Cat. No.: HY-B0480A

Brompheniramine

(Synonyms: (±)-Brompheniramine)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Brompheniramine ((±)-Brompheniramine) is a potent and orally active antihistamine of the alkylamine class. Brompheniramine is a selective histamine H1 receptor antagonist with a K_d of 6.06 nM. Brompheniramine can block the hERG channels, calcium channels, and sodium channels with IC₅₀s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research.

For research use only. We do not sell to patients.

Purity: 99.82%
CAS No.: 86-22-6
Formula: C₁₆H₁₉BrN₂
Molecular Weight:319.24

Storage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Brompheniramine Chemical Structure

CAS No.: 86-22-6

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

H₁ Receptor

All Histamine Receptor Isoforms :

All mAChR Isoforms :

All Sodium Channel Isoforms :

All Calcium Channel Isoforms :

In Vitro

Brompheniramine (0.1-100 μM) blocks hERG K⁺ channels expressed in CHO cells in a concentration-dependent manner with an IC₅₀ of 0.90±0.14 μM, and reduced peak tail current amplitude measured at -60 mV (cells are depolarized for 2 s to +20 mV from a holding potential of -80 mV followed by a 3s repolarization back to -60 mV)^[3].
Brompheniramine (1, 10 and 100 μM) significantly shortens the APD₅₀ and depresses the plateau phase on the action potential in guinea pig papillary muscle, as well as slightly prolongs the APD₉₀ in guinea pig papillary muscle at 10 and 100 μM^[3].
Brompheniramine (0.1-100 μM) inhibit the amplitude of the Ca²⁺ channel currents in rat ventricular myocytes by 14.1±1.1, 31.1±5.8, 38.0±3.8 and 90.2±3.7% at 0.1, 1, 10 and 100 μM, respectively^[3].
Brompheniramine blocks muscarinic cholinergic receptors in human chinese hamster ovary (CHO) cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Brompheniramine (0.3-3 μM; SC, single dosage) induces cutaneous analgesia in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats^[1]
Dosage:

0.3, 0.6, 1.1, 1.5 and 3.0  μM
Administration:

SC, single dosage
Result:

Provoked cutaneous analgesia in a dose-dependent manner, with an EC₅₀ value of 0.66 μM, and induced prolonged analgesic duration.

Chemical Information

CAS No. 86-22-6
Appearance Liquid
Molecular Weight 319.24
Formula C₁₆H₁₉BrN₂
Color Colorless to light yellow
SMILES

CN(C)CCC(C1=CC=C(Br)C=C1)C2=CC=CC=N2
Synonyms

(±)-Brompheniramine
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Biomaterials

Cellhesion VP enhances the immunomodulating potential of human mesenchymal stem cell-derived extracellular vesicles. [Abstract]

2021 Apr:271:120742. PMID: 33706111
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (313.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1324 mL

15.6622 mL

31.3244 mL

5 mM

0.6265 mL

3.1324 mL

6.2649 mL

10 mM

0.3132 mL

1.5662 mL

3.1324 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chong-Chi Chiu, et al. Subcutaneous brompheniramine for cutaneous analgesia in rats. Eur J Pharmacol. 2019 Oct 5;860:172544. [Content Brief]

[2]. B Cusack, et al. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. [Content Brief]

[3]. Shin WH, Kim KS, Kim EJ. Electrophysiological effects of brompheniramine on cardiac ion channels and action potential. Pharmacol Res. 2006 Dec;54(6):414-20. [Content Brief]

[4]. Yasuda SU, Yasuda RP. Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic cholinergic receptor subtypes. Pharmacotherapy. 1999 Apr;19(4):447-51. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1324 mL	15.6622 mL	31.3244 mL	78.3110 mL
	5 mM	0.6265 mL	3.1324 mL	6.2649 mL	15.6622 mL
	10 mM	0.3132 mL	1.5662 mL	3.1324 mL	7.8311 mL
	15 mM	0.2088 mL	1.0441 mL	2.0883 mL	5.2207 mL
	20 mM	0.1566 mL	0.7831 mL	1.5662 mL	3.9155 mL
	25 mM	0.1253 mL	0.6265 mL	1.2530 mL	3.1324 mL
	30 mM	0.1044 mL	0.5221 mL	1.0441 mL	2.6104 mL
	40 mM	0.0783 mL	0.3916 mL	0.7831 mL	1.9578 mL
	50 mM	0.0626 mL	0.3132 mL	0.6265 mL	1.5662 mL
	60 mM	0.0522 mL	0.2610 mL	0.5221 mL	1.3052 mL
	80 mM	0.0392 mL	0.1958 mL	0.3916 mL	0.9789 mL
	100 mM	0.0313 mL	0.1566 mL	0.3132 mL	0.7831 mL

Keywords

Brompheniramine

2 Cited Publications

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Brompheniramine

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Publications Citing Use of MedChemExpress (MCE) Brompheniramine

All Histamine Receptor Isoforms

All mAChR Isoforms

All Sodium Channel Isoforms

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Brompheniramine Related Classifications

HY-B0480A Related Classifications