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Results for "

oleanane

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (4) Bacterial (1) Bcl-2 Family (1) Biochemical Assay Reagents (3) CDK (2) DNA/RNA Synthesis (1) Drug Derivative (7) ERK (2) Fungal (2) HSV (1) JNK (2) Keap1-Nrf2 (1) mTOR (2) NF-κB (1) NO Synthase (1) PI3K (2) Reference Standards (1) VEGFR (2) Wee1 (2) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (11) Cardiovascular Disease (4) Infection (3) Inflammation/Immunology (6) Metabolic Disease (5) Neurological Disease (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112671

CDDO-dhTFEA RTA dh404	Keap1-Nrf2 NF-κB Apoptosis	Cardiovascular Disease Inflammation/Immunology
CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB . CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats .

HY-N0819

Raddeanin A 1 Publications Verification	Apoptosis PI3K Akt ERK mTOR Wnt β-catenin Wee1 JNK VEGFR CDK	Neurological Disease Inflammation/Immunology Cancer
Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, Wnt/β-catenin, Wee1, PI3K/AKT signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma .

HY-N7026

Celosin I 1 Publications Verification	Others	Metabolic Disease
Celosin I, an oleanane-type triterpenoid saponin isolated from the seeds of Celosia argentea L, could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibits significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice .

HY-N8156

Soyasapogenol C	HSV	Infection
Soyasapogenol C is an oleanane-type triterpenoid. Soyasapogenol C exhibits anti-HSV-1 activity, with an IC₅₀ of 18.9 μM .

HY-113767

Momordin II	DNA/RNA Synthesis	Metabolic Disease
Momordin II, an oleanane-type triterpene glycoside, is a ribosome inactivating protein. Momordin II inhibits cell-free protein synthesis, releases adenine from rat liver ribosomes and from DNA, and has no RNase activity .

HY-N7273

Soyasaponin III	Apoptosis	Cancer
Soyasaponin III, a monodesmodic oleanane triterpenoid, is one of the main potentially bioactive saponins found in soy (Glycine max) and related products. Soyasaponin III can induce apoptosis in Hep-G2 cells .

HY-N8609

Uralsaponin C	Others	Others
Uralsaponin C is an analogue of oleanane-type triterpenoid saponin. Uralsaponin C can be isolated from the roots of Glycyrrhiza uralensis Fisch .

HY-N11068

Huzhangoside C	Others	Others
Huzhangoside C is a oleanane-type triterpenoid saponin that can be isolated from the roots of Clematis argentilucida .

HY-N13847

Uralsaponin B	Bacterial	Inflammation/Immunology
Uralsaponin B is classified as an oleanane-type triterpenoid saponin. Uralsaponin B exhibits potential anti-inflammatory and anti-infective activities.

HY-N9328

Tarasaponin IV	Others	Cancer
Tarasaponin IV, as an oleanane-type triterpene saponin, is isolated from the bark of Aralia elata. Tarasaponin IV can be used for the research of cancer .

HY-N12584

Pulchinenoside E4	Others	Others
Pulchinenoside E4 (compound 2) is an oleanane-type triterpenoidal saponin that can be found in the roots ofPulsatilla chinensis . Pulchinenoside E4 shows cytotoxic activity .

HY-N9345

*(2α,3β)-Olean-12-ene-2,3-diol*	Others	Others
(2α,3β)-Olean-12-ene-2,3-diol (Compound 3) is a triterpenoid with lupane, oleanane, and ursane skeleton .

HY-N11034

24-Hydroxy-licorice-saponin A3	Others	Others
24-Hydroxy-licorice-saponin A3 is an oleanane-type triterpene saponin (OTS). 24-Hydroxy-licorice-saponin A3 can be isolated from G. uralensis. .

HY-N3523

3-O-Beta-D-Glucopyranosylplatycodigenin	Others	Cancer
3-O-Beta-D-Glucopyranosylplatycodigenin is an oleanane-type triterpenoid isolated from roots of Platycodon grandiflorum. 3-O-Beta-D-Glucopyranosylplatycodigenin exhibits anti-proliferative activities against HSC-T6 cell line with an IC₅₀ of 13.36 μM .

HY-N13115A

Protoescigenin 21-tiglate (E)-21-Angeloyl-protoaescigenin	Others	Cancer
Protoescigenin 21-tiglate (compound 10) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. However, the antitumor activity of Protoescigenin 21-tiglate is relatively weak, with IC50 values of >80 μM and 80 μM against MCF-7 and HeLa cells, respectively .

