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Results for "

polyunsaturated fatty acid chloride

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FAAH (1) Free Fatty Acid Receptor (2) Apolipoprotein (1) Apoptosis (2) Biochemical Assay Reagents (17) COX (2) Drug Derivative (5) Drug Intermediate (2) Drug Metabolite (2) Endogenous Metabolite (39) Environmental Pollutants (3) GLUT (1) Glutathione Peroxidase (1) Histone Demethylase (6) Insecticide (1) Interleukin Related (1) Isotope-Labeled Compounds (9) Lipocalin Family (1) Lipoxygenase (4) LXR (2) Melatonin Receptor (2) PKC (3) Potassium Channel (1) Proteasome (1) Reactive Oxygen Species (ROS) (1) Reference Standards (4) SOD (1) Stearoyl-CoA Desaturase (SCD) (2) Tau Protein (1) TNF Receptor (1) TRP Channel (2) Tyrosine Hydroxylase (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (13) Infection (1) Inflammation/Immunology (13) Metabolic Disease (35) Neurological Disease (15)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Solvents (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Chloride Channel Sodium Chloride Cotransporter (NCC) Free Fatty Acid Receptor Fatty Acid Synthase (FASN) FATP FABP FAAH ELOVL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109590

Arachidonic acid Maximum Cited Publications 55 Publications Verification Immunocytophyt	Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function .

HY-B0660

Eicosapentaenoic Acid 25+ Cited Publications EPA; Timnodonic acid	Endogenous Metabolite Histone Demethylase	Neurological Disease Cancer
Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .

HY-N0121

Sesamin 10+ Cited Publications	Stearoyl-CoA Desaturase (SCD)	Neurological Disease
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-113130

Eicosadienoic acid 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Eicosadienoic acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues .

HY-W013215

Adrenic acid 1 Publications Verification cis-7,10,13,16-Docosatetraenoic acid	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) is a naturally polyunsaturated fatty acid in the adrenal gland, brain, kidney, and vasculature. Adrenic Acid can regulate the vascular tone in arteries of the adrenal cortex. Adrenic Acid also is an inflammation enhancer in non-alcoholic fatty liver disease .

HY-19996

AH-7614 5+ Cited Publications	Free Fatty Acid Receptor	Metabolic Disease
AH-7614 is a potent and selective FFA4 (GPR120) antagonist, with pIC₅₀s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC₅₀<4.6). AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist .

HY-21268

Methyl linolenate 1 Publications Verification Linolenic acid methyl ester	Environmental Pollutants Melatonin Receptor	Metabolic Disease
Methyl linolenate is a polyunsaturated fattly acid (PUFA). Methyl linolenate has an anti-melanogenesis activity with an IC₅₀ of 60 μM. Methyl linolenate can also be used for studies of the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids .

HY-W749411

Malondialdehyde tetrabutylammonium	Biochemical Assay Reagents Endogenous Metabolite	Others
Malondialdehyde tetrabutylammonium is a quaternary ammonium salt formed by the decomposition of polyunsaturated fatty acids in plant cell membranes. Malondialdehyde tetrabutylammonium can be used for the quantification of malondialdehyde, a biomarker of lipid peroxidation .

HY-109590A

Arachidonic acid sodium salt Maximum Cited Publications 55 Publications Verification Immunocytophyt sodium salt	Endogenous Metabolite	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Arachidonic acid (Immunocytophyt) sodium salt is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid sodium salt also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid sodium salt improves cognitive response and cardiovascular function .

HY-Y1887

Cottonseed oil	Environmental Pollutants Biochemical Assay Reagents Insecticide	Cardiovascular Disease Infection Inflammation/Immunology
Cottonseed oil is an edible oil extracted from the seeds of cotton (Gossypium hirsutum). Its fatty acid composition includes 26-35% saturated fatty acids, 42-52% polyunsaturated fatty acids, and 18-24% monounsaturated fatty acids. Cottonseed oil is regarded as an Insecticide, as it is used to protect the trunks of apple trees from damage by the apple clearwing moth. Cottonseed oil possesses anti-inflammatory and cardioprotective properties. It also has extensive applications in many fields such as biofuels, animal husbandry, cosmetics, agriculture, and chemical industry .

HY-131897

1-Stearoyl-2-arachidonoyl-sn-glycerol 1 Publications Verification	PKC TRP Channel Endogenous Metabolite	Neurological Disease
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity .

HY-N0729D

Linoleic acid,suitable for cell culture	Glutathione Peroxidase SOD	Cardiovascular Disease
Linoleic acid is a critical component of polyunsaturated fatty acids. Linoleic acid reduces GSH-PX and T-SOD activities. Linoleic acid functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid can cause acute oxidative damage to red blood cells, ultimately leading to partial acute anemia. Linoleic acid can be used in the research of skin diseases associated with linoleic acid deficiency .

