5-HT Receptor
Serotonin Receptor; 5-hydroxytryptamine Receptor
5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.
5-HT Receptor Isoform Specific Products
-
5-HT Receptor
(575)
View all products
-
5-HT1 Receptor
(454)
View all products
-
5-HT2 Receptor
(489)
View all products
-
5-HT3 Receptor
(35)
View all products
-
5-HT4 Receptor
(19)
View all products
-
5-HT5 Receptor
(14)
View all products
-
5-HT6 Receptor
(86)
View all products
-
5-HT7 Receptor
(89)
View all products
All Product Categories
-
5-HT Receptor Inhibitors
(203)
View all products
-
5-HT Receptor Agonists
(556)
View all products
-
5-HT Receptor Antagonists
(690)
View all products
-
5-HT Receptor Activators
(19)
View all products
-
5-HT Receptor Modulators
(96)
View all products
-
5-HT Receptor Inducers
(2)
View all products
-
5-HT Receptor Controls
(20)
View all products
-
5-HT Receptor Ligands
(33)
View all products
-
5-HT Receptor Related Products (1770)
Related Products (1770)
-
Antibodies (1)
-
Related Compound Screening Libraries (1)
-
5-HT Receptor Isoform Comparison
-
IS-159
0 ImagesCat. No.: HY-106124CAS No.: 133790-13-3IS-159 is a potent serotonin 5-HT1 agonist. IS-159 has the potential for the research of migraine.
-
Desvenlafaxine fumarate
0 ImagesCat. No.: HY-B0602BCAS No.: 93414-04-1Synonyms: O-Desmethylvenlafaxine fumarateDesvenlafaxine (O-Desmethylvenlafaxine) fumarate is a selective serotonin and norepinephrine reuptake inhibitor. Desvenlafaxine (O-Desmethylvenlafaxine) fumarate is the major metabolite of the antidepressant venlafaxine. Desvenlafaxine (O-Desmethylvenlafaxine) fumarate has the potential for the research of depression and related disorders and diseases (extracted from patent WO2009049354A1).
-
Cilansetron
0 ImagesCilansetron is a 5-HT3 receptor antagonist. Cilansetron can be used in studies of irritable bowel syndrome.
-
Nefazodone hydrochloride (Standard)
0 ImagesSynonyms: BMY-13754 (Standard); MJ-13754-1 (Standard)Nefazodone (hydrochloride) (Standard) is the analytical standard of Nefazodone (hydrochloride). This product is intended for research and analytical applications. Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity.
-
Flesinoxan (Standard)
0 ImagesCat. No.: HY-121653RCAS No.: 98206-10-1Flesinoxan (Standard) is the analytical standard of Flesinoxan. This product is intended for research and analytical applications. Flesinoxan is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects.
-
4-Bromo-2,5-DMMA
0 ImagesCat. No.: HY-168747CAS No.: 155638-80-54-Bromo-2,5-DMMA (Compound 2) has affinity for 5-HT2 binding sites. 4-Bromo-2,5-DMMA has an ED50 of 0.82 mg/kg in the rat discrimination tests.
-
Trimipramine-d3 maleate
0 ImagesCat. No.: HY-B1213SCAS No.: 1185245-93-5Trimipramine-d3 (maleate) is the deuterium labeled Trimipramine maleate. Trimipramine maleate is a 5-HT receptor antagonist, with pKis of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively.
-
SB-236057
0 ImagesCat. No.: HY-116603CAS No.: 180083-49-2SB-236057 is an inverse agonist of the 5-HT1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis.
-
SB-224289 hydrochloride (Standard)
0 ImagesCat. No.: HY-101105ARCAS No.: 180084-26-8Synonyms: SB-224289A (Standard)SB-224289 (hydrochloride) (Standard) is the analytical standard of SB-224289 (hydrochloride) (HY-101105A). This product is intended for research and analytical applications. SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect.
-
Temanogrel (Standard)
0 ImagesCat. No.: HY-10560RCAS No.: 887936-68-7Synonyms: APD791 (Standard)Temanogrel (Standard) is the analytical standard of Temanogrel. This product is intended for research and analytical applications. Temanogrel is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM.
-
8-OH-DPAT (Standard)
0 ImagesSynonyms: 8-Hydroxy-DPAT (Standard)8-OH-DPAT (Standard) is the analytical standard of 8-OH-DPAT. This product is intended for research and analytical applications. 8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).
-
Alosetron ((Z)-2-butenedioate)
0 ImagesCat. No.: HY-70050BCAS No.: 122852-43-1Synonyms: GR 68755 ((Z)-2-butenedioate); GR 68755X ((Z)-2-butenedioate)Alosetron (GR 68755) (Z)-2-butenedioate is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron (Z)-2-butenedioate is used for the research of irritable bowel syndrome (IBS). Alosetron (Z)-2-butenedioate blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron (Z)-2-butenedioate attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.
