acid is a potent opener of *large conductance calcium* activated K ⁺ (BK) channels**.

HY-107301

Dehydrosoyasaponin I Soyasaponin Be; DHS-I	Triterpenes Structural Classification Leguminosae Terpenoids Plants Pentacyclic Triterpenoids Medicago sativa L. Source Classification	Potassium Channel
Dehydrosoyasaponin I (Soyasaponin Be;DHS-I), a triterpene glycoside, is a potent and reversible calcium-activated potassium (maxi-K) channels activator .

HY-N2060

Evocarpine	Infection Alkaloids Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Rutaceae Quinoline Alkaloids Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Bacterial
Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca ²⁺ influx through voltage-dependent calcium channels. Antimycobacterial activity .

HY-W011249

*Phosphorylcholine chloride calcium* salt tetrahydrate** 10+ Cited Publications	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Phosphorylcholine chloride calcium salt tetrahydrate is an endogenous metabolite.

HY-15830

25,26-Dihydroxyvitamin D3 25,26-Dihydroxycholecalciferol	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	VD/VDR Drug Metabolite Drug Derivative Calcium Channel
25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a dihydroxylated derivative and metabolite of Vitamin D3 (HY-15398). 25,26-Dihydroxyvitamin D3 moderately increases serum calcium levels when the initial serum calcium level is low. 25,26-Dihydroxyvitamin D3 promotes intestinal calcium absorption in vitamin D-deficient rats fed a low-calcium diet. 25,26-Dihydroxyvitamin D3 is applicable to research related to osteomalacia .

HY-128749A

D-Glucaric acid tetrahydrate Calcium D-glucarate tetrahydrate	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Apoptosis
D-Glucaric acid tetrahydrate (Calcium D-glucarate tetrahydrate) is an orally active end product of the mammalian D-glucuronidation pathway. D-Glucaric acid tetrahydrate is found in a variety of fruits and vegetables. D-Glucaric acid tetrahydrate induces cell Apoptosis. D-Glucaric acid tetrahydrate reduces the expression of hippocampal myelin-related genes (Mbp, Plp1). D-Glucaric acid tetrahydrate has cholesterol-lowering and anti-tumor activities. D-Glucaric acid tetrahydrate can be used in the research of neurological diseases .

HY-138875

Tetraacetylphytosphingosine	Natural Products Microorganisms Source Classification	p38 MAPK Apoptosis
Tetraacetylphytosphingosine is a sphingolipid metabolite produced by phytosphingosine acetylation. Tetraacetylphytosphingosine exerts its inhibitory action on angiogenesis through the inhibition of MAPK activation and intracellular calcium increase . Tetraacetylphytosphingosine induces apoptosis in HaCaT cells .

HY-N3741

Didrovaltrate Didrovaltratum	Structural Classification Natural Products Classification of Application Fields Valeriana officinalis Linn. Plants Valerianaceae Disease Research Fields Source Classification Cancer	Calcium Channel Reactive Oxygen Species (ROS) Autophagy
Didrovaltrate (Didrovaltratum) is an *L-type calcium* channel blocker, ROS scavenger, autophagy** enhancer, and lipid accumulation inhibitor. Didrovaltrate blocks L-type calcium currents in a concentration-dependent manner, shifts the current-voltage curve upward, modulates steady-state inactivation kinetics, and inhibits the nuclear translocation of glucocorticoid receptors. Didrovaltrate reduces ROS levels, downregulates the expression of muscle atrophy-related genes, enhances autophagy via lipophagy, and decreases Oleic acid-induced lipid accumulation. Didrovaltrate exhibits cytotoxic activity against cancer cells. Didrovaltrate can be used in research related to skeletal muscle atrophy, non-alcoholic fatty liver disease, breast cancer, lung cancer, gastric cancer, and prostate cancer .