HY-18282

AZ876	LXR	Cardiovascular Disease Metabolic Disease Cancer
AZ876 is a selective, orally active agonist of liver X receptor (LXRα/β) (K_i=0.007 μM [LXRα, human], 0.011 μM [LXRβ, human]. AZ876 induces the expression of target genes such as ABCA1 and ABCG1, promotes reverse cholesterol transport (RCT) and regulates lipid metabolism and anti-inflammatory effects. AZ876 increases cardiac polyunsaturated fatty acid levels, reduces myocardial fibrosis, and reduces lesion area and monocyte adhesion in atherosclerosis models. AZ876 can be used in cardiovascular disease research, such as preventing and treating β-adrenergic-induced cardiac diastolic dysfunction and inhibiting the progression of atherosclerosis .

HY-139066

Punicic acid 1 Publications Verification Trichosanic acid	TNF Receptor GLUT Proteasome Tau Protein PKC	Neurological Disease Metabolic Disease Inflammation/Immunology
Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways .

HY-W089800

trans-2-Nonenal trans-2-Nonen-1-al	COX Lipoxygenase Apoptosis	Cardiovascular Disease Inflammation/Immunology
trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .

HY-119546

Pinolenic acid PNLA	Free Fatty Acid Receptor	Inflammation/Immunology
Pinolenic acid (PNLA) is a polyunsaturated fatty acid that can be isolated from Pinus orientalis and Pinus pinaster seed oil. Pinolenic acid has anti-inflammatory and lipid-lowering activities .

HY-115437

Methyl all-cis-7,10,13,16,19-docosapentaenoate	Biochemical Assay Reagents	Others
Methyl all-cis-7,10,13,16,19-docosapentaenoate is a long-chain polyunsaturated omega-3 fatty acid esters.

HY-113120

Stearidonic acid 6Z,9Z,12Z,15Z-Octadecatetraenoic acid	Lipoxygenase	Metabolic Disease
Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an orally active polyunsaturated fatty acid found in blackcurrant seed oil. Stearidonic acid can inhibit 5-lipoxygenase and reduce leukotriene and 5-HETE synthesis. Stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can be used for the research of metabolic disease .

HY-139285

Arachidonic acid-alkyne	Endogenous Metabolite	Metabolic Disease
Arachidonic acid-alkyne is aω‑alkynyl lipid surrogates for polyunsaturated fatty acid. Arachidonic acid-alkyne has low rates of oxidation. Arachidonic acid-alkyne can be used for tracking the polyunsaturated fatty acids .

HY-125139

omega-3 Arachidonic acid ethyl ester, in ethanol, 98% ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%	Biochemical Assay Reagents	Cardiovascular Disease Others
omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

HY-17639

Navamepent RX-10045	Biochemical Assay Reagents	Inflammation/Immunology
Navamepent is an analog of naturally occurring resolvin E1 (a major dietary omega-3 polyunsaturated fatty-acid metabolite) with potent anti-inflammatory and cell survival benefits. Navamepent is highly effective against dry eye and goblet cell loss thereby accelerating tear production. Also, Navamepent can reduce corneal inflammation, epithelial damage, and accelerate corneal tissue repair. In addition, Navamepent can inhibit the release of several key proinflammatory mediators from corneal epithelial cells. Navamepent is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0660R

Eicosapentaenoic Acid (Standard) EPA (Standard); Timnodonic acid (Standard)	Reference Standards Endogenous Metabolite Histone Demethylase	Neurological Disease Cancer
Eicosapentaenoic Acid (Standard) is the analytical standard of Eicosapentaenoic Acid. This product is intended for research and analytical applications. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .

HY-N0121A

(-)-Sesamin	Others	Others
(-)-Sesamin isolated from Asarum forbesii Maxim, is an isomer of Sesamin. Sesamin is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis .

HY-135298

Soya fatty acids	Environmental Pollutants	Metabolic Disease
Soya fatty acids is a class of polyunsaturated fatty acids extracted from soybean .

HY-P2976

Lipoxygenase, general LOX	Endogenous Metabolite	Others
Lipoxygenase, general (LOX) is a dioxygenase, is often used in biochemical studies. Lipoxygenase, general catalyzes the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid .

HY-115369

Methyl (13Z,16Z,19Z)-docosatrienoate	Biochemical Assay Reagents	Others
cis-13,16,19-Docosatrienoic acid methyl ester is an ester form of docosatrienoic acid, a rare omega-3 fatty acid not found in the normal phospholipid polyunsaturated fatty acid pool Easily detectable, it inhibits the binding of [3H]-LTB4 to porcine neutrophils at a concentration of 5 μM. Methyl docosatrienoate is more fat-soluble than the free acid and may be more desirable than the free acid in some formulations.

HY-158812

Eicosapentaenoyl-L-carnitine chloride	Drug Derivative	Metabolic Disease
Eicosapentaenoyl-L-carnitine chloride is a long-chain acylcarnitine composed of Eicosapentaenoic Acid (HY-B0660) and L-Carnitine (HY-B0399). The levels of Eicosapentaenoyl-L-carnitine chloride are increased in the eyes of mice fed a diet high in n-3/n-6 polyunsaturated fatty acids (PUFAs) in a mouse model of myopia induced by out-of-focus lenses .

