Search Result

Results for "

mGluR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	mGluR (208) Akt (5) Aminopeptidase (2) Amyloid-β (4) Apoptosis (4) Autophagy (1) Bacterial (1) Bcl-2 Family (1) Calcium Channel (5) CaMK (1) Carboxypeptidase (1) Caspase (2) CaSR (1) Endogenous Metabolite (9) ERK (5) GABA Receptor (3) iGluR (6) Isotope-Labeled Compounds (2) Mitochondrial Metabolism (1) mTOR (1) Na+/Ca2+ Exchanger (1) nAChR (2) NF-κB (3) Phosphatase (1) PI3K (1) PKC (3) Reference Standards (33) Small Interfering RNA (siRNA) (1) Src (1) Steroid Sulfatase (1) Tau Protein (1) Trk Receptor (3)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (6) Metabolic Disease (3) Neurological Disease (198)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) siRNAs (1)

218

Inhibitors & Agonists

Screening Libraries

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Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: mGluR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12598A

DHPG 4 Publications Verification (RS)-3,5-DHPG	mGluR	Neurological Disease
DHPG is the agonist for mGluR 1/5 (EC₅₀ for mGluR 1 is 60 nM) that activates the phospholipase C (PLC) pathway, and leads ultimately to the activation of protein kinase C (PKC) .

HY-15129

O-Phospho-L-serine 3 Publications Verification L-Serine O-phosphate; L-SOP	mGluR Endogenous Metabolite	Neurological Disease
O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the *group III mGluR* receptors** (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for *mGluR1* and a potent antagonist for *mGluR2* .

HY-12598

(S)-3,5-DHPG	mGluR	Neurological Disease
(S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with K_i values of 0.9 μM and 3.9 μM for mGluR1a and mGluR5a, respectively . (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia .

HY-50906

LY404039 2 Publications Verification	mGluR	Neurological Disease
LY404039 is a potent, selective and orally active *mGluR2* and *mGluR3* agonist with K_is of 149 nM and 92 nM for recombinant human mGluR2 and *mGluR3, respectively. LY404039 shows >100-fold selectivity for mGluR*2/3 over other receptors/transproters. LY404039 has antipsychotic and anxiolytic effects .

HY-15445

CTEP 2 Publications Verification RO 4956371; mGluR5 inhibitor	mGluR	Neurological Disease
CTEP (RO 4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC₅₀ of 2.2 nM, and shows > 1000-fold selectivity over other mGlu receptors. CTEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-12597

Quisqualic acid L-Quisqualic acid	iGluR mGluR	Neurological Disease
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and *mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀* of 45 nM and a K_i of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica .

HY-100804

L-Cysteinesulfinic acid 2 Publications Verification	mGluR Endogenous Metabolite	Neurological Disease
L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-100786

DL-AP3 1 Publications Verification	Endogenous Metabolite mGluR Phosphatase	Neurological Disease Cancer
DL-AP3 is a competitive *mGluR1* and *mGluR5* antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect .

HY-103111

MMPIP hydrochloride	mGluR	Neurological Disease
MMPIP hydrochloride is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (K_B values 24 -30 nM). MMPIP hydrochloride acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice .

HY-107481

Fasoracetam NS 105	mGluR	Neurological Disease
Fasoracetam (NS 105) is the activator of metabotropic glutamate receptor (mGluR). Fasoracetam (NS 105) has the potential for the research of attention-deficit hyperactivity disorder (ADHD) and Alzheimer's disease (AD) .

HY-W017230

L-Cysteinesulfinic acid monohydrate 2 Publications Verification	mGluR Endogenous Metabolite	Neurological Disease
L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-110190

VU0422288 ML396	mGluR	Neurological Disease
VU0422288 (ML396) is a positive allosteric modulator of group III *mGluRs. VU0422288 inhibits mGluRs* with EC₅₀s of 125 nM, 146 nM, and 108 nM for *mGluR4, mGluR7, and mGluR8*, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice .

HY-18654

ADX88178 1 Publications Verification	mGluR	Neurological Disease
ADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC₅₀ of 4 nM for human mGluR4.