HY-N13115

21-Angeloyl-protoaescigenin (Z)-Protoescigenin 21-tiglate	Others	Cancer
21-Angeloyl-protoaescigenin (compound 11) is a glycosidic oleanane-type triterpenoid (BAT) that can be isolated from the acid hydrolysis product (AHP) of the crude extract of Aesculus chinensis seeds. Aesculus-derived triterpenoids (BAT) generally exhibit good antitumor, anti-inflammatory, and anti-Alzheimer's activities. Protoescigenin 21-tiglate has antitumor activity, with IC50 values of 38.2 μM and 33 μM against MCF-7 and HeLa cells, respectively .

HY-N0819R

Raddeanin A (Standard)	Reference Standards Apoptosis PI3K Akt ERK mTOR Wnt β-catenin Wee1 JNK VEGFR CDK	Neurological Disease Inflammation/Immunology Cancer
Raddeanin A (Standard) is the analytical standard of Raddeanin A (HY-N0819). This product is intended for research and analytical applications. Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, Wnt/β-catenin, Wee1, PI3K/AKT signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma.

HY-N1256

Sculponeatic acid	Others	Others
Sculponeatic acid is a new A-ring contracted oleanane triterpene that can be isolated from Isodon sculponeata .

HY-N19817

Gleditsioside H	Biochemical Assay Reagents	Others
Gleditsioside H is an oleanane-type bisdesmosidic saponin that can be isolated from the malformed fruits of Gleditsia sinensis .

HY-N17961

Kalopanaxsaponin I Septemloside I	Others	Inflammation/Immunology
Kalopanaxsaponin I (Septemloside I) is an oleanane-type triterpenoid that exists in the fruits of Stauntonia brachyanthera. Kalopanaxsaponin I inhibits LPS (HY-D1056)-induced nitric oxide production in macrophages, with a IC₅₀ of 80.25 μM .

HY-N19713

Araliasaponin XIV	Drug Derivative	Others
Araliasaponin XIV is an oleanane-type triterpene saponin that can be found in the roots of Aralia chinensis .

HY-N17243

Aesculinoside C	Others	Others
Aesculinoside C is an acylated polyhydroxy oleanane-type triterpene saponin that is found in the seeds of Aesculus chinensis .

HY-N11458

Raddeanoside R16	Others	Others
Raddeanoside R16 is an oleanane-type saponin, that can be isolated from the rhizoma of Anemone raddeana .

HY-N18092

Platycodin C	Others	Others
Platycodin C is an oleanane-type oligoglycoside and monoacetylated saponin found in the roots of Platycodon grandiflorum A. DC. (Campanulaceae) .

HY-N13724

Stipuleanoside R1	Others	Others
Stipuleanoside R1 is an oleanane-type saponin that can be isolated from the aerial parts (leaves and stems) of Panax bipinnatifidus .

HY-N19858

Millettiasaponin B	Drug Derivative	Cancer
Millettiasaponin B is an oleanane-type triterpene saponin found in the roots of Millettia speciosa. Millettiasaponin B can be used in leukemia research .

HY-N19870

Verbascosaponin Ilwensisaponin A; Mimengoside A	Drug Derivative	Inflammation/Immunology
Verbascosaponin (Ilwensisaponin A) is an orally active oleanane-triterpene saikosaponin found in crophularia auriculata ssp. pseudoauriculata. Verbascosaponin can be used for the research of inflammation .

HY-N16930

Phytolaccagenic acid 28-O-β-D-glucopyranosyl ester	Drug Derivative	Others
Phytolaccagenic acid 28-O-β-D-glucopyranosyl ester is a natural triterpene.

HY-N17570

*23α-Hydroxy-olean-12-en-3-one*	Drug Derivative	Others
23α-Hydroxy-olean-12-en-3-one (Compound 15) is a pentacyclic triterpenoid, which is a natural derivative of the oleanane skeleton .

HY-N17752

Phaseoloideside C	Others	Cancer
Phaseoloideside C is an oleanane-type triterpenoid saponin. Phaseoloideside C can be isolated from the seeds of Entada phaseoloides. Phaseoloideside C exhibits no cytotoxicity against hepatocellular carcinoma cells, esophageal carcinoma cells, cervical carcinoma cells, and colon carcinoma cells .

HY-N19813

Flaccidoside VI	NO Synthase	Others
Flaccidoside VI is an inhibitor of nitric oxide production belonging to oleanane-type triterpenoid saponins. Flaccidoside VI can be isolated from the rhizomes of Anemone flaccida. Flaccidoside VI exhibits significant inhibitory activity against lipopolysaccharide-induced nitric oxide production .

HY-N19857

Millettiasaponin A	Biochemical Assay Reagents	Cardiovascular Disease Metabolic Disease
Millettiasaponin A is an oleanane-type triterpenoid saponin found in the stems of Derris eriocarpa and roots of Millettia speciosa. Millettiasaponin A is 150 times sweeter than Sucrose (HY-B1779) at 1% concentration. Millettiasaponin A can be used in research on hypertension and obesity. .

