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Results for "

TACE

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (7) Bacterial (2) C-type Lectin-like Receptors (CTLRs) (2) Caspase (2) COX (1) Dengue Virus (2) Elastase (1) Estrogen Receptor/ERR (1) Fluorescent Dye (2) Interleukin Related (2) mAChR (1) MMP (21) NF-κB (3) p38 MAPK (4) Reference Standards (5) SARS-CoV (3) Small Interfering RNA (siRNA) (3) TNF Receptor (12)
By Research Areas:	Cancer (15) Cardiovascular Disease (1) Endocrinology (1) Infection (6) Inflammation/Immunology (14) Neurological Disease (5)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

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Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16657

TAPI-1 Maximum Cited Publications 15 Publications Verification	MMP NF-κB Apoptosis TNF Receptor	Inflammation/Immunology Cancer
TAPI-1 is a broad-spectrum MMP inhibitor and NF-κB p65 inhibitor that targets ADAM17/TACE, ADAM10 and other proteins. TAPI-1 reduces the proteolytic cleavage of membrane-bound TNF-α, decreases TNF-α levels, inhibits NF-κB pathway activation, and downregulates profibrotic markers. TAPI-1 reduces the proportion of proinflammatory immune cells, alleviates cardiac and airway fibrosis, and improves cardiac function after myocardial infarction. Meanwhile, TAPI-1 inhibits the viability, migration and invasion of esophageal squamous cell carcinoma cells, enhances the chemosensitivity of Cisplatin (HY-17394), induces apoptosis, and shows low toxicity to normal esophageal epithelial cells. TAPI-1 can be widely used in studies related to myocardial infarction-induced heart failure, severe traumatic tracheal stenosis, esophageal squamous cell carcinoma and other conditions .

HY-115670

GW280264X 5+ Cited Publications	MMP	Inflammation/Immunology Cancer
GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC₅₀s of 8.0 nM and 11.5 nM, respectively . ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells .

HY-100211

TAPI-2 5 Publications Verification TNF Protease Inhibitor 2	MMP SARS-CoV	Cancer
TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC₅₀ of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .

HY-16657A

(S,S)-TAPI-1	MMP mAChR	Neurological Disease Inflammation/Immunology Cancer
(S,S)-TAPI-1 is an isomer of TAPI-1. TAPI-1 is a *TACE* (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor .

HY-101448

TMI-1 1 Publications Verification WAY-171318	MMP Apoptosis Interleukin Related TNF Receptor Caspase	Infection Neurological Disease Inflammation/Immunology Cancer
TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC₅₀ of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions .

HY-20070

BMS-566394	TNF Receptor	Inflammation/Immunology
BMS-566394 is a selective, orally active *TACE* (ADAM17) inhibitor. BMS-566394 inhibits LPS-induced TNF-α production in whole blood. BMS-566394 selectively inhibits *TACE* activity .

HY-119307

Apratastat 4 Publications Verification TMI-005	MMP TNF Receptor	Cancer
Apratastat (TMI-005) is an orally active, non-selective and reversible *TACE/MMPs* inhibitor, can inhibit inhibit the release of TNF-α. Apratastat has the potential to overcome radiotherapy-resistance in non-small cell lung cancer (NSCLC) . Apratastat is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-19667A

BMS-561392 formate 2 Publications Verification DPC 333 formate	TNF Receptor NF-κB Apoptosis p38 MAPK	Neurological Disease Inflammation/Immunology
BMS-561392 formate (DPC 333 formate) is a selective *ADAM17(TACE*) inhibitor. BMS-561392 formate inhibits TNF-α secretion by regulating signaling pathways such as p44 MAPK and NF-κB. BMS-561392 formate also affects the survival of central nervous system-related cells including oligodendrocytes and microglia. BMS-561392 formate promotes microglial apoptosis, enlarges the injury area and exacerbates astrogliosis in a mouse spinal cord injury model. BMS-561392 formate can be used in research related to spinal cord injury and inflammatory diseases .

