131 Results for "

plant signaling

" in MedChemExpress (MCE) Product Catalog:
Products (131)

131 Results for "plant signaling" in MCE Product Catalog:

34
Artemisinin
Artemisinin
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34 Publications Verification
Cat. No.: HY-B0094
CAS No.: 63968-64-9
Synonyms: Qinghaosu; NSC 369397
Category:  

Infection Piscidia erythrina L. Neurological Disease Terpenoids Sesquiterpenes Plants Compositae Extract Disease Research Fields

Target:  

HCV Parasite Akt Ferroptosis

Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
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23
Narciclasine
Narciclasine
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23 Cited Publications
Cat. No.: HY-16563
CAS No.: 29477-83-6
Synonyms: Lycoricidinol
Category:  

Alkaloids Narcissus tazetta Linn. var. chinensis M.Roemer Amaryllidaceae Extract Plants Disease Research Fields Isoquinoline Alkaloids Cancer Agricultural Research

Target:  

ROCK

Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
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14
Cholesterol (from plant)
Cholesterol (from plant)
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14 Cited Publications
Cat. No.: HY-N0322D
CAS No.: 57-88-5
Category:  

Dioscoreaceae Extract Plants Dioscorea deltoidea Wall. ex Griseb. Steroids

Target:  

Endogenous Metabolite Estrogen Receptor/ERR Bacterial Liposome

Cholesterol (from plant) is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol (from plant) plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol (from plant) is also an endogenous estrogen-related receptor α (ERRα) agonist .
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12
Ginsenoside Rk1
Ginsenoside Rk1
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12 Cited Publications
Cat. No.: HY-N2515
CAS No.: 494753-69-4
Category:  

Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Inflammation/Immunology Araliaceae Extract

Target:  

NF-κB PI3K JAK Apoptosis

Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .
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11
Dioscin
Dioscin
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11 Cited Publications
Cat. No.: HY-N0124
CAS No.: 19057-60-4
Synonyms: Collettiside III; CCRIS 4123
Category:  

Plants Other Families Extract Disease Research Fields Cancer Steroids

Target:  

Autophagy Apoptosis

Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
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9
Neohesperidin
Neohesperidin
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9 Cited Publications
Cat. No.: HY-N0101
CAS No.: 13241-33-3
Synonyms: Hesperetin 7-O-neohesperidoside
Category:  

Rutaceae Extract Plants Other Families Extract Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology Citrus

Target:  

β-catenin Free Radical Scavengers Wnt

Neohesperidin is a flavonoid compound abundant in citrus plants with antioxidant and anti-inflammatory effects. Neohesperidin can upregulate the Wnt/β-catenin signaling pathway, enhance the nuclear translocation of β-catenin and the differentiation of bone marrow stromal cells .
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8
(Z)-Guggulsterone
(Z)-Guggulsterone
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8 Cited Publications
Cat. No.: HY-110066
CAS No.: 39025-23-5
Purity:  99.30%
Category:  

Commiphora myrrha (Nees) Engl. Burseraceae Extract Plants Disease Research Fields Cancer Steroids

Target:  

Apoptosis VEGFR Akt Angiotensin-converting Enzyme (ACE) SARS-CoV FXR

(Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis . (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection .
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8
Cyclo(Phe-Pro)
Cyclo(Phe-Pro)
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8 Cited Publications
Cat. No.: HY-P1934
CAS No.: 14705-60-3
Synonyms: Cyclo(phenylalanylprolyl); A-64863
Target:  

HCV Bacterial Antibiotic Reactive Oxygen Species (ROS)

Research Areas:  

Infection

Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance .
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6
N-Hydroxypipecolic acid
N-Hydroxypipecolic acid
0 Images
6 Cited Publications
Cat. No.: HY-N7378
CAS No.: 115819-92-6
Synonyms: 1-Hydroxy-2-piperidinecarboxylic acid; NHP
Category:  

Ketones, Aldehydes, Acids Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:  

Bacterial

N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection .
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5
Kinsenoside
Kinsenoside
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5 Cited Publications
Cat. No.: HY-N2292
CAS No.: 151870-74-5
Category:  

Natural Products Orchidaceae Extract Plants Anoectochilus Disease Research Fields Inflammation/Immunology

Target:  

Keap1-Nrf2 Apoptosis

Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD).
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4
Zinpyr-1
Zinpyr-1
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4 Cited Publications
Cat. No.: HY-D0155
CAS No.: 288574-78-7
Zinpyr-1 is a zinc-responsive fluorescent indicator and a membrane-permeable metal-binding probe. Zinpyr-1 forms a complex with Mn 2+ ions and generates a fluorescence turn-on signal. Zinpyr-1 binds to free zinc ions in serum, enabling quantitative detection of free zinc concentration. Zinpyr-1 produces fluorescence signals reflecting the relative zinc concentration in plant root cells, localizes to specific layers of plant root cells, and can be used to support analyses related to plant zinc transporter mutations and homeostasis .
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2
Solanesol
Solanesol
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2 Cited Publications
Cat. No.: HY-N0576
CAS No.: 13190-97-1
Category:  

Other Terpenoids Neurological Disease Terpenoids Plants Other Families Extract Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite Heme Oxygenase (HO) HSP p38 MAPK Akt Apoptosis Caspase PARP

