141 Results for "

programmed cell death

" in MedChemExpress (MCE) Product Catalog:
Products (141)

141 Results for "programmed cell death" in MCE Product Catalog:

35
Pembrolizumab
Pembrolizumab
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35 Publications Verification
Art. -Nr.: HY-P9902
CAS. Nr.: 1374853-91-4
Synonyms: MK-3475; Lambrolizumab

Target:  

PD-1/PD-L1

Forschungsgebiete:  

Cancer

Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy.
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24
Nivolumab
Nivolumab
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24 Cited Publications
Art. -Nr.: HY-P9903
CAS. Nr.: 946414-94-4
Synonyms: BMS-936558; ONO-4538; MDX-1106

Target:  

PD-1/PD-L1

Forschungsgebiete:  

Infection Cancer

Nivolumab is a programmed death receptor-1 (PD-1) blocking human IgG4 antibody to treat advanced (metastatic) non-small cell lung cancer.
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9
PD-L1 Protein, Human (HEK293)
PD-L1 Protein, Human (HEK293)
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9 Cited Publications
Art. -Nr.: HY-P73361
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: programmed cell death 1 ligand 1; PD-L1; B7-H1; CD274; PDL1
Species:  
Human
Source:  
HEK293
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5
Concanavalin A
Concanavalin A
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5 Cited Publications
Art. -Nr.: HY-P2149
CAS. Nr.: 11028-71-0
Concanavalin A can be coupled to agarose to form Concanavalin A (agarose) (HY-P2149A). Concanavalin A (ConA) is a selective, competitive binding agent that targets specific carbohydrate structures containing glucose and mannose; it acts as a mitogen and exhibits varying degrees of cytotoxicity, hepatotoxicity, and teratogenicity. Concanavalin A is also utilized for in vivo blood glucose monitoring in the context of diabetes .
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4
PD-1 Antibody(YA3401)
PD-1 Antibody(YA3401)
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4 Cited Publications
Art. -Nr.: HY-P81169A
Synonyms: programmed cell death protein 1; CD279; CD279 antigen; hPD 1; hPD-1; hSLE1; PD 1; PD1; PDCD 1; PDCD1; PDCD1_HUMAN; programmed cell death 1; Protein PD 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2.

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF, FC

Reactivity:  

Human

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4
Panaxadiol
Panaxadiol
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4 Cited Publications
Art. -Nr.: HY-N0596
CAS. Nr.: 19666-76-3
Synonyms: 20(R)-Panaxadiol
Category:  

Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Araliaceae Cancer

Target:  

PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT

Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities .
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3
Tislelizumab
Tislelizumab
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3 Cited Publications
Art. -Nr.: HY-P99052
CAS. Nr.: 1858168-59-8
Synonyms: BGB-A317

Target:  

PD-1/PD-L1

Forschungsgebiete:  

Inflammation/Immunology Cancer

Tislelizumab is a monoclonal antibody that specifically binds to programmed cell death receptor 1 (PD-1), blocking its interaction with programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2). Tislelizumab can reactivate immune cells such as T lymphocytes and enhance anti-tumor activity. Tislelizumab can be used for the research of a variety of tumors including typical Hodgkin's lymphoma, urothelial carcinoma, non-small cell lung cancer and hepatocellular carcinoma .
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3
PD-1 Protein, Human (HEK293, Fc, solution)
PD-1 Protein, Human (HEK293, Fc, solution)
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3 Cited Publications
Art. -Nr.: HY-P73344
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD279; hPD-1; PDCD1; programmed cell death 1; SLEB2
Species:  
Human
Source:  
HEK293
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2
PD-L1 Protein, Mouse (HEK293, His)
PD-L1 Protein, Mouse (HEK293, His)
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2 Cited Publications
Art. -Nr.: HY-P70632
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: programmed cell death 1 ligand 1Cd274; programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; programmed death ligand 1; B7 homolog 1; B7-H1; CD274
Species:  
Mouse
Source:  
HEK293
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2
Gypenoside XLIX
Gypenoside XLIX
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2 Cited Publications
Art. -Nr.: HY-N1990
CAS. Nr.: 94987-08-3
Category:  

Cardiovascular Disease Triterpenes Terpenoids Cucurbitaceae Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino

Target:  

PPAR Sirtuin Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Apoptosis Pyroptosis Autophagy

