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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
130 Results for "
non-heme Fe(II)-dependent oxygenase
" in MedChemExpress (MCE) Product Catalog:
Products (130)
130 Results for "non-heme Fe(II)-dependent oxygenase" in MCE Product Catalog:
94
Target:
71
71 Cited Publications
Synonyms: Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9
24
24 Cited Publications
Synonyms: Tin-protoporphyrin IX; Sn-Protoporphyrin; SnPPIX
Target:
Research Areas:
Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model .
17
17
17 Cited Publications
Research Areas:
YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors .
17
17 Cited Publications
Research Areas:
YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors .
16
16
16 Cited Publications
Synonyms: Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt
16
Target:
Research Areas:
IOX1, a chemical probe, is a potent broad‐spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 inhibits KDM4C, KDM4E, KDM2A, KDM3A and KDM6B with IC50 values of 0.6 μM, 2.3 μM, 1.8 μM, 0.1 μM and 1.4 μM, respectively . IOX1 also inhibits ALKBH5 .
12
12 Cited Publications
Target:
Research Areas:
Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 0.25 μM .
12
12 Cited Publications
Target:
Research Areas:
Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research .
5
5 Cited Publications
Synonyms: 11-Deoxycortisol; cortexolone; Reichstein's substance S
4
Category:
Monophenols Umbelliferae Extract Simple Phenylpropanols Phenols Dicerothamnus rhinocerotis Phenylpropanoids Plants
Target:
4
Category:
Cardiovascular Disease Flavonols Flavonoids Phenols Polyphenols Plants Other Families Extract Disease Research Fields
Target:
3
3 Cited Publications
Target:
Research Areas:
DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia .
3
3
3 Cited Publications
Synonyms: Oxyberberin; Berlambine; 8-Oxoberberine
Category:
Infection Rutaceae Extract Alkaloids Phellodendron amurense Rupr. Plants Disease Research Fields Isoquinoline Alkaloids
Target:
2
2 Cited Publications
Cat. No.: HY-B2184
CAS No.: 64506-49-6
Research Areas:
Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
2
Target:
Research Areas:
Decyl maltose neopentyl glycol (DMNG) is the neopentyl glycol detergent that does not disrupt the AlkB oligomeric state. AlkB is a nonheme di-iron alkane hydroxylase .
1
1 Cited Publications
Research Areas:
Hydronidone is an orally active pyridine derivative. Hydronidone is an inhibitor of phosphodiesterase-4 (PDE4) and cyclo-oxygenase (COX) as well as TGF-β. Hydronidone induces mitochondrial dysfunction and triggers apoptosis. Hydronidone can be used for liver fibrosis, anti-inflammation and anti-cancer study .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
