Carbonic Anhydrase
Carbonate dehydratase
Carbonic anhydrase (CA) is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide: CO2 + H2O ⇋ HCO3- + H+. Eight genetically distinct carbonic anhydrase enzyme families (α-, β-, γ- δ-, ζ-, η-, θ- and ι- CAs) were described to date. Carbonic anhydrases are involved in numerous physiological and pathological processes. Many of them are important therapeutic targets with the potential to be inhibited to treat a range of disorders including oedema, glaucoma, obesity, cancer, epilepsy, and osteoporosis.
The carbonic anhydrase reaction is involved in many physiological and pathological processes, including respiration and transport of CO2 and bicarbonate between metabolizing tissues and lungs; pH and CO2 homeostasis; electrolyte secretion in various tissues and organs; biosynthetic reactions (such as gluconeogenesis, lipogenesis, and ureagenesis); bone resorption; calcification; and tumorigenicity. α-CAs are Zn2+ metalloproteins expressed in animals, vertebrates, prokaryotes, fungi, algae, protozoa, and plants. Sixteen mammalian α-CA isoforms are known to be involved in many diseases such as glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, arthritis, neurodegeneration, etc.
Carbonic Anhydrase Isoform Specific Products
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Carbonic Anhydrase
(193)
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CA
(7)
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CA I
(68)
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CA Ⅱ
(120)
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CA IX
(106)
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CA XII
(64)
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CA VII
(1)
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CA VI
(2)
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CA VA
(2)
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CA VB
(2)
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CA XIII
(2)
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CA XIV
(2)
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All Product Categories
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Carbonic Anhydrase Inhibitors
(342)
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Carbonic Anhydrase Activators
(6)
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Carbonic Anhydrase Modulators
(4)
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Carbonic Anhydrase Degrader
(1)
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Carbonic Anhydrase Ligands
(3)
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Carbonic Anhydrase Proteins
(33)
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Carbonic Anhydrase 1 (CA1) Proteins
(1)
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Carbonic Anhydrase 2 (CA-II) Proteins
(3)
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Carbonic Anhydrase 4 (CA IV) Proteins
(3)
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Carbonic Anhydrase 12 (CA-XII) Proteins
(1)
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Carbonic Anhydrase Related Products (382)
Related Products (382)
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Recombinant Proteins (33)
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Carbonic Anhydrase Isoform Comparison
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CA IX/GPX4-IN-1
0 ImagesCat. No.: HY-178475CA IX/GPX4-IN-1 (Compound 22abcb) is a dual targeted inhibitor of CA IX and GPX4 activity. CA IX/GPX4-IN-1 can effectively kill SUM159PT cells (IC50 = 416 nM) by inducing iron death under hypoxic conditions. CA IX/GPX4-IN-1 has an IC50 of 663 nM to CA IX in SUM159PT-CAIX-FL cells. CA IX/GPX4-IN-1 can significantly inhibit tumor growth and can be reversed by ferroptosis inhibitors. CA IX/GPX4-IN-1 can be used for research on breast cancer and other cancers.
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Carbonic anhydrase II, Human
0 ImagesCat. No.: HY-E71035ACarbonic anhydrase II, Human (EC 4.2.1.1) catalyzes the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa) , a reversible reaction that occurs relatively slowly in the absence of a catalyst.
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hBChE-IN-3
0 ImagesCat. No.: HY-169162hBChE-IN-3 (compound 30) is a combination of carbonic anhydrase (CA) activator and cholinesterase (ChE) inhibitor with IC50 values of 7.4 and 1.9 nM for AchE and BchE, respectively. hBChE-IN-3 can be used in the study of neurodegeneration and psychiatric disorders.
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hCAXII-IN-8
0 ImagesCat. No.: HY-161286hCAXII-IN-8 (compound 5r) is a potent carbonic anhydrase hCA XII inhibitor.
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CA-II/Dkk1-IN-1
0 ImagesCat. No.: HY-175219CA-II/Dkk1-IN-1 (Compound 5d) is a dual-functional inhibitor of CA-II and Dkk1 with a IC50 of 6.90 nM for CA-II. CA-II/Dkk1-IN-1 has significantly antioxidant activity and superior DNA binding capacity. CA-II/Dkk1-IN-1 can be used for cancers research, such as esophageal, renal, and lung cancer.
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hCAIX/XII-IN-9
0 ImagesCat. No.: HY-162063hCAIX/XII-IN-9 (compound 8) is a potent carbonic anhydrase (CA) inhibitor with Ki values of 1658 nM, 184.8 nM, 8.9 nM, 64.8 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively.
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Carbonic anhydrase/AChE-IN-2
0 ImagesCat. No.: HY-161143CAS No.: 3029817-13-5Carbonic anhydrase/AChE-IN-2 (compound 19) is a selective acetylcholinesterase (AChE) and carbonic anhydrase (CA) inhibitor, with Ei of 5.07 nM, 24.42 nM and 19.95 nM for AChE, hCAI and hCAII, respectively.
