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Results for "

LPS-stimulated

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (1) Bacterial (2) Casein Kinase (3) COX (10) Cytochrome P450 (1) Endogenous Metabolite (7) ERK (2) HDAC (1) Interleukin Related (5) Isotope-Labeled Compounds (1) JNK (2) Keap1-Nrf2 (1) MAP3K (1) Microtubule/Tubulin (1) NF-κB (14) NO Synthase (4) p38 MAPK (8) Parasite (1) PGE synthase (1) Reactive Oxygen Species (1) TNF Receptor (3)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (38) Metabolic Disease (1) Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10120

Methylsyringin

Others Inflammation/Immunology

Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells.

Methylsyringin	Others	Inflammation/Immunology
Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells.

HY-N1380

Guaiacol 2-Methoxyphenol	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation . Anti-inflammatory activity .

HY-N0358

1,4-Dicaffeoylquinic acid 1 Publications Verification 1,4-DCQA	TNF Receptor Interleukin Related	Inflammation/Immunology
1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production .

HY-N3473

Isomaculosidine	NO Synthase	Neurological Disease
Isomaculosidine is an alkaloid that can be isolated from D. dasycarpus. Isomaculosidine can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 microglial cells .

HY-N2989

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid	NO Synthase	Inflammation/Immunology
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid, an anti-inflammatory triterpenoid, inhibits NO production and iNOS expression in LPS-stimulated Raw264.7 cells .

HY-N9891

12-Dehydrogingerdione 12-DHGD	NO Synthase Interleukin Related	Inflammation/Immunology
12-Dehydrogingerdione is an inhibitor of NO Synthase. 12-Dehydrogingerdione signi?cantly inhibits LPS-stimulated production of NO, IL-6 and PGE2 in Raw 264.7 cells .

HY-N2495

Isomucronulatol	Others	Inflammation/Immunology
Isomucronulatol is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol exhibits inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

HY-N1912

Andropanolide	Others	Cancer
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

HY-N1380S1

Guaiacol-d3 2-Methoxyphenol-d₃	Isotope-Labeled Compounds COX NF-κB	Inflammation/Immunology
Guaiacol-d₃ is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity[1].

HY-N1195

Sugiol (+)-Sugiol; 10-Deoxoxanthoperol	p38 MAPK ERK JNK Interleukin Related TNF Receptor	Inflammation/Immunology
Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages .

HY-N1380R

Guaiacol (Standard) 2-Methoxyphenol (Standard)	COX Endogenous Metabolite NF-κB	Inflammation/Immunology
Guaiacol (Standard) is the analytical standard of Guaiacol. This product is intended for research and analytical applications. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation . Anti-inflammatory activity .

HY-N1380S

Guaiacol-d7 2-Methoxyphenol-d₇	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol-d₇ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S3

Guaiacol-d4 2-Methoxyphenol-d₄	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol-d₄ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S2

Guaiacol-13C6 2-Methoxyphenol-¹³C₆	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol- ¹³C₆ is the ¹³C labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S4

Guaiacol-d4-1 2-Methoxyphenol-d₄-1	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol-d₄-1 is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N12523

Chebulanin	NF-κB p38 MAPK	Inflammation/Immunology
Chebulanin, a polyphenol acid, exerts its anti-inflammatory and anti-arthritic effects via inhibiting NF-κB and MAPK activation in collagen-induced arthritis mice. Chebulanin inhibits the nuclear translocation of p38 and p65 in LPS-stimulated macrophages .

HY-N4233

Bisabolangelone	p38 MAPK	Inflammation/Immunology
Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone possesses anti-inflammatory properties, which inhibits LPS-stimulated inflammation through the blocking of NF-kappaB and MAPK pathways in macrophages. Bisabolangelone has anti-ulcer activities .

HY-N12494

Diplacol	NO Synthase	Inflammation/Immunology
Diplacol is a geranylated flavanone that can be isolated from paulownia trees (Paulownia coreana UYEKI). Diplacol has anti-inflammatory activity. Diplacol inhibits NO production in LPS-stimulated Raw264.7 cells with an IC₅₀ value of 4.53 μM .

HY-N8719

Pratol 7-Hydroxy-4'-methoxyflavone	NF-κB	Inflammation/Immunology
Pratol is a potent inhibitor of NF-κB. Pratol significantly reduces NO and prostaglandin PGE2 production without any cytotoxic in LPS-stimulated RAW 264.7 cells. Pratol reduces proinflammatory cytokines. Pratol can be used in study inflammatory diseases and cancer .

HY-N6250

Isomucronulatol 7-O-glucoside Isomucronulatol 7-O-β-glucoside	Others	Inflammation/Immunology
Isomucronulatol 7-O-glucoside is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol 7-O-glucoside exhibits weak inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

HY-W573700

Methyl everninate	Others	Others
Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model .

