112 Results for "

polyphenol

" in MedChemExpress (MCE) Product Catalog:
Products (112)

112 Results for "polyphenol" in MCE Product Catalog:

68
(-)-Epigallocatechin Gallate
(-)-Epigallocatechin Gallate
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68 Publications Verification
Cat. No.: HY-13653
CAS No.: 989-51-5
Purity:  99.75%
Synonyms: EGCG; Epigallocatechol Gallate
Category:  

Anti-aging Other Families Extract Endogenous metabolite Plant Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology Cancer

Target:  

Endogenous Metabolite Apoptosis

(-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .
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20
Punicalagin
Punicalagin
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20 Cited Publications
Cat. No.: HY-N0063
CAS No.: 65995-63-3
Category:  

Infection Plant Punicaceae Extract Punica granatum L. Extract Metabolic Disease Phenols Polyphenols Disease Research Fields

Target:  

SARS-CoV HBV

Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L.. Punicalagin is a reversible and non-competitive 3CL pro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19 .
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11
Isoquercitrin
Isoquercitrin
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11 Cited Publications
Cat. No.: HY-N1445
CAS No.: 482-35-9
Synonyms: Isoquercetin; Quercetin 3-glucoside
Category:  

Flavonols Plant Flavonoids Phenols Polyphenols Disease Research Fields Apocynum venetum Linn. Extract Cancer Apocynaceae Extract

Target:  

NF-κB NO Synthase

Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway . Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies .
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11
Procyanidin C1
Procyanidin C1
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11 Cited Publications
Cat. No.: HY-N2342
CAS No.: 37064-30-5
Synonyms: PCC1
Category:  

Rosaceae Extract Crataegus pinnatifida Bge. Extract Plant Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Disease Research Fields Biflavones Cancer

Target:  

Apoptosis

Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice .
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8
Bergenin
Bergenin
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8 Cited Publications
Cat. No.: HY-N0017
CAS No.: 477-90-7
Synonyms: Cuscutin
Category:  

Infection Saxifragaceae Extract Plant Bergenia purpurascens (Hook. f. et Thoms.) Engl. Extract Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

NF-κB Autophagy Apoptosis Bacterial Fungal Virus Protease

Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties .
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6
Arbutin
Arbutin
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6 Cited Publications
Cat. No.: HY-N0192
CAS No.: 497-76-7
Synonyms: β-Arbutin
Category:  

Saxifragaceae Extract Human Gut Microbiota Metabolites Plant Bergenia purpurascens (Hook. f. et Thoms.) Engl. Extract Phenols Endogenous metabolite Disease Research Fields Cancer

Target:  

Tyrosinase Endogenous Metabolite

Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Ki app values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents . Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties .
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5
Protocatechualdehyde
Protocatechualdehyde
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5 Cited Publications
Cat. No.: HY-N0295
CAS No.: 139-85-5
Synonyms: Catechaldehyde; Protocatechuic aldehyde; Rancinamycin IV
Category:  

Infection Plant Anti-aging Phenols Polyphenols Salvia miltiorrhiza Bunge Extract Disease Research Fields Cancer Labiatae Extract

Target:  

Reactive Oxygen Species (ROS) Bacterial Endogenous Metabolite

Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent .
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5
Isorhapontigenin
Isorhapontigenin
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5 Cited Publications
Cat. No.: HY-N2593
CAS No.: 32507-66-7
Category:  

Plant Gnetaceae Extract Stilbenes Phenols Polyphenols Disease Research Fields Inflammation/Immunology Gnetum cleistostachyum C. Y. Cheng Extract

Target:  

Carnitine Palmitoyltransferase (CPT) Reactive Oxygen Species (ROS) Autophagy Apoptosis NF-κB PI3K Akt MMP Keap1-Nrf2

Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes .
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4
Pyrogallol
Pyrogallol
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4 Cited Publications
Cat. No.: HY-N1579
CAS No.: 87-66-1
Category:  

Infection Phenols Microorganism Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Fungal Apoptosis

Pyrogallol is a polyphenol compound, which has anti-fungal and anti-psoriatic properties. Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions.
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3
(-)-Gallocatechin gallate
(-)-Gallocatechin gallate
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3 Cited Publications
Cat. No.: HY-N0522
CAS No.: 4233-96-9
Synonyms: (-)-Gallocatechol gallate
Category:  

Plant Flavonoids Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Extract Disease Research Fields Cancer Theaceae Extract

Target:  

COMT

(-)-Gallocatechin gallate is the polyphenol isolated from tea, with cancer-preventive activities.
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2
Hippuric acid
Hippuric acid
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2 Cited Publications
Cat. No.: HY-W016562
CAS No.: 495-69-2
Synonyms: Benzoylglycine
Category:  

Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Keap1-Nrf2 MMP Reactive Oxygen Species (ROS) TGF-beta/Smad

