Cardiovascular Disease

Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of angiotensin II receptor (IC₅₀=48.2 μM). Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is a quinolone alkaloid from Evodia rutaecarpa.

Purpurogallin (Standard) is the analytical standard of Purpurogallin. This product is intended for research and analytical applications. Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC50 of 0.2 μM. Purpurogallin has antioxidant and anti-inflammatory effects.

Carboxyamidotriazole (Orotate) (Standard) is the analytical standard of Carboxyamidotriazole (Orotate). This product is intended for research and analytical applications. Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate shows anti-tumor, anti-inflammatory and antiangiogenic effects.

TPT-260 (TPU260), a thiophene thiourea derivative, is a retromer complex stabilizer against thermal denaturation (K_d = ~5 µM). TPT-260 increases the levels of retromer proteins, shifts amyloid-precursor protein (APP) away from the endosome, and decreases the pathogenic processing of APP. TPT-260 inhibits TLR4 upregulation, IKKβ phosphorylation, NF-κB p65 nuclear translocation, and NLRP3 inflammasome formation. TPT-260 improves retromer-mediated cargo trafficking, reduces brain infarct area, and decreases amyloid plaque deposition. TPT-260 exhibits minimal cytotoxicity to primary microglia at tested concentrations. TPT-260 can be used for the research of inflammatory bowel disease, ischemic stroke and Alzheimer's disease.

Argatroban (monohydrate) (Standard) is the analytical standard of Argatroban (monohydrate). This product is intended for research and analytical applications. Argatroban (monohydrate) (MD-805 (monohydrate)) is a direct, selective thrombin inhibitor.

Flavone (Standard) is the analytical standard of Flavone. This product is intended for research and analytical applications. Flavone is an endogenous metabolite.

NS5806 (Standard) is the analytical standard of NS5806 (HY-108588). This product is intended for research and analytical applications. NS5806, a potent potassium current activator, increases KV4.3/KChIP2 peak current amplitudes with an EC₅₀ of 5.3 μM. NS5806 slows KV4.3 and KV4.2 current dacay in channel complexes containing KChIP2.

5-Hydroxytryptamine creatinine sulfate monohydrate (Standard) is the analytical standard of 5-Hydroxytryptamine creatinine sulfate monohydrate (HY-W010973). This product is intended for research and analytical applications. 5-Hydroxytryptamine creatinine sulfate monohydrate is a 5-HT receptor agonist and amine oxidase substrate that acts through multiple physiological responses, including induction of vasoconstriction, pressor effects, acceleration of platelet potassium exchange, and endothelium-dependent relaxation, and can serve as a radiolabeled substrate for organelle uptake assays. 5-Hydroxytryptamine creatinine sulfate monohydrate can be used in research on burns, tourniquet and botulinum shock.

Tetramisole hydrochloride (Standard) is the analytical standard of Tetramisole (hydrochloride). This product is intended for research and analytical applications. Tetramisole hydrochloride is an orally active, selective inward rectifier potassium channel agonist with an EC₅₀ of approximately 30 μM for the Kir2.1 subunit. Tetramisole hydrochloride is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole hydrochloride promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole hydrochloride can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure.

ONO-7300243 (Standard) is the analytical standard of ONO-7300243 (HY-100882). This product is intended for research and analytical applications. ONO-7300243 is a novel, potent lysophosphatidic acid receptor 1 (LPA1) antagonist with IC50 of 0.16 μM.

Travoprost-d₇ (Fluprostenol isopropyl ester-d₇) is deuterium labeled Travoprost. Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension.

Bet-in-24 (example 2) is a bromodomain and extra-terminal (BET) inhibitor. BET-IN-24 can be used in the study of virology, heart failure, inflammation, central nervous system (CNS) diseases and many cancers

QCC374 is a selective agonist of IP.

WIZ degrader 7 (Example 16) is a WIZ molecular glue degrader with an IC₅₀ value of < 0.01 μM. WIZ degrader 7 can be used to investigate sickle cell disease (SCD) and thalassemia.

11-Keto-9(E),12(E)-octadecadienoic acid has enhanced endothelial cell fibrinolytic activity.

SB-633825 (Standard) is the analytical standard of SB-633825 (HY-108333). This product is intended for research and analytical applications. SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC₅₀s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis.

Pimobendan hydrochloride (UD-CG115 hydrochloride) is a selective inhibitor of PDE3 with IC₅₀ of 0.32 μM.

PX-478 (Standard) is the analytical standard of PX-478 (HY-10231). This product is intended for research and analytical applications. PX-478 is a multifunctional HIF-1α inhibitor with properties including radiosensitization, autophagy activation, and lipid accumulation inhibition. PX-478 also blocks hypoxia-induced VEGF production and regulates β-cell phenotypes under hypoxic conditions. PX-478 induces cell cycle arrest and DNA damage, restores autophagic function, reduces foam cell formation, and maintains glucose homeostasis. PX-478 is widely used in research on related diseases such as human tumors (e.g., prostate cancer), type 2 diabetes, and atherosclerosis.

Droxidopa-¹³C₆ (L-DOPS-¹³C₆) is ¹³C labeled Droxidopa. Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder).

Louisianin D is a non-steroidal growth inhibitor of Testosterone-responsive SC 115 cells. Louisianin D potently suppresses the tube formation of cultured vascular endothelical cells in vitro.