KH-259
KH-259 (compound 1) is a potent, selective and CNS-penetrant HDAC6 inhibitor, with an IC50 of 0.26 μM. KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain. KH-259 can be used for neurodegenerative diseases research.
For research use only. We do not sell to patients.
- CAS No.: 3023019-93-1
- Formula: C20H25N3O2
- Molecular Weight:339.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC6 0.26 ± 0.2 μM (IC50) |
HDAC1 6.7 ± 0.14 μM (IC50) |
HDAC4 12.3 ± 0.4 μM (IC50) |
KH-259 (compound 1) exhibits acceptable metabolic stability in both mouse and human liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3023019-93-1
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Molecular Weight 339.43
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Formula C20H25N3O2
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SMILES
CC(N1CCN(CC2=CC=C(C(NO)=O)C=C2)CC1)C3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KH-259 Related Classifications
HY-150503 Related Classifications
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