HY-100406

(S)-MCPG 1 Publications Verification (+)-MCPG	mGluR	Neurological Disease
(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371) . (S)-MCPG can be used for the study of the function of mGluRs in spatial learning .

HY-103565

AMN082 1 Publications Verification	mGluR	Neurological Disease
AMN082, a selective, orally active, and brain penetrant *mGluR7* agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC₅₀ values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects .

HY-107457

AZD-8529 1 Publications Verification	mGluR	Neurological Disease
AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of *mGluR2, with an EC₅₀* of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.

HY-122559

BMS-984923	mGluR	Neurological Disease
BMS-984923, a potent *mGluR5* silent allosteric modulator (SAM), with exquisite binding affinity (K_i = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling .

HY-122255

LY487379	mGluR	Neurological Disease
LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [ ³⁵S]GTPγS binding with EC₅₀ values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research .

HY-14612

CPPHA	mGluR	Neurological Disease
CPPHA is potent and selective positive allosteric modulator (PAM) of the *mGluR5* and *mGluR1* (metabotropic glutamate receptor). CPPHA can potentiate responses of mGluR5 and mGluR1 to activation of these receptors. CPPHA is developed for the research of central nervous system disorders .

HY-16766

Decoglurant RO4995819	mGluR	Neurological Disease
Decoglurant (RO4995819) is a negative allosteric modulator of *mGluR2* and *mGluR3*. Decoglurant is developed as an antidepressant .

HY-100405

FTIDC	mGluR	Neurological Disease
FTIDC is an orally active, noncompetitive, selective allosteric *metabotropic glutamate receptor (mGluR) 1* antagonist with an IC₅₀ of 5.8 nM for human mGluR1a. FTIDC has no species differences in its antagonistic activity on recombinant human, mouse, and rat mGluR1 .

HY-153615

CVN636	mGluR	Neurological Disease
CVN636 is a potent, orally active and selective *mGluR7* allosteric agonist with an EC₅₀ value of 7 nM for hu mGluR7. CVN636 has central nervous system (CNS) permeability .

HY-107516

(S)-3,4-DCPG (S)-3,4-Dicarboxyphenylglycine	mGluR	Neurological Disease
(S)-3,4-DCPG is a selective agonist of metabotropic glutamate receptor 8a (mGluR8a) with an EC₅₀ of 31 nM in AV12-664 cells expressing human mGluR8 .

HY-14418

VU0361737 ML-128	mGluR	Neurological Disease
VU0361737 (ML-128) is a potent, selective and CNS penetrant positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR₄ PAM), with EC₅₀s of 240 nM and 110 nM for human and rat mGluR₄ receptors, respectively. VU0361737 has neuroprotective effect. VU0361737 is potential for Parkinson's disease research .

HY-101332

EGLU 1 Publications Verification (2S)-α-Ethylglutamic acid; (2S)-α-EGLU	mGluR	Neurological Disease
EGLU ((2S)-α-Ethylglutamic acid; (2S)-α-EGLU) is a potent and competitive *mGluR-2* receptor antagonist. EGLU interacts with (lS,3S)-ACPD-sensitive site with a K_d value of 66 μM. EGLU is an antidepressant agent .

HY-110122

AZ 12216052 1 Publications Verification	mGluR	Neurological Disease
AZ 12216052 is a *mGluR8* positive allosteric modulator, and helps *mGluR8* modulate signaling inputing to retinal ganglion cells. AZ 12216052 exhibits antianxiety effect .

HY-14417

VU0155041	mGluR	Neurological Disease
VU0155041 is a potent, selective positive allosteric modulator (PAM) of *mGluR4, with EC₅₀s of 798 nM and 693 nM for human and rat mGluR*4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD) .

HY-107503

MMPIP	mGluR	Neurological Disease
MMPIP is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (K_B values 24 -30 nM). MMPIP acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP alleviates pain and normalizes affective and cognitive behavior in neuropathic mice .

HY-121848

VU0155094 ML397	mGluR	Neurological Disease
VU0155094 is a positive allosteric modulator with differential activity at the various group III mGluRs .

HY-155352

mGluR5 antagonist-1	mGluR	Neurological Disease
mGluR5 antagonist-1 is an orally active *mGluR5* antagonist with an IC₅₀ value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect. mGluR5 antagonist-1 can be used for the study of depressive disorder .