HY-N7422

Kauran-16,17-diol ent-Kauran-16β,17-diol	Apoptosis	Inflammation/Immunology Cancer
Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC₅₀ of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages .

HY-N4061

Hedycoronen A	Interleukin Related	Inflammation/Immunology
Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC₅₀s of 9.1 μM, 5.6 μM, and 46.0 μM. Hedycoronen A can be isolated from Hedychium coronarium .

HY-13982

JSH-23 Maximum Cited Publications 82 Publications Verification	NF-κB	Metabolic Disease Inflammation/Immunology Cancer
JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC₅₀ of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .

HY-32018

Cot inhibitor-2 2 Publications Verification	MAP3K	Cancer
Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC₅₀ of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC₅₀ of 0.3 μM .

HY-146168

Nrf2 activator-5	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator-5 (compound 1) is a potent Nrf2 activator that can attenuate H₂O₂-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglial cells. Nrf2 activator-5 exhibits antioxidant and anti-inflammatory activities .

HY-12511

SKF-86002 2 Publications Verification	p38 MAPK	Inflammation/Immunology
SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

HY-108641

SKF-86002 dihydrochloride	p38 MAPK	Inflammation/Immunology
SKF-86002 dihydrochloride is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

HY-162425

Anti-inflammatory agent 78	PGE synthase COX	Inflammation/Immunology Cancer
Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. Anti-inflammatory agent 78 has significant potency on PGE2, PGE1, COX-2 and COX-1 inhibition. Anti-inflammatory agent 78 can inhibits NO release in LPS-stimulated RAW 264.7 cell line .

HY-N2259

Curcumenol 2 Publications Verification (+)-Curcumenol	Cytochrome P450	Neurological Disease Inflammation/Immunology Cancer
Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC₅₀ of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells .

HY-146005

Tau-aggregation and neuroinflammation-IN-1	Microtubule/Tubulin	Neurological Disease Inflammation/Immunology
Tau-aggregation and neuroinflammation-IN-1 is a potent tau-aggregation and neuroinflammation inhibitor. Tau-aggregation and neuroinflammation-IN-1 exhibits remarkable inhibitory activities against AcPHF6 and full-length tau aggregation. Tau-aggregation and neuroinflammation-IN-1 has a low cytotoxicity and reduced NO release in LPS-stimulated BV2 cells. Tau-aggregation and neuroinflammation-IN-1 can reverse okadaic acid-induced memory impairment in rats .

HY-110133

JTE-607 2 Publications Verification	Interleukin Related	Inflammation/Immunology
JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC₅₀s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively . Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 .

HY-N8132

2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside	Reactive Oxygen Species	Inflammation/Immunology
2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside is a chlorophenyl glycoside found in the bulbs of Lilium brownie var. viridulum. 2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside exhibits weak inhibition of NO production in LPS-stimulated RAW 264.7 cells .

HY-132248

C5 Lenalidomide Lenalidomide 5'-amine	TNF Receptor	Inflammation/Immunology
C5 Lenalidomide (Lenalidomide 5'-amine) is a thalidomide analog and is a potent inhibitor of TNF-alpha production (IC₅₀=100 μM in LPS stimulated human PBMC) .

HY-130743

Dieugenol Bis-eugenol; Dehydrodieugenol	Parasite	Infection
Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC₅₀s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.

HY-N0589

Dehydrodiisoeugenol 1 Publications Verification	NF-κB COX Bacterial	Infection Inflammation/Immunology
Dehydrodiisoeugenol is isolated from Myristica fragrans Houtt, shows anti-inflammatory and anti-bacterial actions . Dehydrodiisoeugenol inhibits LPS- stimulated NF-κB activation and cyclooxygenase (COX)-2 gene expression in murine macrophages .

HY-115770

8-Methylsulfinyloctyl isothiocyanate	Bacterial	Inflammation/Immunology
8-Methylsulfinyloctyl isothiocyanate, an isothiocyanate, has antimicrobial activity and remarkable inhibitory activity against plant growth . 8-Methylsulfinyloctyl isothiocyanate impair COX-2 mediated inflammatory responses in LPS stimulated raw macrophages .

HY-N2149A

Tomatidine hydrochloride 5 Publications Verification	NF-κB JNK Autophagy Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling . Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans .

HY-163368

HDAC6-IN-34	HDAC	Inflammation/Immunology
HDAC6-IN-34 (compound 21) is an oral active and selective HDAC6 inhibitor with the IC₅₀ of 18 nM. HDAC6-IN-34 increases the acetylation level of tubulin without affecting histone acetylation in cutaneous T-cell lymphoma cells and inhibits TNF-α secretion in LPS (HY-D1056)-stimulated macrophage cells. HDAC6-IN-34 shows excellent anti-arthritic efficacy in rat .