HY-N7140R

Gamma-Linolenic acid (Standard) 5+ Cited Publications γ-Linolenic acid (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Gamma-Linolenic acid (Standard) is the analytical standard of Gamma-Linolenic acid. This product is intended for research and analytical applications. Gamma-linolenic acid (γ-Linolenic acid) is an omega-6 (n-6), 18 carbon (18C-) polyunsaturated fatty acid (PUFA) extracted from Perilla frutescens. Gamma-linolenic acid supplements could restore needed PUFAs and mitigate the disease .

HY-165061

5(Z),11(Z),14(Z)-Eicosatrienoic acid Sciadonic acid	Apolipoprotein	Inflammation/Immunology
5(Z),11(Z),14(Z)-Eicosatrienoic acid (Sciadonic acid), a polyunsaturated fatty acid sourced from maritime pine seed oil, gymnospermae leaves and seeds, and freshwater gastropods, has been shown to reduce high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1 when included in their diet. In vitro studies indicate that it diminishes cholesterol efflux, and when applied topically in its methyl ester form, it alleviates inflammatory processes, likely by displacing arachidonic acid from phospholipid pools and lowering concentrations of downstream inflammatory mediators such as prostaglandin E2 and leukotrienes.

HY-145548

cis-4,10,13,16-Docosatetraenoic acid	Endogenous Metabolite	Others
cis-4,10,13,16-Docosatetraenoic acid is a long chain polyunsaturated fatty acid derived from the lipids of rat testis .

HY-120987

Ethyl stearidonate	Biochemical Assay Reagents	Others
6,9,12,15-octadecatetraenoic acid (Glycerol α-monoelaidate) is a rare omega-3 series polyunsaturated fatty acid. In normal people, it accounts for less than 0.25% of serum phospholipid fatty acids. It is found in certain natural oils, such as echium and blackcurrant, and to the extent that these oils are incorporated into nutraceuticals, stearidonic acid can be an important polyunsaturated species in the human diet. Ethyl stearidonic acid, an ester of the free acid, is less water soluble but more suitable for formulating stearidonic acid-containing diets and dietary supplements.

HY-120958

Nisinic acid C24:6n-3	Endogenous Metabolite	Metabolic Disease
Nisinic acid (C24:6n-3) is a very long chain polyunsaturated fatty acid (VLCPUFA) that is a component of triglycerides and cholesterol esters in mouse and rat testis .

HY-130238

(±)8-HDHA (±)8-HDoHE; 8-hydroxy Docosahexaenoic acid; (±)8-HDoHE	Endogenous Metabolite	Metabolic Disease
(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

HY-116015

Dihomo-γ-Linolenic acid methyl ester	Endogenous Metabolite	Inflammation/Immunology
Dihomo-γ-Linolenic acid methyl ester is the methyl ester form of Dihomo-γ-Linolenic Acid (DGLA) (HY-A0143). Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is metabolized mainly through the cyclooxygenase (COX) pathway to the anti-inflammatory eicosanoid prostaglandin (PG) E1. Dihomo-γ-Linolenic acid has anti-inflammatory and antiproliferation effects .

HY-130288

(±)13-HDHA (±)13-HDoHE; 13-hydroxy Docosahexaenoic acid; (±)13-HDoHE	Lipoxygenase	Inflammation/Immunology
(±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra is shown to metabolize DHA to 13(R)-HDHA, presumably via the 11R-lipoxygenase activity. (±)13-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.

HY-126720

N-Lignoceroyl Taurine	Endogenous Metabolite	Metabolic Disease
N-Lignoceroyl Taurine is an arachidonoyl amino acid and taurine conjugate with a fatty acid that can be isolated from bovine brain. N-Lignoceroyl Taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of the brain and spinal cord of wild-type and fatty acid amide hydrolase (FAAH) knockout mice. N-Lignoceroyl Taurine levels were 23-26-fold higher in FAAH ^-/- mice compared to wild-type mice, suggesting that FAAH utilizes N-Lignoceroyl Taurine as a substrate. However, in vitro experiments with purified FAAH showed that N-Lignoceroyl Taurine was hydrolyzed 2,000-fold slower in FAAH compared to oleoylethanolamide. N-Acyl Taurines with polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) calcium channel family, including TRPV1 and TRPV4.

HY-W011269

Eicosapentaenoic Acid sodium 25+ Cited Publications EPA sodium; Timnodonic acid sodium	Endogenous Metabolite Histone Demethylase	Cardiovascular Disease Metabolic Disease Cancer
Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation .

HY-117057S

Hexaenoic acid-d6	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Hexaenoic acid-d₆ is deuterium labeled Hexaenoic acid. Very long chain polyunsaturated fatty acids (VLCPUFAs) are important components of ceramides and sphingomyelin and are present in retina, sperm, and brain. Tetratriaconta-16(Z),19(Z),22(Z),25(Z),28(Z),31(Z)-hexaenoic acid is a C34:6 VLCPUFA whose specific biological actions are largely unknown. This VLCPUFA, along with others, has been investigated for its role in activating protein kinase C .

HY-124187

Pinolenic acid ethyl ester Ethyl pinolenate	Biochemical Assay Reagents	Others
Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

HY-169030

Diarachidonin	Biochemical Assay Reagents	Metabolic Disease
Diarachidonin is a diacylglycerol that contains the ω-6 polyunsaturated 20-carbon fatty acid Arachidic acid (HY-W004260).

HY-124303

4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic acid	Biochemical Assay Reagents	Metabolic Disease
4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic acid is a polyunsaturated fatty acid (PUFA).

HY-122504

Linoleoyl glycine	Potassium Channel	Neurological Disease
Linoleoyl glycine is a modified polyunsaturated fatty acid. Linoleoyl glycine has activating effects on human KCNQ1/KCNE1 (hKCNQ1/hKCNE1) channels expressed in Xenopus oocytes .

HY-134544

Calendic acid	Apoptosis	Cancer
Calendic acid (8(E),10(E),12(Z)-Octadecatrienoic acid) is a conjugated polyunsaturated fatty acid (PUFA) that can be isolated from C. officinalis seed oil. Calendic acid has anticancer activity .

HY-N0121R

Sesamin (Standard)	Stearoyl-CoA Desaturase (SCD) Reference Standards	Neurological Disease
Sesamin (Standard) is the analytical standard of Sesamin. This product is intended for research and analytical applications. Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-127023

Eicosapentaenoyl serotonin EPA-5-HT	Endogenous Metabolite FAAH Interleukin Related Tyrosine Hydroxylase	Metabolic Disease
Eicosapentaenoyl serotonin (EPA-5-HT) is an endogenous fatty acid-serotonin conjugate lipid mediator. Eicosapentaenoyl serotonin acts as an inhibitor of fatty acid amide hydrolase (FAAH). Eicosapentaenoyl serotonin suppresses IL-17 release in Concanavalin A (HY-P2149)-stimulated human peripheral blood mononuclear cells. Eicosapentaenoyl serotonin is regulated by polyunsaturated fatty acids and modulates intestinal immunity and Th17 signaling. Eicosapentaenoyl serotonin can be used for the study of inflammatory bowel disease-related mechanisms .

HY-W127851

CLA Cypridina luciferin analog	Biochemical Assay Reagents	Others Cancer
CLA, or conjugated linoleic acid, is a polyunsaturated fatty acid that occurs naturally in a variety of animal products, such as meat and dairy. It has several potential benefits for human health, including the ability to reduce body fat mass, improve insulin sensitivity, and reduce inflammation. CLA has been extensively studied for its effects on weight loss and muscle growth, as well as its potential role in preventing chronic diseases such as heart disease and cancer. Additionally, it can be taken as a dietary supplement in capsule form.

HY-W753927

9(Z),12(E)-Octadecadienoic Acid C18:2(9E,12Z); C18:2 n-6	Endogenous Metabolite	Metabolic Disease
9(E),12(Z)-Octadecadienoic acid is an ω-6 polyunsaturated fatty acid and an isomer of linoleic acid (HY-N0729) that contains a trans double bond at the C9 position. It has been found as a minor component of bovine milk fat and in partially hydrogenated vegetable oils. 9(E),12(Z)-Octadecadienoic acid levels increase in rabbit meat following supplementation with heated sunflower oil, α-tocopheryl acetate, and zinc.

HY-W746625

all-cis-4,7,10,13,16-Docosapentaenoic acid methyl ester all-cis-4,7,10,13,16-DPA methyl ester	Drug Derivative	Cardiovascular Disease Neurological Disease Inflammation/Immunology
all-cis-4,7,10,13,16-Docosapentaenoic acid methyl ester (all-cis-4,7,10,13,16-DPA methyl ester) is the methyl ester derivative of all-cis-4,7,10,13,16-Docosapentaenoic acid, that can be used as a nutritional supplement to increase all-cis-4,7,10,13,16-Docosapentaenoic acid intake. all-cis-4,7,10,13,16-Docosapentaenoic acid is a long-chain polyunsaturated fatty acid, that plays a role in cardiovascular health, neuroprotection, and inflammation regulation .