HY-130630

mGluR2 modulator 1	mGluR	Neurological Disease
mGluR2 modulator 1 (compound 95) is a potent and BBB-penetrated *mGluR2* (metabotropic glutamate receptor-2) positive allosteric modulator, with an EC₅₀ of 0.03 μM. mGluR2 modulator 1 can be used for psychosis research .

HY-108546

L-AP3 3-Phosphono-L-alanine	mGluR	Neurological Disease
L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC₅₀s of 368 μM and 2087 μM, respectively .

HY-15129S

O-Phospho-L-serine-13C3,15N L-Serine O-phosphate-¹³C₃,¹⁵N; L-SOP-¹³C₃,¹⁵N	mGluR Endogenous Metabolite	Neurological Disease
O-Phospho-L-serine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .

HY-15129R

O-Phospho-L-serine (Standard) L-Serine O-phosphate (Standard); L-SOP (Standard)	Reference Standards mGluR Endogenous Metabolite	Neurological Disease
O-Phospho-L-serine (Standard) (L-Serine O-phosphate (Standard)) is the analytical standard of O-Phospho-L-serine (HY-15129). This product is intended for research and analytical applications. O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8). O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.

HY-103564

ACDPP	mGluR	Neurological Disease
ACDPP is a specific *mGluR5* antagonist. ACDPP partially bolcks the increase of fragile X mental retardation protein (FMRP) caused by DHPG (HY-12598A) (group I mGluR Agonist) .

HY-100382

FPTQ	mGluR	Others
FPTQ is potent *mGluR₁* antagonist with IC₅₀ values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively . FPTQ has anti-oxidant and anti-inflammatory effects in vitro and in vivo .

HY-107457A

AZD-8529 mesylate 1 Publications Verification	mGluR	Neurological Disease
AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of *mGluR2, with an EC₅₀* of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes .

HY-153132

mGluR3 modulator-1	mGluR	Metabolic Disease
mGluR3 modulator-1 (compound 3) is a *mGluR3* modulator, with an EC₅₀ of 1-10 μM in HEK293T-mGluR-Gqi5 Calcium Mobilization Assay .

HY-133555

mGluR2 antagonist 1	mGluR	Neurological Disease
mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of *mGluR2* negative allosteric modulator (IC₅₀ of 9 nM) with excellent brain permeability .

HY-123411

MGS0039 BCI 632	mGluR	Neurological Disease
MGS0039 is a type II group *mGluR* antagonist. MGS0039 has a high affinity for mGluR2 and mGluR3, with K_i values of 2.2 nM and 4.5 nM, respectively. MGS0039 can attenuate the inhibitory effect of glutamate-induced cyclic AMP formation triggered by Forskolin (HY-15371) in CHO cells expressing mGluR2/mGluR3. MGS0039 shows antidepressant-like activity in rats .

HY-103572

MNI137	mGluR	Neurological Disease
MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC₅₀s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization .

HY-W017230R

L-Cysteinesulfinic acid monohydrate (Standard)	Reference Standards mGluR Endogenous Metabolite	Neurological Disease
L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-100804R

L-Cysteinesulfinic acid (Standard)	Reference Standards mGluR Endogenous Metabolite	Neurological Disease
L-Cysteinesulfinic acid (Standard) is the analytical standard of L-Cysteinesulfinic acid. This product is intended for research and analytical applications. L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-119282

AZD6538	mGluR	Neurological Disease
AZD6538 is a potent, selective and brain penetrant mGluR5 negative allosteric modulator. AZD6538 inhibits DHPG (HY-12598A)-stimulated intracellular Ca2+ release in HEK cells expressing rat or human mGluR5, with IC₅₀ values of 3.2 and 13.4 nM for rat mGluR5 and human mGluR5, respectively. AZD6538 can be used for the research of neuropathic pain .

HY-107507

Ro 01-6128 1 Publications Verification	mGluR	Neurological Disease
Ro 01-6128 is a positive allosteric modulator of *mGluR1* .