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ALP/Carbonic anhydrase-IN-1
0 ImagesALP/Carbonic anhydrase-IN-1 (Compound 1e) is a dual carbonic anhydrase (CA) and alkaline phosphatase (ALP) inhibitor. ALP/Carbonic anhydrase-IN-1 shows IC50 values of 0.44 µM, 1.61 µM, 0.51 µM, and 0.107 µM for CA-II, CA-IX, CA-XII, and ALP, respectively.
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CAIX-IN-18
0 ImagesCat. No.: HY-184789CAIX-IN-18 is a competitive carbonic anhydrase IX (CA IX) inhibitor with a Ki value of 1.76 μM. CAIX-IN-18 can be used for the research of colorectal cancer.
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CAI/II-IN-4
0 ImagesCat. No.: HY-147925CAS No.: 2480284-01-1CAI/II-IN-4 (compound 6d) is a potent dual hCA I/II inhibitor with Ki values of 16.95, 15.22 and 27.04 nM for hCA I, hCA II and hCA Ⅸ, respectively. CAI/II-IN-4 has anti-hypoxia activities and low toxicity. CAI/II-IN-4 can be used for acute mountain sickness (AMS) research.
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CAIX/XII-IN-18
0 ImagesCat. No.: HY-183591CAIX/XII-IN-18 is a selective human carbonic anhydrase IX/XII (CA IX/XII) inhibitor with Ki values of 28.1 nM (hCA IX) and 11.6 nM (hCA XII). CAIX/XII-IN-18 induces apoptosis in breast cancer cells. CAIX/XII-IN-18 can be used for the research of breast cancer, pancreatic cancer.
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CAI/II-IN-1
0 ImagesCat. No.: HY-146385CAS No.: 2422028-82-6CAI/II-IN-1 (Compound 3h) is a human carbonic anhydrase I and II (hCA I/II) inhibitor with IC50 values of 0.047 µM and 0.024 µM against hCA I and hCA II, respectively.
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hCAII-IN-2
0 ImagesCat. No.: HY-146355CAS No.: 2408599-78-8hCAII-IN-2 (Compound 11f) is a cytosolic human carbonic anhydrase (hCA) inhibitor with Ki values of 261.4, 3.8, 19.6 and 45.2 nM against hCA I, hCA II, hCA IX and hCA XII, respectively.
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HCAIX-IN-1
0 ImagesCat. No.: HY-146206CAS No.: 2389034-65-3HCAIX-IN-1 is a selective HCAIX inhibitor with a Ki value of 3.3 nM for hCA IX. HCAIX-IN-1 can be used in the study of solid tumors.
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Trichlormethiazide sodium
0 ImagesCat. No.: HY-B0235ACAS No.: 91996-54-2Trichlormethiazide sodium is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide sodium increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model.
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Dorzolamide hydrochloride (Standard)
0 ImagesSynonyms: L671152 hydrochloride(Standard); MK507 hydrochloride (Standard)Dorzolamide (hydrochloride) (Standard) is the analytical standard of Dorzolamide (hydrochloride). This product is intended for research and analytical applications. Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity.
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Benzenesulphonamide (Standard)
0 ImagesBenzenesulphonamide (Standard) is the analytical standard of Benzenesulphonamide (HY-101087). This product is intended for research and analytical applications. Benzenesulphonamide (Compound 1) is a carbonic anhydrase inhibitor. Benzenesulphonamide exhibits CA II inhibitory activity. Benzenesulphonamide reduces ROS and improves the gene expression of amyloid-β40 and 42. Benzenesulphonamide is beneficial for Alzheimer's disease. Benzenesulphonamide derivatives have anticancer, anti-inflammatory, and anticonvulsant activities. Benzenesulphonamide can be used in the research of Alzheimer's disease, epilepsy, inflammatory diseases, leukemia, melanoma, lung cancer, and colon cancer.
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Aminozolamide
0 ImagesCat. No.: HY-W566406CAS No.: 94641-11-9Aminozolamide is a carbonic anhydrase inhibitor. Aminozolamide regulates intraocular pressure by inhibiting carbonic anhydrase activity. Aminozolamide exerts local ocular effects, exhibits good retention in the ciliary body of rabbit eyes, and prevents rapid elimination from the eye. Aminozolamide is applicable to the research of ocular hypertension.
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Topiramate D12 (Standard)
0 ImagesCat. No.: HY-110234RCAS No.: 1279037-95-4Synonyms: McN 4853 D12 (Standard); RWJ 17021 D12 (Standard)Topiramate D12 (Standard) is the analytical standard of Topiramate D12. This product is intended for research and analytical applications. Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
