1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. Snail/HDAC-IN-1

Snail/HDAC-IN-1 

Cat. No.: HY-144315
Handling Instructions

Snail/HDAC-IN-1 is a potent Snail/HDAC dual target inhibitor. Snail/HDAC-IN-1 displays potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM and potent inhibition against Snail with a Kd of 0.18 μM. Snail/HDAC-IN-1 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis.

For research use only. We do not sell to patients.

Snail/HDAC-IN-1 Chemical Structure

Snail/HDAC-IN-1 Chemical Structure

CAS No. : 2415281-52-4

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Description

Snail/HDAC-IN-1 is a potent Snail/HDAC dual target inhibitor. Snail/HDAC-IN-1 displays potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM and potent inhibition against Snail with a Kd of 0.18 μM. Snail/HDAC-IN-1 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis[1].

IC50 & Target[1]

HDAC1

0.405 μM (IC50)

Snail

0.18 μM (Kd)

In Vitro

Snail/HDAC-IN-1 (compound 9n) shows antiproliferative activity in HCT-116 cell lines with an IC50 of 0.0751 μM. Snail/HDAC-IN-1 shows a good inhibitory effect on NCI–H522 (GI50=0.0488 μM), MDA-MB-435 (GI50=0.0361 μM), and MCF7 (GI50=0.0518 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

488.54

Formula

C24H21FN8OS

CAS No.
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Product Name:
Snail/HDAC-IN-1
Cat. No.:
HY-144315
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