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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
337 Results for "
factor D
" in MedChemExpress (MCE) Product Catalog:
Products (337)
337 Results for "factor D" in MCE Product Catalog:
144
144 Publications Verification
Target:
Mixed Lineage Kinase Necroptosis Pyroptosis Caspase NOD-like Receptor (NLR) Keap1-Nrf2 TNF Receptor Interleukin Related NO Synthase Heme Oxygenase (HO)
Áreas de investigación:
Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways .
6
6 Cited Publications
Synonyms: 4-Caffeoylquinic acid; 4-O-Caffeoylquinic acid
5
5 Cited Publications
Synonyms: ACH-4471
Target:
Áreas de investigación:
Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .
5
5
4
3
3 Cited Publications
Referencia número: HY-N2370
No. CAS: 30271-38-6
3
2
2 Cited Publications
Synonyms: ALXN2050; ACH 0145228; ACH-5228
Target:
Áreas de investigación:
Vemircopan (ALXN2050) is an orally active complement factor D (FD) inhibitor. Vemircopan can be used in the research of diseases such as myasthenia gravis, lupus nephritis, IgA nephropathy, and paroxysmal nocturnal hemoglobinuria .
2
2 Cited Publications
Referencia número: HY-K6004
MCE Growth Factor Reduced Basement Membrane Matrix (Phenol Red-Free) is primarily composed of natural basement membrane matrix extracted from mouse tumors and contains abundant extracellular matrix components and a variety of naturally occurring growth factors. This product is primarily designed for 3D organoid culture and other research applications requiring high-quality basement membrane matrix. The phenol red-free formulation avoids potential interference with experiments requiring subsequent colorimetric or color-based analysis.
2
2 Cited Publications
Referencia número: HY-K6008
MCE High-Concentration Basement Membrane Matrix (Phenol Red-Free) is primarily composed of natural basement membrane matrix extracted from mouse tumors. It is rich in extracellular matrix components and various naturally occurring growth factors, and is mainly used for the establishment of animal models and 3D tumor models.
2
2 Cited Publications
Referencia número: HY-P80900
Synonyms: SREBF1; BHLHD1; SREBP1; Sterol regulatory element-binding protein 1; SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1
1
1 Cited Publications
Referencia número: HY-P4245
No. CAS: 88546-74-1
Target:
Áreas de investigación:
1
1
1 Cited Publications
Referencia número: HY-N4253
No. CAS: 173792-61-5
1
1 Cited Publications
Referencia número: HY-W014049
No. CAS: 66036-77-9
Target:
Áreas de investigación:
1
1 Cited Publications
Referencia número: HY-B0167S
No. CAS: 285979-87-5
Synonyms: 2-Hydroxybenzoic acid-d6
1
1 Cited Publications
Referencia número: HY-K6005
MCE Basement Membrane Matrix HC (High Concentration, Phenol Red) is primarily composed of natural basement membrane matrix extracted from mouse tumorsand contains abundant extracellular matrix components and a variety of naturally occurring growth factors. This product is mainly used for angiogenesis experiments, construction of animal models and 3D tumor models.
1
1 Cited Publications
Referencia número: HY-B0579S
Synonyms: Cyclosporine A-d4; Ciclosporin A-d4; CsA-d4
1
1 Cited Publications
Referencia número: HY-B2246S
No. CAS: 2687961-04-0
Synonyms: (R)-Carnitine-d9 chloride; Levocarnitine-d9 chloride
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
