HSP
Heat shock proteins (HSPs) are molecular chaperones that support proteostasis by preventing protein misfolding and aggregation during nascent-chain folding and cellular stress[1]. Mechanistically, HSP70 acts upstream on nascent and newly synthesized polypeptides, while HSP90 supports folding and maturation of selected client proteins through coordinated chaperone cycles[1][2]. In cancer models, HSP90 buffers oncogenic signaling proteins and enables malignant cells to tolerate imbalanced signaling, making HSP90 inhibition a practical strategy for disrupting multiple client pathways[3][4]. Compared with ATP-dependent HSP70/HSP90 systems, HSP27/HSPB1 is a small heat shock protein whose oligomer-monomer dynamics regulate chaperone activity and whose redox-sensitive monomers suppress aggregation in vitro[5]. HSP27 also regulates apoptosis by interacting with cytochrome c and blocking downstream apoptotic complex formation, supporting its use in cell-death and stress-response experiments[6]. For experimental applications, HSP90 inhibitors provide tools to test client-protein dependence, while HSP27-focused assays can examine aggregation control, redox stress, and apoptosis regulation[4][5][6].
References:
- [1]. Hartl FU, et al. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science. 2002 Mar 8;295(5561):1852-8. [Content Brief]
- [2]. Dahiya V, et al. The switch from client holding to folding in the Hsp70/Hsp90 chaperone machineries is regulated by a direct interplay between co-chaperones. Mol Cell. 2022 Apr 21;82(8):1543-1556.e6. [Content Brief]
- [3]. Whitesell L, et al. HSP90 and the chaperoning of cancer. Nat Rev Cancer. 2005 Oct;5(10):761-72. [Content Brief]
- [4]. Neckers L, et al. Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res. 2012;18(1):64-76.
- [5]. Alderson TR, et al. Local unfolding of the HSP27 monomer regulates chaperone activity. Nat Commun. 2019 Mar 6;10(1):1068. [Content Brief]
- [6]. Bruey JM, et al. Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol. 2000 Sep;2(9):645-52. [Content Brief]
All Product Categories
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HSP Related Products (239)
Related Products (239)
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Antibodies (7)
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Dihydroberberine (Standard)
0 ImagesDihydroberberine (Standard) is the analytical standard of Dihydroberberine. This product is intended for research and analytical applications. Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene (hERG) channel and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS (HY-116282C)-induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy.
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Malonganenone A
0 ImagesCat. No.: HY-126601CAS No.: 882403-69-2
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Iso-PU-H54
0 ImagesCat. No.: HY-103063CAS No.: 852030-37-6Iso-PU-H54 is a purine-scaffold Grp94 inhibitor with an IC50 of 1.63 μM.
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HSP90-IN-12
0 ImagesCat. No.: HY-147747CAS No.: 2408643-60-5Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of hsp90 related proteins in cells and inhibited hsp90 mediated protein refolding of luciferase in vitro.
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TRC051384 hydrochloride
0 ImagesCat. No.: HY-124109CAS No.: 1333327-56-2TRC051384 hydrochloride is a potent inducer of heat shock protein 70 (HSP70). TRC051384 hydrochloride exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 hydrochloride can be used for the research of ischemic stroke.
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Ethoxyquin (Standard)
0 ImagesEthoxyquin (Standard) is the analytical standard of Ethoxyquin. This product is intended for research and analytical applications. Ethoxyquin is an antioxidant which has been used in animal feed for many years and also an inhibitor of heat shock protein 90 (Hsp90).
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Hsp90-IN-43
0 ImagesCat. No.: HY-179343CAS No.: 164520-05-2Hsp90-IN-43 (Compound 12) is a Hsp90-TPR2A interaction inhibitor with an IC50 of 360 nM and a Kd of 928 nM. Hsp90-IN-43 effectively inhibits the proliferation of BT474 cells. Hsp90-IN-43 can be used for the study of breast cancer.
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HS-131
0 ImagesCat. No.: HY-122878CAS No.: 2143119-98-4HS-131, a near infrared dye tethered Hsp90 inhibitor, is able to detect oncogene-driven breast cancers, including multiple different molecular subtypes of human breast cancers.
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Sodium bicarbonate ringer's solution
0 ImagesCat. No.: HY-FL0002Synonyms: Bicarbonate Ringer's solutionSodium bicarbonate ringer's solution is a solution containing sodium bicarbonate and electrolytes such as sodium, magnesium, potassium, calcium and chloride, which can be used as a cell integrity protectant. It is used to replenish and correct extracellular fluid and to treat metabolic acidosis.
