β-1,3-Glucan
Based on 2 publication(s) in Google Scholar
β-1,3-Glucan (β Glucan) is an orally active polysaccharide composed of glucose polymers. β-1,3-Glucan increase the activity of IKKβ kinase, enhances the production of nitric oxide. β-1,3-Glucan improves resistance to Vibrio harveyi infection. β-1,3-Glucan enhances immune response, promotes blood pressure recovery, reduces lung, kidney and liver damage, inhibits the growth of syngeneic tumors.
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- Pureté: 98.18%
- CAS No.: 9051-97-2
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) β-1,3-Glucan
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Activité biologique
Description
IC50 & Target
[8]|
IKKβ |
In Vitro
β-1,3-Glucan (PGG-Glucan; 0.1-3 μg/mL; 3 h) can enhance the oxidative burst response of leukocytes to soluble and particulate activators and their microbicidal activity in a dose-dependent manner[1].
β-1,3-Glucan (0.5-5 mg/mL; 3 days) can significantly promote proliferation of L-929 fibroblasts[3].
β-1,3-Glucan can increase the activity of IKKβ kinase in the murine monocytic cell line J774a.1, and also enhance the production of nitric oxide and superoxide in murine peritoneal macrophages[8].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
β-1,3-Glucan (40-160 mg/kg; p.o.; 5-10 days) enhances the proliferative response of spleen cells to mitogens, enhances the activity of natural killer cells and the lysosomal enzyme activity of peritoneal macrophages, and also inhibits the growth of syngeneic tumors in mice[4].
β-1,3-Glucan (20 mg/kg/day, p.o.; 2 mg/kg/day, s.c.; oral administration for 14 days, subcutaneous injection for 3 days) can promote the recovery of blood pressure, reduce kidney and liver injuries, and also regulate cytokine levels in a rat model of endotoxemia[5].
β-1,3-Glucan (2 mg/kg; i.m.; injected immediately after surgery and at 4 h after surgery) can improve the survival rate, reduce acute lung injury, inhibit the release of pro-inflammatory cytokines in a rat model of sepsis induced by cecal ligation and puncture (CLP)[6].
β-1,3-Glucan (250-1000 mg/kg; p.o.; once a day; 18 days) prevents myelosuppression and splenomegaly caused by tumors in tumor-bearing mice[7].
β-1,3-Glucan (150 mg/kg; p.o.; once daily; 7 days) can reverse the immunosuppression mediated by Aflatoxin B1 (HY-N6615), increase the percentages of lymphocyte subsets and the levels of multiple cytokines in the male adult Balb/c mouse model[8].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male BALB/c mice, 6-8 weeks old, Ehrlich ascites tumour (EAT)-bearing model[7]
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Dosage:250 mg/kg, 500 mg/kg, 1000 mg/kg
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Administration:Oral gavage, once a day for 18 days
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Result:Significantly prolonged the lifespan of EAT-bearing mice.
Prevented myelosuppression and splenomegaly by increasing the number of granulocyte-macrophage progenitors in the bone marrow and increasing colony-stimulating activity in the serum.
Restored the ability of bone marrow stromal cells from tumor - bearing mice to display myeloid progenitors in long-term bone marrow cultures.
Upregulated the production of interleukin (IL)-6 and IL-1α by these cells.
Restored natural killer cell activity.
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 9051-97-2
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Appearance Solid
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Color Off-white to light yellow
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SMILES
[beta Glucan]
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Synonyms
β Glucan
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
Solvant et solubilité
In Vitro:
H2O : 40 mg/mL (ultrasonic and adjust pH to 12 with 1 M NaOH)
DMSO : 5 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Pureté et documentation
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Fiche technique (287 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Wakshull E, et al. PGG-glucan, a soluble beta-(1,3)-glucan, enhances the oxidative burst response, microbicidal activity, and activates an NF-kappa B-like factor in human PMN: evidence for a glycosphingolipid beta-(1,3)-glucan receptor. Immunopharmacology. 1999 Feb;41(2):89-107. [Content Brief]
[2]. Ai Q, et al. Effects of dietary beta-1, 3 glucan on innate immune response of large yellow croaker, Pseudosciaena crocea. Fish Shellfish Immunol. 2007 Apr;22(4):394-402. [Content Brief]
[5]. Sandvik A, et al. Oral and systemic administration of beta-glucan protects against lipopolysaccharide-induced shock and organ injury in rats. Clin Exp Immunol. 2007 Apr;148(1):168-77. [Content Brief]
[6]. Bedirli A, et al. Beta-glucan attenuates inflammatory cytokine release and prevents acute lung injury in an experimental model of sepsis. Shock. 2007 Apr;27(4):397-401. [Content Brief]
[7]. Torello CO, et al. β-1,3-Glucan given orally modulates immunomyelopoietic activity and enhances the resistance of tumour-bearing mice. Clin Exp Pharmacol Physiol. 2012 Mar;39(3):209-17. [Content Brief]
[8]. Bakheet SA, et al. β-1,3-Glucan reverses aflatoxin B1-mediated suppression of immune responses in mice. Life Sci. 2016 May 1;152:1-13. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
β-1,3-Glucan Related Classifications
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