HY-103574

Raseglurant hydrochloride ADX-10059 hydrochloride	mGluR	Neurological Disease
Raseglurant hydrochloride is a negative allosteric modulator of *mGluR5*. Raseglurant hydrochloride can be used in study migraine .

HY-100372

E4CPG (RS)-ECPG	mGluR	Neurological Disease
E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation .

HY-162232

mGluR2 agonist 1	mGluR	Neurological Disease
mGluR2 agonist 1 (Compound 5b) is a potent and selective metabotropic glutamate 2 receptor (mGluR) agonist with an EC₅₀ of 82 nM. mGluR2 agonist 1 can be used for the research of central nervous system (CNS) diseases .

HY-162232A

mGluR2 agonist 1 hydrochloride	mGluR	Neurological Disease
mGluR2 agonist 1 hydrochloride is a potent selective agonist for metabotropic glutamate receptors mGluR 2 with EC₅₀ of 82 nM .

HY-103561

DCB	mGluR	Neurological Disease
DCB (3,3′-dichlorobenzaldazine) is an neutral allosteric modulator of themetabotropic glutamate receptor metabotropic glutamate receptor subtype 5 (mGluR5) . DCB blocks the positive allosteric regulation of mGluRs (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB). DCB shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB) .

Cat. No.	Product Name

HY-L006

GPCR/G Protein Compound Library

3,389 compounds

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. GPCRs play an important role in the human body, and increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third to one-half of all approved drugs act by binding to GPCRs. GPCRs are a large group of drug targets in drug discovery.

MCE provides a unique collection of 3,389 small molecules targeting GPCRs that can be used in the screening for various GPCRs-related research and drug development projects.

Cat. No.	Product Name	Target	Research Area

HY-P1363

β-Amyloid (1-42), human TFA Maximum Cited Publications 24 Publications Verification Amyloid β-peptide (1-42) (human) TFA	Amyloid-β	Neurological Disease
β-Amyloid (1-42) (Amyloid β-peptide (1-42), human TFA, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human TFA remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human TFA, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-P1363A

β-Amyloid (1-42), human Maximum Cited Publications 24 Publications Verification Amyloid β-peptide (1-42) (human)	Amyloid-β	Neurological Disease
β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-P1363B

β-Amyloid (1-42), human, HFIP-treated Maximum Cited Publications 24 Publications Verification	Amyloid-β	Neurological Disease
β-Amyloid (1-42), human, HFIP-treated, a 42-amino acid peptide that has been treated with HFIP from β-Amyloid (1-42), human (HY-P1363A), is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human, HFIP-treated remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, HFIP-treated, after being dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4°C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37°C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-P1363S1

β-Amyloid (1-42), human, Ala(13C3,15N) TFA	Isotope-Labeled Compounds Amyloid-β	Neurological Disease
β-Amyloid (1-42), human, Ala( ¹³C₃, ¹⁵N) TFA is the ¹³C and ¹⁵N-labeled β-Amyloid (1-42), human (HY-P1363A). β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W015546

β-N-methylamino-L-alanine hydrochloride 2 Publications Verification BMAA hydrochloride	Structural Classification Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Bacterial mGluR PKC
β-N-methylamino-L-alanine hydrochloride (BMAA hydrochloride) is a neurotoxin produced by cyanobacteria. β-N-methylamino-L-alanine hydrochloride activates *mGluR3* and inhibits PKC. β-N-methylamino-L-alanine hydrochloride can be used in the research of neurodegenerative diseases and immune diseases .

HY-15129

O-Phospho-L-serine 3 Publications Verification L-Serine O-phosphate; L-SOP	Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Source Classification	mGluR Endogenous Metabolite
O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the *group III mGluR* receptors** (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for *mGluR1* and a potent antagonist for *mGluR2* .

HY-12597

Quisqualic acid L-Quisqualic acid	Ketones, Aldehydes, Acids Combretaceae Plants Quisqualis indica Linn. Source Classification	iGluR mGluR
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and *mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀* of 45 nM and a K_i of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica .

HY-100804

L-Cysteinesulfinic acid 2 Publications Verification	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	mGluR Endogenous Metabolite
L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-100786

DL-AP3 1 Publications Verification	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite mGluR Phosphatase
DL-AP3 is a competitive *mGluR1* and *mGluR5* antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect .

HY-W017230

L-Cysteinesulfinic acid monohydrate 2 Publications Verification	Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	mGluR Endogenous Metabolite
L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-W017230R

L-Cysteinesulfinic acid monohydrate (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards mGluR Endogenous Metabolite
L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-100804R

L-Cysteinesulfinic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards mGluR Endogenous Metabolite
L-Cysteinesulfinic acid (Standard) is the analytical standard of L-Cysteinesulfinic acid. This product is intended for research and analytical applications. L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

Species:	Human (3)
Tag:	His (3) Flag (1)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703140

	GRM2 Protein, Human (sf9, His) GPRC1B; mGluR2	Human	Sf9 insect cells
	GRM2 Protein, Human (sf9, His) is the recombinant human-derived GRM2, expressed by sf9 insect cells , with His labeled tag.

HY-P703139

	GRM1 Protein, Human (sf9, Flag, His) GPRC1A; mGluR1	Human	Sf9 insect cells
	GRM1 Protein, Human (sf9, Flag, His) is the recombinant human-derived GRM1, expressed by sf9 insect cells , with His, Flag labeled tag.

HY-P701627

	GRM5 Protein, Human (sf9, His) GRM5; Metabotropic glutamate receptor 5; mGluR5	Human	Sf9 insect cells
	The GRM5 protein is a G protein-coupled glutamate receptor that undergoes ligand-induced conformational changes and activates signaling cascades through G proteins, affecting downstream effectors. This cascade includes the phosphatidylinositol-calcium second messenger system and induces calcium-activated chloride currents. GRM5 Protein, Human (sf9, His) is the recombinant human-derived GRM5 protein, expressed by sf9 insect cells , with C-10*His labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-15129S

O-Phospho-L-serine-13C3,15N
O-Phospho-L-serine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .

HY-P1363S1

β-Amyloid (1-42), human, Ala(13C3,15N) TFA

β-Amyloid (1-42), human, Ala( ¹³C₃, ¹⁵N) TFA is the ¹³C and ¹⁵N-labeled β-Amyloid (1-42), human (HY-P1363A). β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-W751156

O-Phospho-L-serine-13C3

O-Phospho-L-serine- ¹³C₃ (L-Serine O-phosphate- ¹³C₃) is the ¹³C-labeled O-Phospho-L-serine (HY-15129). O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2 .

Host:	Mouse (12) Rabbit (6)
Reactivity:	Human (18) Rat (6) Mouse (8)
Application:	IHC-P (10) ICC/IF (8) IP (1) WB (10) FC (10) ELISA (10)
Isotype:	IgG (6) IgG1 (8) IgG2a (4)
Conjugation:	Non-conjugated (18)
Clonality:	Monoclonal (9) Monoclonal Antibody (2) Recombinant (5)
Modification:	Unmodified (11)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83450

	mGluR1 Antibody (YA3195) GRM1; GPRC1A; mGluR1; Metabotropic glutamate receptor 1; mGluR1	WB	Human, Mouse, Rat
	mGluR1 Antibody (YA3195) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to mGluR1.

HY-P83473

	Metabotropic Glutamate Receptor 2 Antibody (YA3218) GRM2; GPRC1B; mGluR2; Metabotropic glutamate receptor 2; mGluR2; GRM3; GPRC1C; mGluR3; Metabotropic glutamate receptor 3; mGluR3	WB, IHC-P	Human, Mouse
	Metabotropic Glutamate Receptor 2 Antibody (YA3218) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Metabotropic Glutamate Receptor 2.

HY-P83473A

	Metabotropic Glutamate Receptor 2 Antibody (YA3218)(PBS only) GRM2; GPRC1B; mGluR2; Metabotropic glutamate receptor 2; mGluR2; GRM3; GPRC1C; mGluR3; Metabotropic glutamate receptor 3; mGluR3	WB, IHC-P	Human, Mouse
	Metabotropic Glutamate Receptor 2 Antibody (YA3218) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Metabotropic Glutamate Receptor 2.