HY-118694

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing .

HY-N0434

Astragaloside III 2 Publications Verification	C-type Lectin-like Receptors (CTLRs) Apoptosis Dengue Virus	Infection Cancer
Astragaloside III is a triterpenoid saponin. Astragaloside III can be extracted from Astragalus root. Astragaloside III increases NKG2D and induces *TACE* phosphorylation. Astragaloside III induces Apoptosis. Astragaloside III has antiviral activity against dengue serotypes 1 and 3. Astragaloside III has anticancer activity against breast and colon cancer .

HY-P3722

Mca-PLAQAV-Dpa-RSSSR-NH2 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-B2158

Chlorotrianisene	Estrogen Receptor/ERR COX	Cardiovascular Disease Endocrinology
Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood .

HY-19667

BMS-561392 DPC 333	TNF Receptor NF-κB Apoptosis p38 MAPK	Neurological Disease Inflammation/Immunology
BMS-561392 (BMS-561392) is a selective *ADAM17(TACE*) inhibitor. BMS-561392 inhibits TNF-α secretion by regulating signaling pathways such as p44 MAPK and NF-κB. BMS-561392 also affects the survival of central nervous system-related cells including oligodendrocytes and microglia. BMS-561392 promotes microglial apoptosis, enlarges the injury area and exacerbates astrogliosis in a mouse spinal cord injury model. BMS-561392 can be used in research related to spinal cord injury and inflammatory diseases .

HY-P3722A

Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-122624

MMP13-IN-2	MMP	Inflammation/Immunology
MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor. MMP13-IN-2 exhibits excellent potency for MMP-13 (IC₅₀=0.036 nM) and selectivities (greater than 1,500-fold) over MMP-1, 3, 7, 8, 9, 14, and TACE. MMP13-IN-2 has the ability to block the release of collagen from cartilage in vitro. MMP13-IN-2 has the potential for collagenase related disease research .

HY-RS00271

ADAM17 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) MMP	Others
ADAM17 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ADAM17 Human Pre-designed siRNA Set A ADAM17 Human Pre-designed siRNA Set A

HY-115351

GW-3333	TNF Receptor MMP	Inflammation/Immunology
GW-3333 is a potent and orally active TNF-alpha-converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitor. GW-3333 inhibits tumor necrosis factor-alpha (TNF-alpha) production. GW-3333 can be used in research of arthritis .

HY-118734

IK-862	TNF Receptor	Inflammation/Immunology
IK-862 is a selective inhibitor of *TACE* .

HY-153504

TACE-IN-1	TNF Receptor	Inflammation/Immunology
TACE-IN-1 is an orally active hydantoin-based tumor necrosis factor-α converting enzyme (TACE) inhibitor. TACE-IN-1 inhibits the production of TNF-α in human whole blood. TACE-IN-1 can be prepared as a stable neutral form. TACE-IN-1 can be used in anti-inflammatory research .

HY-108647

EO 1428	p38 MAPK	Inflammation/Immunology
EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM ) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation .

HY-119307R

Apratastat (Standard) TMI-005 (Standard)	MMP TNF Receptor Reference Standards	Cancer
Apratastat (Standard) is the analytical standard of Apratastat. This product is intended for research and analytical applications. Apratastat (TMI-005) is an orally active, non-selective and reversible TACE/MMPs inhibitor, can inhibit inhibit the release of TNF-α. Apratastat has the potential to overcome radiotherapy-resistance in non-small cell lung cancer (NSCLC) . Apratastat is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-RS00273

Adam17 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) MMP	Others
Adam17 Rat Pre-designed siRNA Set A contains three designed siRNAs for Adam17 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Adam17 Rat Pre-designed siRNA Set A Adam17 Rat Pre-designed siRNA Set A

HY-RS00272

Adam17 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) MMP	Others
Adam17 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adam17 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Adam17 Mouse Pre-designed siRNA Set A Adam17 Mouse Pre-designed siRNA Set A

HY-123736

Ro 32-7315	MMP	Others
Ro 32-7315 is a TNF-α converting enzyme (TACE) inhibitor .