Solanesol is an orally active aliphatic terpene alcohol. Solanesol is mainly found in tobacco and other Solanaceae plants. Solanesol induces HO-1 and Hsp70 expression, activates p38 and Akt signaling pathways, and inhibits Apoptosis (reduces caspase-3 and PARP cleavage). Solanesol has antioxidant, anti-inflammatory, and neuroprotective activities. Solanesol can be used in the research of Huntington's disease, alcoholic liver disease, chronic inflammatory pain, anxiety, Alzheimer's disease, and bipolar disorder .
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2
Bikinin
Bikinin
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2 Cited Publications
Cat. No.: HY-12524
CAS No.: 188011-69-0
Purity:  99.96%
Synonyms: Abrasin
Target:  

GSK-3

Research Areas:  

Others

Bikinin is a non-steroidal, ATP-competitive inhibitor of plant GSK-3/Shaggy-like kinases and activates BR (brassinosteroids) signaling.
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2
Phellodendrine chloride
Phellodendrine chloride
0 Images
2 Cited Publications
Cat. No.: HY-N0735
CAS No.: 104112-82-5
Category:  

Rutaceae Extract Alkaloids Phellodendron amurense Rupr. Phenols Polyphenols Plants Disease Research Fields Isoquinoline Alkaloids Cancer

Target:  

Autophagy Apoptosis AMPK mTOR STAT Interleukin Related PKC p38 MAPK NF-κB COX Reactive Oxygen Species (ROS) PI3K Akt MMP

Phellodendrine chloride is an orally active plant alkaloid. Phellodendrine chloride inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine chloride promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine chloride can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine chloride suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine chloride inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine chloride has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway .
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2
Esculentoside H
Esculentoside H
0 Images
2 Cited Publications
Cat. No.: HY-N2205
CAS No.: 66656-92-6
Category:  

Phytolaccaceae Extract Triterpenes Terpenoids Phytolacca acinosa Roxb. Plants Disease Research Fields Cancer

Target:  

NF-κB JNK

Esculentoside H (EsH) is a saponin isolated from the root extract of perennial plant Phytolacca esculenta . Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease . Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the JNK1/2 and NF-κB signaling-mediated matrix metalloproteinases-9 (MMP-9) expression .
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2
3-Indoleacetonitrile
3-Indoleacetonitrile
0 Images
2 Cited Publications
Cat. No.: HY-Y0136
CAS No.: 771-51-7
Category:  

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Influenza Virus HSV VSV

3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV .
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2
Arabinose
Arabinose
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2 Cited Publications
Cat. No.: HY-N2353
CAS No.: 147-81-9
Synonyms: (±)​-​Arabinose; DL-​Arabinose; dl-​Arabinose
Category:  

Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides

Target:  

Environmental Pollutants Endogenous Metabolite

Arabinose is a pentose sugar commonly found in plants. Arabinose alleviates immune dysregulation and inflammation by promoting balanced immune responses and reducing inflammation. Arabinose induces cytotoxicity, autophagy (Autophagy), and cell cycle arrest in breast cancer cells through the p38-MAPK signaling pathway. Arabinose activates the ACSS2-PPARγ/TFEB-AMPK axis in neuroblastoma cells, thereby exerting neuromodulatory/antidepressant effects. Arabinose can also be used as an intermediate in compound synthesis. Arabinose may be applied in research related to immune inflammation, depression, breast cancer, and other diseases .
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2
Brassinin
Brassinin
0 Images
2 Cited Publications
Cat. No.: HY-111334
CAS No.: 105748-59-2
Purity:  99.74%
Synonyms: Brassinine
Category:  

Beassica pekinensis (Lour. ) Rupr. Alkaloids Cruciferae Extract Cosmetic Research Plants Disease Research Fields Cancer Indole Alkaloids

Target:  

Endogenous Metabolite Indoleamine 2,3-Dioxygenase (IDO) Apoptosis Autophagy Paraptosis Reactive Oxygen Species (ROS) Tie Akt PERK PI3K mTOR Ribosomal S6 Kinase (RSK)

Brassinin is an indole derivative found in cruciferous plants. Brassinin acts as an IDO inhibitor (Ki = 97.7 μM). Brassinin inhibits angiogenesis and induces apoptosis, autophagy, paraptosis, ROS production, and ER stress. Brassinin selectively stimulates lysosomal degradation of Tie2 and promotes lysosomal and proteasomal degradation of FGFR1 in endothelial cells, downregulating AKT and ERK phosphorylation. Brassinin inhibits endothelial cell proliferation, migration, tube formation, spheroid sprouting, and angiogenesis. Brassinin inhibits PI3K/Akt/mTOR/S6K1 signaling, upregulates p21 and p27, and induces G1 phase cell cycle arrest through RB hypophosphorylation. Brassinin inhibits tyrosinase catalytic activity, reduces tyrosinase mRNA, and inhibits MITF nuclear translocation. Brassinin is used for research on triple-negative breast cancer, chronic myeloid leukemia, colon cancer, glioma, atherosclerosis, and skin cancer .
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1
Potassium chloride, for cell culture
Potassium chloride, for cell culture
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1 Cited Publications
Cat. No.: HY-Y0537E
CAS No.: 7447-40-7
Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells .
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Propylparaben
Propylparaben
0 Images
1 Cited Publications
Cat. No.: HY-N2026
CAS No.: 94-13-3
Synonyms: Propyl parahydroxybenzoate; Propyl 4-hydroxybenzoate
Category:  

Infection Natural Products Preservatives Monophenols Phenols Cosmetic Research Endogenous metabolite Disease Research Fields Food Research

Target:  

Bacterial Estrogen Receptor/ERR Sodium Channel PI3K JNK Akt Apoptosis

Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is an orally active weak estrogen receptor agonist. Propylparaben regulates the PI3K-AKT and JNK signaling pathways, and induces oxidative stress. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods, and can be used in studies related to ovarian aging and myocardial ischemia-reperfusion injury .
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