HY-18282R

AZ876 (Standard)	LXR	Cardiovascular Disease Metabolic Disease Cancer
AZ876 (Standard) is the analytical standard of AZ876. This product is intended for research and analytical applications. AZ876 is a selective, orally active agonist of liver X receptor (LXRα/β) (Ki=0.007 μM [LXRα, human], 0.011 μM [LXRβ, human]. AZ876 induces the expression of target genes such as ABCA1 and ABCG1, promotes reverse cholesterol transport (RCT) and regulates lipid metabolism and anti-inflammatory effects. AZ876 increases cardiac polyunsaturated fatty acid levels, reduces myocardial fibrosis, and reduces lesion area and monocyte adhesion in atherosclerosis models. AZ876 can be used in cardiovascular disease research, such as preventing and treating β-adrenergic-induced cardiac diastolic dysfunction and inhibiting the progression of atherosclerosis .

HY-B0660S1

Eicosapentaenoic acid 1,2,3,4,5-13C5 EPA 1,2,3,4,5-13C, FA 20:5-¹³C₅	Isotope-Labeled Compounds Endogenous Metabolite Histone Demethylase	Neurological Disease Cancer
Eicosapentaenoic acid 1,2,3,4,5- ¹³C₅ (EPA 1,2,3,4,5- ¹³C, FA 20:5- ¹³C₅) is ¹³C labeled Eicosapentaenoic Acid. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .

Cat. No.	Product Name	Type

HY-Y1887

Cottonseed oil

Biochemical Assay Reagents

Cottonseed oil is an edible oil extracted from the seeds of cotton (Gossypium hirsutum). Its fatty acid composition includes 26-35% saturated fatty acids, 42-52% polyunsaturated fatty acids, and 18-24% monounsaturated fatty acids. Cottonseed oil is regarded as an Insecticide, as it is used to protect the trunks of apple trees from damage by the apple clearwing moth. Cottonseed oil possesses anti-inflammatory and cardioprotective properties. It also has extensive applications in many fields such as biofuels, animal husbandry, cosmetics, agriculture, and chemical industry .

HY-N0729D

Linoleic acid,suitable for cell culture

Biochemical Assay Reagents

Linoleic acid is a critical component of polyunsaturated fatty acids. Linoleic acid reduces GSH-PX and T-SOD activities. Linoleic acid functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid can cause acute oxidative damage to red blood cells, ultimately leading to partial acute anemia. Linoleic acid can be used in the research of skin diseases associated with linoleic acid deficiency .

HY-W089800

trans-2-Nonenal

trans-2-Nonen-1-al

Biochemical Assay Reagents

trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .

HY-115437

Methyl all-cis-7,10,13,16,19-docosapentaenoate	Biochemical Assay Reagents
Methyl all-cis-7,10,13,16,19-docosapentaenoate is a long-chain polyunsaturated omega-3 fatty acid esters.

HY-125139

omega-3 Arachidonic acid ethyl ester, in ethanol, 98%

ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%

Biochemical Assay Reagents

omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

HY-115369

Methyl (13Z,16Z,19Z)-docosatrienoate

Biochemical Assay Reagents

cis-13,16,19-Docosatrienoic acid methyl ester is an ester form of docosatrienoic acid, a rare omega-3 fatty acid not found in the normal phospholipid polyunsaturated fatty acid pool Easily detectable, it inhibits the binding of [3H]-LTB4 to porcine neutrophils at a concentration of 5 μM. Methyl docosatrienoate is more fat-soluble than the free acid and may be more desirable than the free acid in some formulations.

HY-120987

Ethyl stearidonate

Biochemical Assay Reagents

6,9,12,15-octadecatetraenoic acid (Glycerol α-monoelaidate) is a rare omega-3 series polyunsaturated fatty acid. In normal people, it accounts for less than 0.25% of serum phospholipid fatty acids. It is found in certain natural oils, such as echium and blackcurrant, and to the extent that these oils are incorporated into nutraceuticals, stearidonic acid can be an important polyunsaturated species in the human diet. Ethyl stearidonic acid, an ester of the free acid, is less water soluble but more suitable for formulating stearidonic acid-containing diets and dietary supplements.

HY-124187

Pinolenic acid ethyl ester

Ethyl pinolenate

Biochemical Assay Reagents

Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

HY-W127851

CLA

Cypridina luciferin analog

Biochemical Assay Reagents

CLA, or conjugated linoleic acid, is a polyunsaturated fatty acid that occurs naturally in a variety of animal products, such as meat and dairy. It has several potential benefits for human health, including the ability to reduce body fat mass, improve insulin sensitivity, and reduce inflammation. CLA has been extensively studied for its effects on weight loss and muscle growth, as well as its potential role in preventing chronic diseases such as heart disease and cancer. Additionally, it can be taken as a dietary supplement in capsule form.

HY-167808

cis-9,12-Hexadecadienoic acid

Biochemical Assay Reagents

Cis-9,12-Hexadecadienoic acid is a polyunsaturated fatty acid that has the activity of regulating the physical properties of cell membranes. The presence of Cis-9,12-Hexadecadienoic acid can enhance the fluidity and flexibility of cell membranes. Cis-9,12-Hexadecadienoic acid participates in a variety of physiological processes in the body, affecting cell signal transduction and membrane structure stability.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-109590

Arachidonic acid Maximum Cited Publications 55 Publications Verification Immunocytophyt	Structural Classification Human Gut Microbiota Metabolites Animals Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function .