HY-N0256

Hederagenin 3 Publications Verification	COX NF-κB	Cancer
Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury .

HY-108642

AMG-548	p38 MAPK Casein Kinase	Inflammation/Immunology
AMG-548, an orally active and selective p38α inhibitor (K_i=0.5 nM), shows slightly selective over p38β (K_i=36 nM) and >1000 fold selective against p38γ and p38δ. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC₅₀=3 nM) . AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε .

HY-108642B

AMG-548 dihydrochloride	p38 MAPK Casein Kinase	Inflammation/Immunology
AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (K_i=0.5 nM), shows slightly selective over p38β (K_i=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC₅₀=3 nM) . AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε .

HY-108642A

AMG-548 hydrochloride	p38 MAPK Casein Kinase	Inflammation/Immunology
AMG-548 hydrochloride, an orally active and selective p38α inhibitor (K_i=0.5 nM), shows slightly selective over p38β (K_i=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 hydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC₅₀=3 nM) . AMG-548 hydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε .

HY-W001174

2,5-Dihydroxyacetophenone	ERK NF-κB	Inflammation/Immunology
2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10120

Methylsyringin	Classification of Application Fields Simple Phenylpropanols Carthamus tinctorius L. Source classification Phenylpropanoids Plants Compositae Disease Research Fields Inflammation/Immunology	Others
Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells.

HY-N1380

Guaiacol 2-Methoxyphenol	Human Gut Microbiota Metabolites Monophenols other families Microorganisms Classification of Application Fields Source classification Phenols Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX NF-κB Endogenous Metabolite
Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation . Anti-inflammatory activity .

HY-N0358

1,4-Dicaffeoylquinic acid 1 Publications Verification 1,4-DCQA	Caprifoliaceae Classification of Application Fields Lonicera japonica Thunb. Source classification Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology	TNF Receptor Interleukin Related
1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production .

HY-N3473

Isomaculosidine	Alkaloids Dictamnus dasycarpus Turcz. Source classification Rutaceae Quinoline Alkaloids Plants	NO Synthase
Isomaculosidine is an alkaloid that can be isolated from D. dasycarpus. Isomaculosidine can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 microglial cells .

HY-N2989

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid	Other Terpenoids Classification of Application Fields Terpenoids Source classification Polyporaceae Poria cocos Plants Disease Research Fields Inflammation/Immunology	NO Synthase
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid, an anti-inflammatory triterpenoid, inhibits NO production and iNOS expression in LPS-stimulated Raw264.7 cells .

HY-N9891

12-Dehydrogingerdione 12-DHGD	Zingiber officinale Roscoe Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	NO Synthase Interleukin Related
12-Dehydrogingerdione is an inhibitor of NO Synthase. 12-Dehydrogingerdione signi?cantly inhibits LPS-stimulated production of NO, IL-6 and PGE2 in Raw 264.7 cells .

HY-N2495

Isomucronulatol	Structural Classification Classification of Application Fields Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Other Flavonoids Flavonoids other families Leguminosae Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Others
Isomucronulatol is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol exhibits inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

HY-N1912

Andropanolide	Structural Classification Natural Products Andrographis paniculata (Burm. F.) Nees Acanthaceae Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Others
Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .

HY-N1195

Sugiol (+)-Sugiol; 10-Deoxoxanthoperol	Structural Classification Cupressaceae Terpenoids Diterpenoids Calocedrus formosana (Florin) Florin Plants	p38 MAPK ERK JNK Interleukin Related TNF Receptor
Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages .

HY-N1380R

Guaiacol (Standard) 2-Methoxyphenol (Standard)	Structural Classification other families Classification of Application Fields Source classification Phenols Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX Endogenous Metabolite NF-κB
Guaiacol (Standard) is the analytical standard of Guaiacol. This product is intended for research and analytical applications. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation . Anti-inflammatory activity .

HY-N12523

Chebulanin	Structural Classification Combretaceae Source classification Phenols Polyphenols Terminalia chebula Retz. Plants	NF-κB p38 MAPK
Chebulanin, a polyphenol acid, exerts its anti-inflammatory and anti-arthritic effects via inhibiting NF-κB and MAPK activation in collagen-induced arthritis mice. Chebulanin inhibits the nuclear translocation of p38 and p65 in LPS-stimulated macrophages .

HY-N4233

Bisabolangelone	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Umbelliferae Disease Research Fields Inflammation/Immunology Echinacea angustifolia DC.	p38 MAPK
Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone possesses anti-inflammatory properties, which inhibits LPS-stimulated inflammation through the blocking of NF-kappaB and MAPK pathways in macrophages. Bisabolangelone has anti-ulcer activities .