HY-N19755

Clemontanoside-C	Fungal	Infection
Clemontanoside-C is an oleanane-based triterpenoid saponin and antifungal agent found in the roots of Lepidagathis cuspidata. Clemontanoside-C acts against Aspergillus flavus, Rhizopus stolinifer, Penicillum nodatum, and Aspergillus fumigatus. Clemontanoside-C can be used for the research of fungal infections .

HY-N17751

Phaseoloideside D	Others	Cancer
Phaseoloideside D is an oleanane-type triterpene saponin. Phaseoloideside D can be found in the seeds of Entada phaseoloides. Phaseoloideside D exhibits cytotoxicity against esophageal cancer, liver cancer, and cervical cancer cells. Phaseoloideside D can be used in colon cancer research .

HY-N19794

Derrisaponin A	Drug Derivative	Cardiovascular Disease Metabolic Disease
Derrisaponin A is an oleanane-type triterpenoid saponin and sweetener found in the stems of Derris eriocarpa, with sweetness intensity approximately 80 times that of Sucrose (HY-B1779) at 1% concentration. Derrisaponin A shows no acute toxic activity. Derrisaponin A can be used for research on hypertension, hyperglycemia, and obesity .

HY-E71272

β-Amyrin 28-monooxygenase	Biochemical Assay Reagents	Others
β-Amyrin 28-monooxygenase (EC 1.14.13.201), found in plants, is involved in the biosynthesis of oleanane-type triterpenoids, such as ginsenoside Ro. The enzyme from Medicago trunculata (CYP716A12) can also convert α-amyrin and lupeol to ursolic acid and betulinic acid, respectively.

HY-N19793

Derrisaponin B	Drug Derivative	Cardiovascular Disease Metabolic Disease
Derrisaponin B is an oleanane-type triterpenoid saponin and sweetener found in the stems of Derris eriocarpa How, with sweetness intensity approximately 2 times that of Sucrose (HY-B1779) at 1% concentration. Derrisaponin B exhibits sweet taste activity. Derrisaponin B can be used for research on hypertension, hyperglycemia, and obesity .

HY-N9826

Icterogenin	Bcl-2 Family	Cancer
Icterogenin is a selective inhibitor targeting the Bcl-XL/Bak BH3 domain peptide interaction and exhibits anti-leukemic activity. Icterogenin regulates protein interactions and affects tumor cell survival. Icterogenin is an oleanane-type triterpenoid compound that can be isolated from Lantana camara and is useful in the field of anti-tumor drug development .

HY-N17959

Vitalboside A	Others	Others
Vitalboside A is a triterpene found in the stem bark of Albizia gummifera .

HY-N19757

(3β,16α-Hydroxy)-3-O-(2'acetamido-2'-deoxy-β-D-glucopyranosyl) echinocystic acid	Fungal	Infection
3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid is an oleanane-type triterpenoid saponin. 3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid acts as a dermatophyte growth inhibitor with a MIC range of 6.25-25 μg/mL. 3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid can be used in the research of dermatophyte infections, bacterial infections and yeast infections .

Raddeanin A 1 Publications Verification	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Apoptosis PI3K Akt ERK mTOR Wnt β-catenin Wee1 JNK VEGFR CDK
Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, Wnt/β-catenin, Wee1, PI3K/AKT signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma .

Celosin I 1 Publications Verification	Triterpenes Structural Classification Celosia argentea Linn. Classification of Application Fields Terpenoids Metabolic Disease Amaranthaceae Plants Disease Research Fields Source Classification	Others
Celosin I, an oleanane-type triterpenoid saponin isolated from the seeds of Celosia argentea L, could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibits significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice .

Soyasapogenol C	Infection Triterpenes Trifolium repens Linn. Classification of Application Fields Leguminosae Terpenoids Plants Disease Research Fields Source Classification	HSV
Soyasapogenol C is an oleanane-type triterpenoid. Soyasapogenol C exhibits anti-HSV-1 activity, with an IC₅₀ of 18.9 μM .

Momordin II	Triterpenes Terpenoids Cucurbitaceae Plants Momordica charantia Linn. Source Classification	DNA/RNA Synthesis
Momordin II, an oleanane-type triterpene glycoside, is a ribosome inactivating protein. Momordin II inhibits cell-free protein synthesis, releases adenine from rat liver ribosomes and from DNA, and has no RNase activity .

Soyasaponin III	Triterpenes Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Plants Disease Research Fields Cancer Source Classification	Apoptosis
Soyasaponin III, a monodesmodic oleanane triterpenoid, is one of the main potentially bioactive saponins found in soy (Glycine max) and related products. Soyasaponin III can induce apoptosis in Hep-G2 cells .

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oleanane

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