HY-B0660

Eicosapentaenoic Acid 25+ Cited Publications EPA; Timnodonic acid	Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Histone Demethylase
Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .

HY-N0121

Sesamin 10+ Cited Publications	Neurological Disease Classification of Application Fields Anti-aging Sesamum indicum Linn. Lignans Phenylpropanoids Pedaliaceae Plants Disease Research Fields Source Classification	Stearoyl-CoA Desaturase (SCD)
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-113130

Eicosadienoic acid 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Eicosadienoic acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues .

HY-W013215

Adrenic acid 1 Publications Verification cis-7,10,13,16-Docosatetraenoic acid	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
Adrenic Acid (cis-7,10,13,16-Docosatetraenoic acid) is a naturally polyunsaturated fatty acid in the adrenal gland, brain, kidney, and vasculature. Adrenic Acid can regulate the vascular tone in arteries of the adrenal cortex. Adrenic Acid also is an inflammation enhancer in non-alcoholic fatty liver disease .

HY-21268

Methyl linolenate 1 Publications Verification Linolenic acid methyl ester	Structural Classification other families Classification of Application Fields Other Diseases Plants Disease Research Fields Lipid Source Classification	Environmental Pollutants Melatonin Receptor
Methyl linolenate is a polyunsaturated fattly acid (PUFA). Methyl linolenate has an anti-melanogenesis activity with an IC₅₀ of 60 μM. Methyl linolenate can also be used for studies of the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids .

HY-131897

1-Stearoyl-2-arachidonoyl-sn-glycerol 1 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Lipid Source Classification	PKC TRP Channel Endogenous Metabolite
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity .

HY-139066

Punicic acid 1 Publications Verification Trichosanic acid	Structural Classification Punica granatum L. Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Punicaceae Plants Disease Research Fields Source Classification	TNF Receptor GLUT Proteasome Tau Protein PKC
Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways .

HY-W089800

trans-2-Nonenal trans-2-Nonen-1-al	Source Classification	COX Lipoxygenase Apoptosis
trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .

HY-119546

Pinolenic acid PNLA	Pinaceae Ketones, Aldehydes, Acids Pinus koraiensis Siebold et Zuccarini Plants Source Classification	Free Fatty Acid Receptor
Pinolenic acid (PNLA) is a polyunsaturated fatty acid that can be isolated from Pinus orientalis and Pinus pinaster seed oil. Pinolenic acid has anti-inflammatory and lipid-lowering activities .

HY-113120

Stearidonic acid 6Z,9Z,12Z,15Z-Octadecatetraenoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Lipoxygenase
Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an orally active polyunsaturated fatty acid found in blackcurrant seed oil. Stearidonic acid can inhibit 5-lipoxygenase and reduce leukotriene and 5-HETE synthesis. Stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can be used for the research of metabolic disease .

HY-B0660R

Eicosapentaenoic Acid (Standard) EPA (Standard); Timnodonic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Histone Demethylase
Eicosapentaenoic Acid (Standard) is the analytical standard of Eicosapentaenoic Acid. This product is intended for research and analytical applications. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .

HY-N0121A

(-)-Sesamin	Classification of Application Fields Asarum forbesii Maxim. Lignans Other Diseases Phenylpropanoids Plants Disease Research Fields Aristolochiaceae Source Classification	Others
(-)-Sesamin isolated from Asarum forbesii Maxim, is an isomer of Sesamin. Sesamin is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis .

HY-N7140R

Gamma-Linolenic acid (Standard) 5+ Cited Publications γ-Linolenic acid (Standard)	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Labiatae Disease markers Endocrine diseases Metabolic Disease Tadehagi triquetrum (L.) Ohashi Plants Endogenous metabolite Disease Research Fields Source Classification	Reference Standards Endogenous Metabolite
Gamma-Linolenic acid (Standard) is the analytical standard of Gamma-Linolenic acid. This product is intended for research and analytical applications. Gamma-linolenic acid (γ-Linolenic acid) is an omega-6 (n-6), 18 carbon (18C-) polyunsaturated fatty acid (PUFA) extracted from Perilla frutescens. Gamma-linolenic acid supplements could restore needed PUFAs and mitigate the disease .

HY-116015

Dihomo-γ-Linolenic acid methyl ester	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
Dihomo-γ-Linolenic acid methyl ester is the methyl ester form of Dihomo-γ-Linolenic Acid (DGLA) (HY-A0143). Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is metabolized mainly through the cyclooxygenase (COX) pathway to the anti-inflammatory eicosanoid prostaglandin (PG) E1. Dihomo-γ-Linolenic acid has anti-inflammatory and antiproliferation effects .

HY-W011269

Eicosapentaenoic Acid sodium 25+ Cited Publications EPA sodium; Timnodonic acid sodium	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Histone Demethylase
Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation .

HY-134544

Calendic acid	Ketones, Aldehydes, Acids Plants Compositae Millettia usaramensis Taub. Source Classification	Apoptosis
Calendic acid (8(E),10(E),12(Z)-Octadecatrienoic acid) is a conjugated polyunsaturated fatty acid (PUFA) that can be isolated from C. officinalis seed oil. Calendic acid has anticancer activity .

HY-N0121R

Sesamin (Standard)	Structural Classification Sesamum indicum Linn. Lignans Phenylpropanoids Pedaliaceae Plants Source Classification	Stearoyl-CoA Desaturase (SCD) Reference Standards
Sesamin (Standard) is the analytical standard of Sesamin. This product is intended for research and analytical applications. Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-113130R

Eicosadienoic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Eicosadienoic acid (Standard) is the analytical standard of Eicosadienoic acid. This product is intended for research and analytical applications. Eicosadienoic acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues .

HY-N19728

5,9-Tetracosadienoic acid	Structural Classification Ketones, Aldehydes, Acids Marine natural products Sponge Source Classification	Biochemical Assay Reagents
5,9-Tetracosadienoic acid is a long-chain polyunsaturated fatty acid with a Δ ⁵, ⁹ unsaturated structure .

HY-N19806

8,11-Octadecadienoicacid, methyl ester	Structural Classification Natural Products Jatropha curcas Linn. Euphorbiaceae Plants Source Classification	Drug Derivative
8,11-Octadecadienoic acid, methyl ester is a polyunsaturated fatty acid methyl ester that can be extracted from castor seeds via direct ultrasonic transesterification .

HY-Z11709

13-Hydroxy-alpha-tocopherol	Structural Classification Natural Products Garcinia kola Heckel Guttiferae Plants Source Classification	Endogenous Metabolite
13-Hydroxy-alpha-tocopherol is a fat-soluble vitamin E derivative and anticancer agent with antioxidant and antiproliferative activities. 13-Hydroxy-alpha-tocopherol scavenges peroxyl free radicals and protects polyunsaturated fatty acids from oxidative damage. 13-Hydroxy-alpha-tocopherol not only inhibits the growth of glioma cancer cells, but its deficiency is also closely associated with recurrent miscarriage, embryonic growth retardation and death. Clinical observations show that the expression of 13-Hydroxy-alpha-tocopherol is downregulated in the follicular fluid of patients with recurrent miscarriage. 13-Hydroxy-alpha-tocopherol has important application potential in the research of recurrent miscarriage and glioma .

Species:	Human (3)
Tag:	His (2) Tag Free (1) GST (1)
Source:	Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704438

	ALOX5 Protein, Human (His) ALOX5; polyunsaturated fatty acid 5-lipoxygenase; Arachidonate 5-lipoxygenase (5-LO; 5-lipoxygenase; LOG5	Human	E. coli
	ALOX5 Protein, Human (His) is the recombinant human-derived ALOX5 protein, expressed by E. coli, with C-6*His tag.

HY-P74437

	15 Lipoxygenase 2 Protein, Human (sf9) polyunsaturated fatty acid lipoxygenase ALOX15B; 15-LOX-2; ALOX15B	Human	Sf9 insect cells
	15-lipoxygenase 2 (15-LOX2) is a nonheme iron-containing dioxygenase essential for the peroxidation of polyunsaturated fatty acids (PUFA). It exhibits peroxidase activity towards arachidonic acid and linoleic acid, producing bioactive lipid mediators. 15 Lipoxygenase 2 Protein, Human (sf9) is the recombinant human-derived 15 Lipoxygenase 2 protein, expressed by Sf9 insect cells, with tag free and additional two amino acids (Gly & Pro) at the N-terminus.

HY-P74436

	15 Lipoxygenase 2 Protein, Human (sf9, His-GST) polyunsaturated fatty acid lipoxygenase ALOX15B; 15-LOX-2; ALOX15B	Human	Sf9 insect cells
	15-lipoxygenase 2 (15-LOX2) is a nonheme iron-containing dioxygenase essential for the peroxidation of polyunsaturated fatty acids (PUFA). It exhibits peroxidase activity towards arachidonic acid and linoleic acid, producing bioactive lipid mediators. 15 Lipoxygenase 2 Protein, Human (sf9, His-GST) is the recombinant human-derived 15 Lipoxygenase 2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-117057S

Hexaenoic acid-d6

Hexaenoic acid-d₆ is deuterium labeled Hexaenoic acid. Very long chain polyunsaturated fatty acids (VLCPUFAs) are important components of ceramides and sphingomyelin and are present in retina, sperm, and brain. Tetratriaconta-16(Z),19(Z),22(Z),25(Z),28(Z),31(Z)-hexaenoic acid is a C34:6 VLCPUFA whose specific biological actions are largely unknown. This VLCPUFA, along with others, has been investigated for its role in activating protein kinase C .