-
MCI-225 (dehydratase)
0 ImagesCat. No.: HY-123498CAS No.: 99487-26-0Synonyms: DDP 225 (dehydratase)MCI-225 dehydratase is an orally active and selective noradrenaline reuptake inhibitor. MCI-225 dehydratase also is a 5-HT3 antagonist and shows antidepressant effects in vivo.
-
SB399885 (Standard)
0 ImagesCat. No.: HY-105896RCAS No.: 402713-80-8SB399885 (Standard) is the analytical standard of SB399885 (HY-105896). This product is intended for research and analytical applications. SB399885 is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with pKi values 9.11 and 9.02 for human recombinant and native 5-HT6 receptors, respectively. SB399885 has cognitive enhancing properties.
-
SB 204741 (Standard)
0 ImagesCat. No.: HY-103153RCAS No.: 152239-46-8SB 204741 (Standard) is the analytical standard of SB 204741. This product is intended for research and analytical applications. SB 204741 is a selective and high affinity 5-HT2B antagonist with a pKi value of 7.1.
-
Xaliproden hydrochloride (Standard)
0 ImagesSynonyms: SR57746A (Standard); SR57746 hydrochloride (Standard)Xaliproden (hydrochloride) (Standard) is the analytical standard of Xaliproden (hydrochloride). This product is intended for research and analytical applications. Xaliproden (SR57746) hydrochloride (SR57746A) is an orally active, highly selective 5-HT1A receptor agonist. Xaliproden hydrochloride activates pertussis toxin-sensitive G protein-coupled signaling cascades, as well as the PKC, ERK1/ERK2, Akt and p21 Ras/MEK-1 pathways. Xaliproden hydrochloride also downregulates the JNK/p66/c-Jun signaling pathway, induces phosphorylation of the shc adaptor protein, regulates extracellular dopamine and 5-HT levels, and induces [35S]GTPγS labeling in rat brain structures rich in 5-HT1A receptors. Xaliproden hydrochloride exerts neurotrophic, neuroprotective, renoprotective, anti-inflammatory, anti-apoptotic, anti-fibrotic and analgesic effects. Xaliproden hydrochloride also enhances NGF-induced neurite outgrowth, promotes motor neuron survival, attenuates renal tubular injury and inhibits chemotherapy-induced mechanical allodynia, without activating or altering NGF-induced TrkA receptor activation. Xaliproden hydrochloride can be used in the research of motor neuron disease, diabetic nephropathy, chemotherapy-induced peripheral neuropathy, amyotrophic lateral sclerosis, Alzheimer's disease, acute tonic nociceptive pain, inflammatory pain, depression and anxiety.
-
Cinuperone
0 ImagesCat. No.: HY-W754019CAS No.: 82117-51-9Cinuperone is a multi-target competitive receptor ligand and σ receptor antagonist that acts on Dopamine D1, σ, Dopamine D1, and 5-HT2 receptors. Cinuperone shows significantly higher affinity for σ receptors than for Dopamine D1 receptors, and only exhibits moderate binding activity for dopamine D2 receptors. Cinuperone can be used in the research of central nervous system diseases.
-
Zalospirone
0 ImagesCat. No.: HY-169140CAS No.: 114298-18-9Synonyms: WY-47846Zalospirone (WY-47846) is a novel cyclic imide with 5-HT1A partial agonist activity. Zalospirone shows antidepressant efficacy.
-
Ziprasidone hydrochloride monohydrate (Standard)
0 ImagesCat. No.: HY-17407RCAS No.: 138982-67-9Synonyms: CP 88059 hydrochloride monohydrate (Standard)Ziprasidone (hydrochloride monohydrate) (Standard) is the analytical standard of Ziprasidone (hydrochloride monohydrate). This product is intended for research and analytical applications. Ziprasidone (CP-88059) hydrochloride monohydrate is an orally active combined 5-HT and dopamine receptor antagonist. Ziprasidone hydrochloride monohydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM).
-
Velusetrag (Standard)
0 ImagesSynonyms: TD-5108 (Standard)Velusetrag (Standard) is the analytical standard of Velusetrag (HY-10457). This product is intended for research and analytical applications. Velusetrag (TD-5108) is an orally active, potent and selective agonist of serotonin 5-HT4 receptor (5-HT4R), with a pKi of 7.7. Velusetrag exhibits no affinity (Ki>10 μM) for 5-HT2A and 5-HT2B receptors. Velusetrag can be used for the research of gastrointestinal diseases and Parkinson's disease.