HY-N12494

Diplacol	Structural Classification other families Source classification Paulownia coreana UYEKI Phenols Polyphenols Plants	NO Synthase
Diplacol is a geranylated flavanone that can be isolated from paulownia trees (Paulownia coreana UYEKI). Diplacol has anti-inflammatory activity. Diplacol inhibits NO production in LPS-stimulated Raw264.7 cells with an IC₅₀ value of 4.53 μM .

HY-N8719

Pratol 7-Hydroxy-4'-methoxyflavone	Structural Classification Flavonoids Flavones Leguminosae Source classification Plants Trifolium pratense Linn.	NF-κB
Pratol is a potent inhibitor of NF-κB. Pratol significantly reduces NO and prostaglandin PGE2 production without any cytotoxic in LPS-stimulated RAW 264.7 cells. Pratol reduces proinflammatory cytokines. Pratol can be used in study inflammatory diseases and cancer .

HY-N6250

Isomucronulatol 7-O-glucoside Isomucronulatol 7-O-β-glucoside	Flavonoids Monophenols other families Classification of Application Fields Leguminosae Isoflavanones Source classification Phenols Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Inflammation/Immunology	Others
Isomucronulatol 7-O-glucoside is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol 7-O-glucoside exhibits weak inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

HY-W573700

Methyl everninate	Structural Classification other families Source classification Plagiochila bifaria (Sw.) Lindenb. Phenols Plants	Others
Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model .

HY-N7422

Kauran-16,17-diol ent-Kauran-16β,17-diol	Liliaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Inflammation/Immunology Fritillaria cirrhosa	Apoptosis
Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC₅₀ of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages .

HY-N4061

Hedycoronen A	Hedychium coronarium Koen. Structural Classification Terpenoids Source classification Diterpenoids Plants Zingiberaceae	Interleukin Related
Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC₅₀s of 9.1 μM, 5.6 μM, and 46.0 μM. Hedycoronen A can be isolated from Hedychium coronarium .

HY-N2259

Curcumenol 2 Publications Verification (+)-Curcumenol	Structural Classification Neurological Disease Classification of Application Fields Terpenoids Sesquiterpenes Source classification Curcuma phaeocaulis Valeton Plants Inflammation/Immunology Disease Research Fields Zingiberaceae Cancer	Cytochrome P450
Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC₅₀ of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells .

HY-N8132

2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside	Natural Products Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields Inflammation/Immunology Lilium brownie var. viridulum	Reactive Oxygen Species
2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside is a chlorophenyl glycoside found in the bulbs of Lilium brownie var. viridulum. 2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside exhibits weak inhibition of NO production in LPS-stimulated RAW 264.7 cells .

HY-N0589

Dehydrodiisoeugenol 1 Publications Verification	Monophenols Classification of Application Fields Simple Phenylpropanols Source classification Phenols Myristicaceae Phenylpropanoids Plants Myristica fragrans Houtt. Inflammation/Immunology Disease Research Fields	NF-κB COX Bacterial
Dehydrodiisoeugenol is isolated from Myristica fragrans Houtt, shows anti-inflammatory and anti-bacterial actions . Dehydrodiisoeugenol inhibits LPS- stimulated NF-κB activation and cyclooxygenase (COX)-2 gene expression in murine macrophages .

HY-115770

8-Methylsulfinyloctyl isothiocyanate	Structural Classification Natural Products Classification of Application Fields Source classification Plants Brassicaceae Inflammation/Immunology Disease Research Fields Rorippa indica (L.) Hiern	Bacterial
8-Methylsulfinyloctyl isothiocyanate, an isothiocyanate, has antimicrobial activity and remarkable inhibitory activity against plant growth . 8-Methylsulfinyloctyl isothiocyanate impair COX-2 mediated inflammatory responses in LPS stimulated raw macrophages .

HY-N2149A

Tomatidine hydrochloride 5 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Solanum lycopersicum L. Solanaceae Plants Disease Research Fields Steroids	NF-κB JNK Autophagy Endogenous Metabolite
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling . Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans .

HY-N0256

Hederagenin 3 Publications Verification	Triterpenes Structural Classification Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	COX NF-κB
Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury .

HY-W001174

2,5-Dihydroxyacetophenone	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Inflammation/Immunology Disease Research Fields	ERK NF-κB
2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways .

Cat. No.	Product Name	Chemical Structure

HY-N1380S1

Guaiacol-d3
Guaiacol-d₃ is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity[1].

HY-N1380S

Guaiacol-d7
Guaiacol-d₇ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S3

Guaiacol-d4
Guaiacol-d₄ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S2

Guaiacol-13C6
Guaiacol- ¹³C₆ is the ¹³C labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S4

Guaiacol-d4-1
Guaiacol-d₄-1 is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

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LPS-stimulated

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