HY-110046

CL-82198 hydrochloride	MMP	Others
CL-82198 hydrochloride is a selective inhibitor of MMP-13. CL-82198 hydrochloride binds to the entire S1’ pocket of MMP-13, which is the basis of its selectivity against MMP-1, MMP-9, and TACE .

HY-100211A

(R)-TAPI-2 (R)-TNF Protease Inhibitor 2	SARS-CoV MMP	Cancer
(R)-TAPI-2 is the isomer of TAPI-2 (HY-100211A). TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC₅₀ of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .

HY-N0434R

Astragaloside III (Standard)	Reference Standards C-type Lectin-like Receptors (CTLRs) Apoptosis Dengue Virus	Infection Cancer
Astragaloside III (Standard) is the analytical standard of Astragaloside III (HY-N0434). This product is intended for research and analytical applications. Astragaloside III is a triterpenoid saponin. Astragaloside III can be extracted from Astragalus root. Astragaloside III increases NKG2D and induces *TACE* phosphorylation. Astragaloside III induces Apoptosis. Astragaloside III has antiviral activity against dengue serotypes 1 and 3. Astragaloside III has anticancer activity against breast and colon cancer .

HY-108647R

EO 1428 (Standard)	Reference Standards p38 MAPK	Inflammation/Immunology
EO 1428 (Standard) is the analytical standard of EO 1428 (HY-108647). This product is intended for research and analytical applications. EO 1428 is a highly specific inhibitor of p38 of the aminobenzophenone class. EO 1428 (1 μM ) markedly attenuates LPS-induced tumor necrosis factor α-converting enzyme (TACE) activity up-regulation .

HY-100211R

TAPI-2 (Standard) TNF Protease Inhibitor 2 (Standard)	MMP Reference Standards SARS-CoV	Cancer
TAPI-2 (Standard) is the analytical standard of TAPI-2 (HY-100211). This product is intended for research and analytical applications. TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .

HY-101448R

TMI-1 (Standard) WAY-171318 (Standard)	MMP Reference Standards Apoptosis Interleukin Related TNF Receptor Caspase	Infection Neurological Disease Inflammation/Immunology Cancer
TMI-1 (Standard) is the analytical standard of TMI-1 (HY-101448). This product is intended for research and analytical applications. TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC50 of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions .

HY-181647

LasB-IN-3	Bacterial Elastase	Infection
LasB-IN-3 is a protease elastase (LasB) inhibitor of Pseudomonas aeruginosa with an IC₅₀ value of 8.5 nM. LasB-IN-3 shows an IC₅₀ of 58.9 nM for the Met128Val mutant. LasB-IN-3 binds to active sites of wild-type and Met128Val mutant LasB, coordinates zinc ions, forms hydrogen bonds and CH-π interactions, and inhibits LasB proteolytic activity. LasB-IN-3 increases survival rate in LasB-induced acute lung injury mice models. LasB-IN-3 can be used for the research of Pseudomonas aeruginosa infection .

HY-180412

Solimastat BB-3644	MMP	Cancer
Solimastat (BB-3644) is a potent metalloproteinase (MMP) inhibitor that blocks constitutive and antibody-stimulated CD30 shedding from cell surfaces with an IC₅₀ of 180 nM. Solimastat enhances persistence of anti-CD30 antibody Ki-3 on cells and favors its internalization. Solimastat enhances cytotoxic activity of Ki-3.dgA towards CD30 ⁺ L540 cells. Solimastat can be used for the research of CD30 ⁺ malignancies .

Cat. No.	Product Name	Target	Research Area

HY-118694

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing .

HY-P3722

Mca-PLAQAV-Dpa-RSSSR-NH2 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-P3722A

Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-P5970

DABCYL-TNF-α-EDANS (-4 to +6) (human) TACE Substrate	Peptides	Cancer
DABCYL-TNF-α-EDANS (-4 to +6) (human) is a FRET peptide substrate of tumor necrosis factor convertase (TACE) .

Astragaloside III 2 Publications Verification	Triterpenes other families Classification of Application Fields Leguminosae Terpenoids Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Source Classification	C-type Lectin-like Receptors (CTLRs) Apoptosis Dengue Virus
Astragaloside III is a triterpenoid saponin. Astragaloside III can be extracted from Astragalus root. Astragaloside III increases NKG2D and induces *TACE* phosphorylation. Astragaloside III induces Apoptosis. Astragaloside III has antiviral activity against dengue serotypes 1 and 3. Astragaloside III has anticancer activity against breast and colon cancer .

Astragaloside III (Standard)	Triterpenes Structural Classification other families Leguminosae Terpenoids Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Source Classification	Reference Standards C-type Lectin-like Receptors (CTLRs) Apoptosis Dengue Virus
Astragaloside III (Standard) is the analytical standard of Astragaloside III (HY-N0434). This product is intended for research and analytical applications. Astragaloside III is a triterpenoid saponin. Astragaloside III can be extracted from Astragalus root. Astragaloside III increases NKG2D and induces *TACE* phosphorylation. Astragaloside III induces Apoptosis. Astragaloside III has antiviral activity against dengue serotypes 1 and 3. Astragaloside III has anticancer activity against breast and colon cancer .

Species:	Rat (1) Mouse (1)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78717

	*ADAM17/TACE* Protein, Mouse (HEK293, His)** ADAM17; TACE; CD156b	Mouse	HEK293
	The ADAM17/TACE protein cleaves TNF-α, releasing it from the membrane and activating various cell surface proteins such as JAM3, ACE2, and the p75 TNF receptor. It also triggers the Notch pathway by cleaving Notch into membrane-associated fragments. ADAM17/TACE Protein, Mouse (HEK293, His) is the recombinant mouse-derived ADAM17/TACE protein, expressed by HEK293 , with C-His labeled tag.

HY-P72815

	*ADAM17/TACE* Protein, Rat (HEK293, His)** 1 Publications Verification Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; TNF-alpha convertase; CD156b; TACE	Rat	HEK293
	ADAM17/TACE Protein, a pivotal enzyme, cleaves TNF-alpha and activates various cell-surface proteins like p75 TNF-receptor. It also mediates the cleavage of Notch, activates the Notch pathway, and contributes to hemostasis by shedding GP1BA. ADAM17/TACE further facilitates the cleavage of LAG3, IL6R, and FCGR3A, showcasing its significance in diverse cellular functions. ADAM17/TACE Protein, Rat (HEK293, His) is the recombinant rat-derived ADAM17/TACE protein, expressed by HEK293 , with C-10*His labeled tag.

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Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3) Rat (1) Mouse (3)
Application:	ICC/IF (3) IP (1) WB (3) FC (3) ELISA (2)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84440

	ADAM17 Antibody (YA4137) ADAM17; CSVP; TACE; NISBD; ADAM18; ; NISBD1	WB, ICC/IF, FC, ELISA	Human, Mouse
	ADAM17 Antibody (YA4137) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ADAM17.

HY-P84440A

	ADAM17 Antibody (YA4137)(PBS only) ADAM17; CSVP; TACE; NISBD; ADAM18; ; NISBD1	WB, ICC/IF, FC, ELISA	Human, Mouse
	ADAM17 Antibody (YA4137) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ADAM17.

HY-P81817

	ADAM17 Antibody (YA1562) CD156b; ADAM17; CSVP; TACE	WB, ICC/IF, IP, FC	Human, Mouse, Rat
	ADAM17 Antibody (YA1562) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADAM17.