HY-P88120

	GRM4 Antibody (YA7804) GPRC1D; mGlu4; mGluR4	IHC-P	Human, Mouse, Rat
	GRM4 Antibody (YA7804) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GRM4.

HY-P83787

	GRM8 Antibody (YA3484) GLUR8; mGlu8; GPRC1H; mGluR8	WB, FC, ELISA	Human
	GRM8 Antibody (YA3484) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GRM8.

HY-P88120A

	GRM4 Antibody (YA7804)(PBS only) GPRC1D; mGlu4; mGluR4	IHC-P	Human, Mouse, Rat
	GRM4 Antibody (YA7804) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GRM4.

HY-P83787A

	GRM8 Antibody (YA3484)(PBS only) GLUR8; mGlu8; GPRC1H; mGluR8	WB, FC, ELISA	Human
	GRM8 Antibody (YA3484) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GRM8.

HY-P84578

	Metabotropic Glutamate Receptor 3 Antibody (YA4275) GLUR3; mGlu3; GPRC1C; mGluR3	IHC-P, ICC/IF, FC, ELISA	Human
	Metabotropic Glutamate Receptor 3 Antibody (YA4275) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Metabotropic Glutamate Receptor 3.

HY-P84569

	Metabotropic Glutamate Receptor 2 Antibody (YA4266) GLUR2; mGlu2; GPRC1B; mGluR2	WB, FC, ELISA	Human
	Metabotropic Glutamate Receptor 2 Antibody (YA4266) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic Glutamate Receptor 2.

HY-P84577

	GRM7 Antibody (YA4274) GLUR7; MGLU7; GPRC1G; mGluR7; PPP1R87	ICC/IF, FC, ELISA	Human
	GRM7 Antibody (YA4274) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GRM7.

HY-P83232

	Metabotropic Glutamate Receptor 3 Antibody (YA2977) GLUR3; GPRC1C; GRM3; MGlu3; mGluR3	WB	Human, Mouse, Rat
	Metabotropic Glutamate Receptor 3 Antibody (YA2977) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Metabotropic Glutamate Receptor 3.

HY-P84310

	Metabotropic glutamate receptor 5 Antibody (YA4007) mGlu5; GPRC1E; mGluR5; PPP1R86	IHC-P, ICC/IF, ELISA	Human
	Metabotropic glutamate receptor 5 Antibody (YA4007) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic glutamate receptor 5.

HY-P84569A

	Metabotropic Glutamate Receptor 2 Antibody (YA4266)(PBS only) GLUR2; mGlu2; GPRC1B; mGluR2	WB, FC, ELISA	Human
	Metabotropic Glutamate Receptor 2 Antibody (YA4266) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic Glutamate Receptor 2.

HY-P84577A

	GRM7 Antibody (YA4274)(PBS only) GLUR7; MGLU7; GPRC1G; mGluR7; PPP1R87	ICC/IF, FC, ELISA	Human
	GRM7 Antibody (YA4274) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GRM7.

HY-P84578A

	Metabotropic Glutamate Receptor 3 Antibody (YA4275)(PBS only) GLUR3; mGlu3; GPRC1C; mGluR3	IHC-P, ICC/IF, FC, ELISA	Human
	Metabotropic Glutamate Receptor 3 Antibody (YA4275) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Metabotropic Glutamate Receptor 3.

HY-P84310A

	Metabotropic glutamate receptor 5 Antibody (YA4007)(PBS only) mGlu5; GPRC1E; mGluR5; PPP1R86	IHC-P, ICC/IF, ELISA	Human
	Metabotropic glutamate receptor 5 Antibody (YA4007) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic glutamate receptor 5.

HY-P80220

	Metabotropic glutamate receptor 5 Antibody (YA297) GPRC1E; GRM5; Metabotropic Glutamate Receptor 5 precursor; mGluR5; MGR5	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat
	Metabotropic glutamate receptor 5 Antibody (YA297) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Metabotropic glutamate receptor 5.

HY-P81764

	Metabotropic glutamate receptor 5 Antibody (YA1509) GPRC1E; GRM5; Metabotropic glutamate receptor 5 precursor; mGluR5; MGR5	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Metabotropic glutamate receptor 5 Antibody (YA1509) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Metabotropic glutamate receptor 5.