Hippuric Acid is an orally active metabolite. Hippuric Acid can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Hippuric Acid decreases NRF2, MMP9 and leads to ROS accumulation. Hippuric Acid activates TGFβ/SMAD signaling. Hippuric Acid improves hyperuricemia and colitis. Hippuric Acid can also be used in cardiovascular disease research . .
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2
4-Hydroxyphenylacetic acid
4-Hydroxyphenylacetic acid
0 Images
2 Cited Publications
Cat. No.: HY-N1902
CAS No.: 156-38-7
Category:  

Human Gut Microbiota Metabolites Plant Monophenols Metabolic Disease Phenols Compositae/Asteraceae Extract Endogenous metabolite Disease Research Fields Aster tataricus Linn. f. Extract

Target:  

Keap1-Nrf2 Endogenous Metabolite

4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 .
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2
(+)-Gallocatechin
(+)-Gallocatechin
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2 Cited Publications
Cat. No.: HY-N0521A
CAS No.: 970-73-0
Category:  

Plant Flavonoids Flavanols Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Extract Disease Research Fields Cancer Theaceae Extract

Target:  

Others

(+)-Gallocatechin is a polyphenol compound from green tea, possesses anticancer activity .
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2
Tea polyphenol
Tea polyphenol
0 Images
2 Cited Publications
Cat. No.: HY-N1925
CAS No.: 84650-60-2
Category:  

Plant Phenols Camellia sinensis (L.) O. Ktze. Extract Research on Agricultural Breeding Disease Research Fields Inflammation/Immunology Cancer Theaceae Extract Agricultural Research

Target:  

Apoptosis Autophagy

Tea polyphenol is the floorboard of phenolic compounds in tea. Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism .
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2
Sodium hippurate, 98%
Sodium hippurate, 98%
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2 Cited Publications
Cat. No.: HY-W014841
CAS No.: 532-94-5
Synonyms: N-Benzoylglycine sodium, 98%
Sodium hippurate, 98% is an orally active metabolite. Sodium hippurate, 98% can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Sodium hippurate, 98% decreases NRF2, MMP9 and leads to ROS accumulation. Sodium hippurate, 98% activates TGFβ/SMAD signaling. Sodium hippurate, 98% improves hyperuricemia and colitis. Sodium hippurate, 98% can also be used in cardiovascular disease research . .
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2
Isoquercitrin (Standard)
Isoquercitrin (Standard)
0 Images
2 Cited Publications
Cat. No.: HY-N1445R
CAS No.: 482-35-9
Synonyms: Isoquercetin (Standard); Quercetin 3-glucoside (Standard)
Category:  

Flavonols Plant Flavonoids Phenols Polyphenols Apocynum venetum Linn. Extract Apocynaceae Extract

Target:  

Reference Standards NF-κB NO Synthase

Isoquercetin (Standard) is the analytical standard of Isoquercetin. This product is intended for research and analytical applications. Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway . Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies .
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1
Agrimol B
Agrimol B
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1 Cited Publications
Cat. No.: HY-N0704
CAS No.: 55576-66-4
Category:  

Plant Agrimonia pilosa Ledeb. Extract Rosaceae Extract Metabolic Disease Phenols Polyphenols Disease Research Fields

Target:  

Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial

Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27 .
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1
Methyl 3,4-dihydroxybenzoate
Methyl 3,4-dihydroxybenzoate
0 Images
1 Cited Publications
Cat. No.: HY-Z0548
CAS No.: 2150-43-8
Synonyms: Protocatechuic acid methyl ester; Methyl protocatechuate
Category:  

Plant Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Extract Disease Research Fields Inflammation/Immunology Theaceae Extract

Target:  

Keap1-Nrf2 Apoptosis

Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect .
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1
Procyanidol B4
Procyanidol B4
0 Images
1 Cited Publications
Cat. No.: HY-107208
CAS No.: 29106-51-2
Purity:  99.89%
Synonyms: (-)-Procyanidin B4
Category:  

Plant Flavonoids Phenols Polyphenols Other Families Extract Disease Research Fields Inflammation/Immunology Biflavones

Target:  

Free Radical Scavengers Reactive Oxygen Species (ROS) COX Interleukin Related NO Synthase

Procyanidol B4 ((-)-Procyanidin B4) is an orally active polyphenol found in Q.gilva. Procyanidol B4 exerts antioxidant activity by scavenging DPPH (HY-112053) (IC50: 12.15 μM) and Nitro blue tetrazolium chloride (NBT) (HY-15925) (IC50: 8.67 μM). Procyanidol B4 exhibits anti-inflammatory activity by inhibiting the expression of COX-2 and IL-1β and iNOS .
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1
(±)-Catechin
(±)-Catechin
0 Images
1 Cited Publications
Cat. No.: HY-B1890
CAS No.: 7295-85-4
Synonyms: rel-Cianidanol; rel-Catechuic acid
Category:  

Cardiovascular Disease Neurological Disease Theaceae Extract Infection Plant Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Extract Disease Research Fields Inflammation/Immunology

Target:  

COX

(±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. (±)-Catechin has two forms, (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. (-)-Catechin can effectively promote hBM-MSC adipocyte differentiation and increase adiponectin and PPARγ levels. (±)-Catechin has anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective and neuroprotective effects .
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