CDK Ligand

TAE648 is a target protein ligand of PROTAC SK-3-91 (HY-137341) (Ligand for Target Protein for PROTAC). TAE648 can be used for synthesis PROTAC. TAE648 decreases monolayer-cultured SKOV3ip1 cell viability.

Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (K_d) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439). HLB-0532259 shows anti-tumor activity against neuroblastoma.

PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.

N-Desmethyl FN-1501 (Compound 2) is a CDK2/9 ligand that can be used to synthesize PROTACs, such as PROTAC CDK2/9 Degrader-1 (HY-130709).

CDK2 ligand-2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC). CDK2 ligand-2 combined with E3 Ligase Ligand-linker Conjugate 184 (HY-176125) can be used to synthesize PROTAC degrader (CDK2 degrader 2 (HY-163815)).

CDK9 ligand 4 is a CDK9 ligand. As a ligand for target protein for PROTAC (Ligands for Target Protein for PROTAC), CDK9 ligand 4 serves for the development and design of PROTAC CDK9 degraders, such as PROTAC CDK9 degrader-12 (HY-181231). CDK9 ligand 4 is applicable to the research of HIV-1 infection.

CDK9 ligand 6 is a PROTAC target protein ligand targeting CDK9, which can be used in research related to PROTAC synthesis, such as serving as the target protein ligand for PROTAC CDK9 degrader-13 (HY-184693).

CDK12/13 ligand 4 is a CDK12/13 ligand that can be used for the synthesis of PROTACs, such as PROTAC CDK12/13 Degrader-1 (HY-151110).

CDK9 ligand-7 is a CDK9 ligand. CDK9 ligand-7 can serve as a target protein ligand for the synthesis of PROTAC CDK9 degraders, such as CP-07 (HY-149495). CDK9 ligand-7 can be used in prostate cancer research.

CDK12/13 ligand 3 is a CDK12/13 PROTAC ligand. CDK12/13 ligand 3 can be conjugated with E3 ligase ligand (HY-W093272) and linker to synthesize CDK12/13 PROTAC degrader DN1679 (HY-181035). CDK12/13 ligand 3 can be used for cancer research.

CDK9 ligand 5 (Compound 48) is a CDK9 ligand. CDK9 ligand 5 can be used as a ligand for target protein for PROTAC to develop and design degraders of PROTAC CDK9, such as PROTAC CDK9 degrader-9 (HY-168518). CDK9 ligand 5 can be used in cancer research.

CDK9 ligand 3 is the ligand for CDK9 and can be used for synthesis of PROTAC degrader PROTAC CDK9 degrader-11 (HY-170978).

CDK9 ligand-Linker Conjugate 1 is a compound formed by conjugation of a selective CDK9 ligand and a PROTAC linker. CDK9 ligand-Linker Conjugate 1 can be further coupled with an E3 ubiquitin ligase ligand to synthesize CDK9 PROTAC (HY-103628). CDK9 ligand-Linker Conjugate 1 is applicable to the research of CDK9-related disease states.

CDK7 ligand 3-CO-C5-COOH (compound 7) is a conjugate of CDK7 ligand and linker, which can be used for the synthesis of PROTAC TZ1104 (HY-183073).