HY-B0660S1

Eicosapentaenoic acid 1,2,3,4,5-13C5

Eicosapentaenoic acid 1,2,3,4,5- ¹³C₅ (EPA 1,2,3,4,5- ¹³C, FA 20:5- ¹³C₅) is ¹³C labeled Eicosapentaenoic Acid. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .

HY-21268S

Methyl linolenate-13C18
Methyl linolenate- ¹³C₁₈ is the ¹³C labeled Methyl linolenate . Methyl linolenate is a polyunsaturated fattly acid (PUFA). It is used in studies on the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids . The IC₅₀ is 60 uM .

HY-N0121S

Sesamin-d8
Sesamin-d8 is the deuterium labeled Sesamin (HY-N0121). Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-W744883

Methyl-d3 Linolenate
Methyl-d₃ Linolenate is the deuterium labeled Methyl linolenate (HY-21268). Methyl linolenate is a polyunsaturated fattly acid (PUFA). Methyl linolenate has an anti-melanogenesis activity with an IC₅₀ of 60 μM. Methyl linolenate can also be used for studies of the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids .

HY-131897S

1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol
1-Stearoyl-2-Arachidonoyl-d₈-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity .

HY-122129S

Dotriaconta-14,17,20,23,26,29-hexaenoic acid-d6

Dotriaconta-14,17,20,23,26,29-hexaenoic acid-d₆ is deuterium labeled Dotriaconta-14,17,20,23,26,29-hexaenoic acid. Very long chain polyunsaturated fatty acids (VLCPUFA) are present in retina, sperm, and brain. Though little is known of their biosynthesis or functional roles in these tissues, recent studies using the elongation of very long-chain FA-4 protein suggest a unique role for VLCPUFA in retinal development and macular degeneration. Dotriaconta-14,17,20,23,26,29-hexaenoic acid is a C32:6 VLCPUFA whose specific biological actions are largely unknown, but are thought to involve normal photoreceptor cell function in the retina .

HY-109590S4

Arachidonic acid-13C5

Arachidonic acid- ¹³C₅ (Immunocytophyt- ¹³C₅) is the ¹³C-labeled Arachidonic acid (HY-109590). Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function .

HY-B0660S2

Eicosapentaenoic acid-d10

Eicosapentaenoic acid-d₁₀ (EPA-d₁₀) is the deuterium labeled Eicosapentaenoic acid (HY-B0660). Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .

Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (2) human (1)
Application:	IHC-P (2) ICC/IF (1) IF-Tissue (1) IP (1) WB (1) ELISA (1)
Isotype:	IgG (2) IgG2b (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81346

	15 Lipoxygenase 1/ALOX15 Antibody (YA1091) LOG15; LOG15; polyunsaturated fatty acid lipoxygenase ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15	IHC-P	Human
	15 Lipoxygenase 1/ALOX15 Antibody (YA1091) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 15 Lipoxygenase 1/ALOX15 .

HY-P81346A

	15 Lipoxygenase 1/ALOX15 Antibody (YA1091)(PBS only) LOG15; LOG15; polyunsaturated fatty acid lipoxygenase ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15	IHC-P	Human
	15 Lipoxygenase 1/ALOX15 Antibody (YA1091) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 15 Lipoxygenase 1/ALOX15 .

HY-P89640

	15-LO2 Antibody (YA8984) polyunsaturated fatty acid lipoxygenase ALOX15B, 15-lipoxygenase 2, Arachidonate 15-lipoxygenase B, Arachidonate 15-lipoxygenase type II, Linoleate 13-lipoxygenase 15-LOb, 15-LOX-2, 15-LOX-B, ALOX15B	WB, ICC/IF, IF-Tissue, IP, ELISA	human
	15-LO2 Antibody (YA8984) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to 15-LO2.

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Cat. No.	Product Name		Classification

HY-17639

Navamepent RX-10045		Alkynes
Navamepent is an analog of naturally occurring resolvin E1 (a major dietary omega-3 polyunsaturated fatty-acid metabolite) with potent anti-inflammatory and cell survival benefits. Navamepent is highly effective against dry eye and goblet cell loss thereby accelerating tear production. Also, Navamepent can reduce corneal inflammation, epithelial damage, and accelerate corneal tissue repair. In addition, Navamepent can inhibit the release of several key proinflammatory mediators from corneal epithelial cells. Navamepent is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-Y1887

Cottonseed oil		Solvents
Cottonseed oil is an edible oil extracted from the seeds of cotton (Gossypium hirsutum). Its fatty acid composition includes 26-35% saturated fatty acids, 42-52% polyunsaturated fatty acids, and 18-24% monounsaturated fatty acids. Cottonseed oil is regarded as an Insecticide, as it is used to protect the trunks of apple trees from damage by the apple clearwing moth. Cottonseed oil possesses anti-inflammatory and cardioprotective properties. It also has extensive applications in many fields such as biofuels, animal husbandry, cosmetics, agriculture, and chemical industry .

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polyunsaturated fatty acid chloride

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