HY-N7875

Celangulin	Natural Products Celastraceae Celastrus angulatus Maxim. Plants Source Classification	Others
Celangulin is an insecticidal component isolated from Celastrus angulatus. Celangulin activates the calcium channel on the plasma membrane with increasing the intracellular Ca ²⁺ after influx from the external. Celangulin activates the calcium channel in the ER .

HY-101546A

Cavidine (+)-Cavidine	Structural Classification Alkaloids Corydalis yanhusuo W. T. Wang Plants Isoquinoline Alkaloids Papaveraceae Source Classification	p38 MAPK ERK Interleukin Related
Cavidine ((+)-Cavidine) is an analgesic and anti-inflammatory agent. Cavidine can be isolated from Corydalis ternata f. yanhusuo (Y.H.Chou & Chun C.Hsu) Y.C.Zhu. Cavidine reduces the expression of inflammatory factors IL-1β, IL-6 and TNF-α, and inhibits calcium ion influx. Cavidine inhibits the phosphorylation of p38 and ERK1/2. Cavidine increases mechanical and thermal pain thresholds in chronic pain models. Cavidine can be used for the research of chronic pain .

HY-N7395A

Cyclic ADP-ribose ammonium 1 Publications Verification cADPR ammonium	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Calcium Channel TRP Channel Endogenous Metabolite
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-N8251

Cyclocurcumin	Phenols Polyphenols Plants Curcuma longa Source Classification Zingiberaceae	p38 MAPK
Cyclocurcumin is a potent p38α inhibitor. Cyclocurcumin shows antirheumatic, antivasoconstrictive and antioxidant activities .

HY-N0681R

D-Pantothenic acid hemicalcium salt (Standard) Calcium pantothenate (Standard); Calcium D-pantothenate (Standard); Vitamin B5 Calcium salt (Standard)	Structural Classification Natural Products other families Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Apoptosis
D-Pantothenic acid (hemicalcium salt) (Standard) is the analytical standard of D-Pantothenic acid (hemicalcium salt). This product is intended for research and analytical applications. D-Pantothenic acid hemicalcium salt is a vitamin that reduces patulin in apple juice.

HY-W011195

Calcium 2-hydroxy-4-(methylthio)butanoate	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Calcium 2-hydroxy-4-(methylthio)butanoate is an endogenous metabolite.

HY-W074890R

Palmitoylglycine (Standard) N-palmitoyl glycine (Standard)	Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Calcium Channel NO Synthase
Palmitoylglycine (Standard) is the analytical standard of Palmitoylglycine. This product is intended for research and analytical applications. Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA[1][2][3].

Cat. No.	Product Name	Chemical Structure

HY-N0470S3

L-Lysine-13C6,15N2 hydrochloride
L-Lysine- ¹³C₆, ¹⁵N₂ (hydrochloride) is the ¹³C- and ¹⁵N-labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

HY-100807S

Quinolinic acid-d3 2 Publications Verification
Quinolinic acid-d₃ is the deuterium labeled Quinolinic acid. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.

HY-B0351S

Taurine-d4 1 Publications Verification
Taurine-d₄ is the deuterium labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes .

HY-B0284S

Nifedipine-d6
Nifedipine-d₆ (BAY-a-1040-d₆) is deuterium labeled nifedipine, and nifedipine is a potent calcium channel blocker.

HY-N0470S6

L-Lysine-d4 hydrochloride
L-Lysine-d₄ (hydrochloride) is the deuterium labeled L-Lysine. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

HY-B0351S2

Taurine-13C2,15N
Taurine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N- labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes .

HY-Y0287AS

Calcium carbonate,99.8%,PT-13c
Calcium carbonate,99.8%,PT- ¹³C is the ¹³C labeled Calcium carbonate,99.95-100.05%,PT .

HY-N0470S8

L-Lysine-13C6 hydrochloride
L-Lysine- ¹³C₆ hydrochloride is the ¹³C labeled L-Lysine hydrochloride . L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health .

HY-B0351S1

Taurine-13C2
Taurine- ¹³C₂ is the ¹³C-labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes .

HY-B2233AS

Calcium phosphorylcholine-d9 chloride

Calcium phosphorylcholine-d₉ (chloride) is the deuterium labeled Calcium phosphorylcholine chloride. Calcium phosphorylcholine chloride is the main phospholipid component in eukaryotic biofilms. Calcium phosphorylcholine chloride exists in commensal or pathogenic bacteria associated with eukaryotes in prokaryotes. Calcium phosphorylcholine chloride exhibits a surprising range of immunomodulatory properties .

HY-144243S

Vitamin B5-d4 calcium
Vitamin B5-d₄ (calcium) is the deuterium labeled Vitamin B5 calcium .

HY-17556S1

*Folinic acid-d4 calcium* hydrate**
Folinic acid-d₄-1 (Leucovorin-d₄-1) calcium hydrate is deuterated labeled Folinic acid (HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease Methotrexate-induced toxicity.

HY-B1327S

Chlortetracycline-d6 hydrochloride
Chlortetracycline-d₆ (hydrochloride) is the deuterium labeled Chlortetracycline hydrochloride. Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is a specific and potent calcium ionophore antibiotic, inhibits binding of aminoacyl-tRNA to ribosomes.

HY-A0064S

Verapamil-d3 hydrochloride

Verapamil-d₃ (hydrochloride) is the deuterium labeled Verapamil hydrochloride. Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research .

HY-Y0785S

Glyoxal-d2
Glyoxal-d₂ is the deuterium labeled Glyoxal (HY-Y0785). Glyoxal is a cytotoxic α-oxoaldehyde. Glyoxal induces cell damage and promotes protein glycation to form advanced glycation end-products (AGEs). Glyoxal is promising for research of oxidative stress-related diseases (such as atherosclerosis, cataract, Alzheimer's disease), and the formation of calcium oxalate kidney stones .

HY-14656S

Diltiazem-d3 hydrochloride
Diltiazem-d₃ (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

HY-B0612DS1

Lercanidipine-d3 hydrochloride
Lercanidipine-d₃ (hydrochloride) is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect .

HY-N0470S2

L-Lysine-13C dihydrochloride
L-Lysine- ¹³C (dihydrochloride) is the ¹³C-labeled L-Lysine dihydrochloride. L-lysine dihydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

HY-N0470S

L-Lysine-15N2 hydrochloride
L-Lysine- ¹⁵N₂ (hydrochloride) is the ¹⁵N-labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

HY-B0405S

Bupivacaine-d9
Bupivacaine-d₉9 is a deuterium labeled Bupivacaine. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC₅₀ of 69.5 μM. Bupivacaine can be used for the research of chronic pain .

HY-12650S1

Mirogabalin-d4
Mirogabalin-d₄ (DS5565-d₄) is a deuterated compound of Mirogabalin (HY-12650), a ligand that selectively targets the voltage-sensitive calcium channel complex α2δ-1 .

HY-100807S1

Quinolinic acid-13C7
Quinolinic acid- ¹³C₇ is the ¹³C labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.

HY-W654270A

*(rac)-Calcium* N5-methyltetrahydrofolate-d3**
(rac)-Calcium N5-methyltetrahydrofolate-d₃ ((rac)-NSC173328-d₃) is a deuterium labeled (rac)-Calcium N5-methyltetrahydrofolate.

HY-B0252S3

Hydrochlorothiazide-15N2,13C,d2

Hydrochlorothiazide- ¹⁵N₂, ¹³C,d₂ is ¹⁵N and deuterated labeled Hydrochlorothiazide (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .

HY-B0347S1

Lacidipine-13C8

Lacidipine- ¹³C₈ is the deuterium labeled Lacidipine . Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .

HY-N0470S4

L-Lysine-d8 hydrochloride
L-Lysine-d₈ (hydrochloride) is the deuterium labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

HY-B0612AS

Lercanidipine-13C,d3 hydrochloride
Lercanidipine- ¹³C,d₃ (hydrochloride) is the deuterium and ¹³C labeled Lercanidipine hydrochloride . Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect .

HY-W010950S

Flecainide-d3
Flecainide-d₃ is the deuterium labeled Flecainide. Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .

HY-B0309S2

Felodipine-d3
Felodipine-d₃ is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier .

HY-W032013S1

1-Octanol-d2
1-Octanol-d₂ is the deuterium labeled 1-Octanol . 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC₅₀ of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

HY-17504S

Rosuvastatin-d6 calcium
Rosuvastatin-d₆ (calcium) is deuterium labeled Rosuvastatin.

HY-B0317AS1

Amlodipine-d9 maleate

Amlodipine-d₉ maleate is deuterated labeled Amlodipine maleate (HY-B0317A). Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer .

HY-144577S

Ortho-hydroxy atorvastatin-d5 calcium
Ortho-hydroxy atorvastatin-d₅ calcium is the deuterium labeled Ortho-hydroxy atorvastatin (HY-144577) . Ortho-hydroxy atorvastatin is the metabolic of Atorvastatin (HY-B0589) .

HY-W653912A

*Leucovorin-d4 calcium* hydrate, >90%**
Leucovorin-d₄ (Leucovorin-d₄) calcium hydrate, >90% is a deuterated labeled Folinic acid (Leucovorin, HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity .

HY-143816S

4-Hydroxy Atorvastatin-d5 hemicalcium
4-Hydroxy Atorvastatin-d₅ (calcium) is the deuterium labeled 4-Hydroxy Atorvastatin calcium .

HY-B0144S

Pitavastatin-d4 hemicalcium

Pitavastatin-d₄ (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity[1][2][3].

HY-B0317S1

Amlodipine-d4
Amlodipine-d₄ is a deuterium labeled Amlodipine (HY-B0317). Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer .

HY-B0317S

Amlodipine-1,1,2,2-d4 maleate
Amlodipine-1,1,2,2-d₄ (maleate) is the deuterium labeled Amlodipine. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer .

HY-116408AS

Propiverine-d7 hydrochloride
Propiverine-d₇ (hydrochloride) is the deuterium labeled Propiverine hydrochloride. Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence .

HY-135328AS

Norverapamil-d7 hydrochloride
Norverapamil-d₇ (hydrochloride) is a deuterium labeled Norverapamil. Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .

HY-B0265S

Nimodipine-d7
Nimodipine-d₇ is the deuterium labeled Nimodipine. Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders .

HY-N0470S5

L-Lysine-d9 hydrochloride
L-Lysine-d₉ (hydrochloride) is the deuterium labeled L-Lysine. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

HY-111613S

Pinaverium bromide-d4
Pinaverium bromide-d₄ is deuterium labeled Pinaverium bromide. Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients .

HY-17030S

Acamprosate-d3 calcium
Acamprosate-d₃ (calcium) is the deuterium labeled Acamprosate calcium. Acamprosate calcium is a GABA receptor agonist and modulator of glutamatergic systems .

HY-110233S

Acamprosate-d6 calcium
Acamprosate-d₆ (calcium) is the deuterium labeled Acamprosate calcium. Acamprosate calcium (Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems .

HY-111603S

Dobesilate-d6 calcium
Dobesilate-d₆ (calcium) is deuterium labeled Calcium dobesilate. Calcium dobesilate, a vasoprotective, is widely used in chronic venous disease, diabetic retinopathy and the symptoms of haemorrhoidal attack in many countries.

HY-17383S

Levomefolate-13C5 calcium

Levomefolate- ¹³C₅ calcium)is the ¹³C-labeled Levomefolate calcium (HY-17383). Levomefolate calcium is a synthetic calcium salt of L-5-methyltetrahydrofolate and an orally active and brain-penetrant folate supplement. Levomefolate calcium incorporates into body folate pools to increase plasma and red blood cell folate levels over time. Levomefolate calcium does not significantly increase folate concentrations in breast milk. Levomefolate calcium can be used for the research of neural tube defects and megaloblastic anemia .

