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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
NFKB1
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "NFKB1" in MCE Product Catalog:
111
111 Publications Verification
Cat. No.: HY-19696B
CAS No.: 117609-50-4
Synonyms: Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate
4
4 Cited Publications
Cat. No.: HY-N0772
CAS No.: 24699-16-9
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3 Cited Publications
Target:
Research Areas:
AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells [1].
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1
1 Cited Publications
Synonyms: Magnoflorine chloride; α-Magnoflorine chloride; Thalictrine chloride
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1
1 Cited Publications
Cat. No.: HY-P9928A
CAS No.: 1245916-14-6
Synonyms: REGN 727(anti-PCSK9); SAR 236553(anti-PCSK9)
Research Areas:
1
1 Cited Publications
Synonyms: Magnoflorine iodide; α-Magnoflorine iodide; Thalictrine iodide
1
1 Cited Publications
Cat. No.: HY-174138
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Research Areas:
NF-κB degrader 1 (Compound MD-1) is a NF-κB1 p105 subunit degrader. NF-κB degrader 1 shows anti-inflammatory activity (IC50 for inhibiting TNF-α is 2.02 μM, and for inhibiting NO is 5.40 μM). NF-κB degrader 1 induces p105 degradation dependent on the Cullin-RING ligase (CRL) SCFBTCP, suppressing NF-κB transcriptional activity. NF-κB degrader 1 is promising for research of inflammation-related diseases [1].
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Cat. No.: HY-49444
CAS No.: 793719-01-4
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EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism [1].
Cat. No.: HY-RS09254
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NFKB1 Human Pre-designed siRNA Set A contains three designed siRNAs for NFKB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-N7627
CAS No.: 117591-85-2
Cat. No.: HY-N1508
CAS No.: 78285-90-2
Cat. No.: HY-174569
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Research Areas:
Human NFKB1 mRNA encodes the human nuclear factor kappa B subunit 1 (NFKB1) protein, a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection.
Cat. No.: HY-RS09255
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Nfkb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nfkb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09256
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Nfkb1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nfkb1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-N3532
CAS No.: 163136-19-4
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Target:
Cat. No.: HY-W995241
CAS No.: 213481-12-0
Research Areas:
BPD is a COX-2 and TAK1-NF-κB inhibitor, with an IC50 of 18.5 μM for COX-2. BPD inhibits the expression of iNOS, TNF-α, IL-6 and IL-1β at the transcriptional level. BPD has anti-inflammatory activity. BPD can inhibit Carrageenan-induced paw oedema and LPS-induced septic death [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