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BIIB021 mesylate
0 ImagesCat. No.: HY-10212ACAS No.: 1225041-97-3Synonyms: CNF2024 mesylateBIIB021 (CNF2024) mesylate is the mesylate of BIIB021 (HY-10212). BIIB021 is an orally active Hsp90 inhibitor. BIIB021 inhibits the proliferation of chronic myeloid leukemia (CML) cells, with IC50 values of K562, K562/G, 32Dp210, and 32Dp210-T315I cells are 513.99, 603.53, 110.08, and 148.07 nM, respectively. BIIB021 degrades BCR-ABL protein and inhibits the β-catenin/c-Myc pathway. BIIB021 can also induce autophagy in CML cells. BIIB021 can be used for the research of CML.
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Tamoxifen-d2
0 ImagesCat. No.: HY-13757AS2CAS No.: 3047060-10-3Synonyms: ICI 47699-d2; (Z)-Tamoxifen-d2; trans-Tamoxifen-d2Tamoxifen-d2 (ICI 47699-d2) is the deuterium labeled Tamoxifen (HY-13757A). Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757).
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HDAC/HSP90-IN-4
0 ImagesCat. No.: HY-146212These compounds have strong hdac and hsp90 inhibitory activities. Compound 20 (HDAC ic50 = 194 nm; Hsp90 α < b> Ic50 = 153 nm) and compound 26 ((HDAC ic50= 360 nm; Hsp90 α < b> Ic50 = 77 nm) shows the strongest HDAC and HSP90 α Inhibitory activity. Both compounds can induce hsp90 expression and down regulate hsp90 client proteins, which play an important role in regulating the survival and invasion of cancer cells.
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dPDL1-4
0 ImagesCat. No.: HY-174468dPDL1-4 is a potent and selective eHSPTAC eHSP90 PD-L1 degrader with DC50s of 7.77 μM and 6.52 μM in HeLa and B16F10 cells. dPDL1-4 bridges eHSP90 with the target protein, inducing lysosomal degradation. dPDL1-4 can degrade PD-L1 significantly and inhibits tumor growth. dPDL1-4 can be used for the study of cervical cancer and melanoma. ((Pink: eHSP90 ligand (HY-174476); Blue: PD-L1 ligand (HY-116274); Black: Linker (HY-W021787); HSP ligand + linker: HY-174799)).
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FKBP51-Hsp90-IN-2
0 ImagesCat. No.: HY-158131CAS No.: 601511-07-3FKBP51-Hsp90-IN-2 (Compound E08) is a selective FKBP51-Hsp90 protein-protein interaction inhibitor with IC50 values of 0.4 µM and 5 µM for FKBP51 and FKBP52, respectively. FKBP51-Hsp90-IN-2 also effectively stimulates cellular energy metabolism and neurite growth. FKBP51-Hsp90-IN-2 can be used in research on neurodegenerative diseases and cancer.
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6BrCaQ
0 ImagesCat. No.: HY-144830CAS No.: 954416-67-26BrCaQ is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity. 6BrCaQ can be used in the synthesis of 6BrCaQ-TPP conjugates.
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Alvespimycin (Standard)
0 ImagesSynonyms: 17-DMAG (Standard); KOS-1022 (Standard); NSC 707545 (Standard)Alvespimycin (Standard) is the analytical standard of Alvespimycin (HY-10389). This product is intended for research and analytical applications. Alvespimycin (17-DMAG) is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 nM.
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Palmitic acid-13C-1
0 ImagesCat. No.: HY-N0830S22CAS No.: 158045-29-5Palmitic acid-13C-1 is the 13C-labeled Palmitic acid (HY-N0830). Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model.
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Luminespib (Standard)
0 ImagesSynonyms: VER-52296 (Standard); AUY922 (Standard); NVP-AUY922 (Standard)Luminespib (Standard) is the analytical standard of Luminespib. This product is intended for research and analytical applications. Luminespib (VER-52296) is a potent HSP90 inhibitor with IC50s of 7.8 and 21 nM for HSP90α and HSP90β, respectively.
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BF844
0 ImagesCat. No.: HY-120726CAS No.: 1404506-35-9BF844 mitigate hearing loss associated with USH3 (usher syndrome type III) mutation CLRN1 (clarin-1)N48K. BF844 induces CLRN1N48K transportes to the plasma membrane. BF844 shows significantly preserves hearing in vivo.