Gypenoside XLIX is a multifunctional bioactive compound that can be isolated from Gynostemma pentaphyllum, with a Ka value of 1.58 μM for its binding to SIRT1. Gypenoside XLIX acts as a PPAR-α agonist. It inhibits the activation of TLR4-mediated NF-κB signaling pathway by activating the Sirt1/Nrf2 signaling pathway, reduces ROS accumulation, and alleviates hepatic inflammatory injury in mice with sepsis-induced liver disease. Gypenoside XLIX targets SIRT1 to block YAP-NLRP3 activation and improve sepsis-induced cardiomyopathy. Gypenoside XLIX inhibits apoptosis (Apoptosis), pyroptosis (Pyroptosis), autophagy (Autophagy), lipid peroxidation, pro-inflammatory cytokines and anti-inflammatory cytokines. Gypenoside XLIX alleviates sepsis-induced splenic injury by inhibiting inflammation and oxidative stress, and mitigates sepsis-associated encephalopathy by targeting PPAR-α. Gypenoside XLIX prevents acute kidney injury by inhibiting IGFBP7/IGF1R-mediated programmed cell death and inflammation. Gypenoside XLIX inhibits the expression and activity of vascular cell adhesion molecule-1 in cytokine-induced human endothelial cells. Gypenoside XLIX is applicable to research related to acute liver injury, lung injury, cardiomyopathy, acute splenic injury, sepsis-associated encephalopathy, acute kidney injury, atherosclerosis and chronic inflammation .
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1
PD-1 Protein, Mouse (HEK293, His-Fc)
PD-1 Protein, Mouse (HEK293, His-Fc)
0 Images
1 Cited Publications
Art. -Nr.: HY-P73724
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: programmed cell death protein 1; PD1; CD279; PDCD1
Species:  
Mouse
Source:  
HEK293
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1
PD-1 Protein, Mouse (HEK293, Fc)
PD-1 Protein, Mouse (HEK293, Fc)
0 Images
1 Cited Publications
Art. -Nr.: HY-P70639
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: programmed cell death protein 1; PD-1; CD279; Pdcd1; mPD-1
Species:  
Mouse
Source:  
HEK293
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1
PD-L1 Antibody (YA4674)
PD-L1 Antibody (YA4674)
0 Images
1 Cited Publications
Art. -Nr.: HY-P84982
Synonyms: programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; programmed death ligand 1; B7 homolog 1; B7-H1; CD antigen CD274; CD274 nanobody; PD-L1 nanobody;

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human

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1
RSM3
RSM3
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1 Cited Publications
Art. -Nr.: HY-P10387
Target:  

METTL3 Apoptosis MDM-2/p53 NF-κB Caspase

Forschungsgebiete:  

Cancer

RSM3 is a METTL3-METTL14 complex inhibitor with a Kd of 3.10 μM for the METTL3-METTL14 complex. RSM3 reduces the m 6A modification level of SLC31A1 and the global RNA methylation level. RSM3 upregulates programmed cell death-related genes, enhances cell apoptosis, inhibits pro-cancer signals and suppresses tumor growth. RSM3 is applicable to the research of preeclampsia and cancer .
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1
RSM3 TFA
RSM3 TFA
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1 Cited Publications
Art. -Nr.: HY-P10387A
Target:  

METTL3 Apoptosis

Forschungsgebiete:  

Cancer

RSM3 TFA is a METTL3-METTL14 complex inhibitor with a Kd of 3.10 μM for the METTL3-METTL14 complex. RSM3 TFA reduces the m 6A modification level of SLC31A1 and the global RNA methylation level. RSM3 TFA upregulates programmed cell death-related genes, enhances cell apoptosis, inhibits pro-cancer signals and suppresses tumor growth. RSM3 TFA is applicable to the research of preeclampsia and cancer .
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Cathepsin B, Bovine spleen
Cathepsin B, Bovine spleen
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Art. -Nr.: HY-P2780
CAS. Nr.: 9047-22-7
Target:  

Apoptosis Ferroptosis Autophagy Necroptosis

Forschungsgebiete:  

Others Cancer

Cathepsin B, Bovine spleen is a cysteine protease and is involved in multiple kinds of programmed cell death (including apoptosis, pyroptosis, ferroptosis, necroptosis, and autophagic cell death) .
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Fidasimtamab
Fidasimtamab
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Art. -Nr.: HY-P99618
CAS. Nr.: 2377419-89-9
Synonyms: IBI-315; BH2950

Target:  

EGFR PD-1/PD-L1

Forschungsgebiete:  

Cancer

Fidasimtamab is a bispecific antibody targeting human epidermal growth factor receptor 2 (Her2) and programmed death protein 1 (PD-1), with a Ka of 3.55e-10 M for human Her2 and a Ka of 1.17e-9 M for human PD-1. Fidasimtamab cross-links Her2-positive tumor cells with PD-1-positive T cells to form immune synapses, blocks PD-1-ligand interactions, preserves antibody-dependent cellular cytotoxicity, induces gasdermin B (GSDMB)-mediated pyroptosis, and activates T cells. Fidasimtamab is applicable to relevant research on Her2-positive gastric cancer .
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Bintrafusp alfa
Bintrafusp alfa
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Art. -Nr.: HY-P99480
CAS. Nr.: 1918149-01-5
Synonyms: M7824; MSB0011359C

Target:  

TGF-β Receptor

Forschungsgebiete:  

Cancer

Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer .
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Cemiplimab
Cemiplimab
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Art. -Nr.: HY-P99203
CAS. Nr.: 1801342-60-8
Synonyms: REGN-2810; SAR-439684

Target:  

PD-1/PD-L1

Forschungsgebiete:  

Cancer

Cemiplimab (Anti-Human PD-1) is a high-affinity programmed death receptor-1 (PD-1) monoclonal IgG4 antibody that blocks PD-1/PD-L1-mediated T-cell suppression. Cemiplimab is commonly used in squamous cell skin cancer research .
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Bersanlimab
Bersanlimab
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Art. -Nr.: HY-P99473
CAS. Nr.: 1987854-08-9
Synonyms: BI-505

Target:  

Integrin

Forschungsgebiete:  

Cancer

Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects .
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