HY-B0682S

Mitiglinide-d8 calcium hydrate

Mitiglinide-d₈ calcium hydrate (KAD-1229-d₈) is the deuterium labeled Mitiglinide calcium hydrate. Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes .

HY-W777434

Mitiglinide calcium hydrate-d8

Mitiglinide (calcium hydrate)-d₈ is the deuterium labeled Mitiglinide (calcium hydrate) (HY-B0682A). Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes .

HY-150532S

*(Rac)-Vitamin B5,Calcium* Salt Hydrate-13C3 15N**
(Rac)-Vitamin B5,Calcium Salt Hydrate- ¹³C₃, ¹⁵N is the ¹³C and ¹⁵N labeled (Rac)-Vitamin B5,Calcium Salt Hydrate .

Targets Recommended: Calcium Channel CaSR Calmodulin Calpain CRAC Channel PNPLA3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B2242GL

Calcium phosphate (GMP Like) Secondary Calcium (GMP Like)	Biochemical Assay Reagents	Others
Calcium phosphate (GMP Like) (Secondary calcium (GMP Like)) is the GMP Like class Calcium phosphate (HY-B2242) that can be used as pharmaceutical excipients. Calcium phosphate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-N0378AGL

D-Mannitol, M200 (GMP Like) Mannitol, M200 (GMP Like); Mannite, M200 (GMP Like)	Endogenous Metabolite Apoptosis Adrenergic Receptor PGC-1α PKA	Cardiovascular Disease Metabolic Disease Cancer
D-Mannitol, M200 (GMP Like) (Mannitol, M200 (GMP Like)) is the GMP Like class D-Mannitol that can be used as pharmaceutical excipients. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells .

HY-N0378BGL

D-Mannitol, M100 (GMP Like) Mannitol, M100 (GMP Like); Mannite, M100 (GMP Like)	Endogenous Metabolite Apoptosis Adrenergic Receptor PGC-1α PKA	Cardiovascular Disease Metabolic Disease Cancer
D-Mannitol, M100 (GMP Like) (Mannitol, M100 (GMP Like)) is the GMP Like class D-Mannitol that can be used as pharmaceutical excipients. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells .

HY-107614G

1-Oleoyl lysophosphatidic acid sodium 1-Oleoyl-sn-glycero-3-phosphate sodium; 1-Oleoyl-LPA sodium	LPL Receptor ROCK TGF-beta/Smad TGF-β Receptor	Neurological Disease Cancer
1-Oleoyl lysophosphatidic acid sodium (GMP) is the GMP-grade form of 1-Oleoyl lysophosphatidic acid sodium (HY-107614). GMP-grade small molecules serve as auxiliary reagents in cell therapy. 1-Oleoyl lysophosphatidic acid sodium is a bioactive lipid signaling molecule. 1-Oleoyl lysophosphatidic acid sodium inhibits lysoPLD-catalyzed hydrolysis of lysophosphatidylcholine and FS-3. 1-Oleoyl lysophosphatidic acid sodium activates LPA₁ and LPA₂, thereby triggering calcium mobilization, NFATc1 translocation, Rho/ROCK activation, Smad2/3 phosphorylation and c-Fos expression. 1-Oleoyl lysophosphatidic acid sodium induces anxiety-like, depression-like and hypoactivity phenotypes, regulates osteoclast cytoskeleton and viability, reduces osteoclast bone resorptive activity, and drives mesenchymal stem cell differentiation into myofibroblast-like cells. 1-Oleoyl lysophosphatidic acid sodium stimulates the secretion of transforming growth factor-β1 and stromal cell-derived factor-1. 1-Oleoyl lysophosphatidic acid sodium is applicable to research related to anxiety, depression and ovarian cancer .

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