HSP
Heat shock proteins (HSPs) are molecular chaperones that support proteostasis by preventing protein misfolding and aggregation during nascent-chain folding and cellular stress[1]. Mechanistically, HSP70 acts upstream on nascent and newly synthesized polypeptides, while HSP90 supports folding and maturation of selected client proteins through coordinated chaperone cycles[1][2]. In cancer models, HSP90 buffers oncogenic signaling proteins and enables malignant cells to tolerate imbalanced signaling, making HSP90 inhibition a practical strategy for disrupting multiple client pathways[3][4]. Compared with ATP-dependent HSP70/HSP90 systems, HSP27/HSPB1 is a small heat shock protein whose oligomer-monomer dynamics regulate chaperone activity and whose redox-sensitive monomers suppress aggregation in vitro[5]. HSP27 also regulates apoptosis by interacting with cytochrome c and blocking downstream apoptotic complex formation, supporting its use in cell-death and stress-response experiments[6]. For experimental applications, HSP90 inhibitors provide tools to test client-protein dependence, while HSP27-focused assays can examine aggregation control, redox stress, and apoptosis regulation[4][5][6].
References:
- [1]. Hartl FU, et al. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science. 2002 Mar 8;295(5561):1852-8. [Content Brief]
- [2]. Dahiya V, et al. The switch from client holding to folding in the Hsp70/Hsp90 chaperone machineries is regulated by a direct interplay between co-chaperones. Mol Cell. 2022 Apr 21;82(8):1543-1556.e6. [Content Brief]
- [3]. Whitesell L, et al. HSP90 and the chaperoning of cancer. Nat Rev Cancer. 2005 Oct;5(10):761-72. [Content Brief]
- [4]. Neckers L, et al. Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res. 2012;18(1):64-76.
- [5]. Alderson TR, et al. Local unfolding of the HSP27 monomer regulates chaperone activity. Nat Commun. 2019 Mar 6;10(1):1068. [Content Brief]
- [6]. Bruey JM, et al. Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol. 2000 Sep;2(9):645-52. [Content Brief]
All Product Categories
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HSP Related Products (239)
Related Products (239)
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Antibodies (7)
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HSP90i
0 ImagesCat. No.: HY-174476CAS No.: 1472616-48-0HSP90i is a HSP90 inhibitor. HSP90i can be used as a drug intermediate to synthesize LYTACs, such as dPDL1-4 (HY-174468).
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KW-2478 hydrochloride
0 ImagesCat. No.: HY-13468ACAS No.: 819812-18-5KW-2478 hydrochloride is an HSP90 inhibitor (IC50 = 3.8 nM). KW-2478 hydrochloride inhibits the growth and induces apoptosis in chronic myeloid leukemia (CML) cells and liver cancer cells. KW-2478 hydrochloride weakens the BCR/ABL and MAPK signaling pathways, leading to increased p27 and p21 expression and decreased cyclin B1 expression. KW-2478 hydrochloride downregulates STAT3 expression. KW-2478 hydrochloride may be used in research on cancers such as CML and liver cancer.
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Tin(II) palmitate
0 ImagesCat. No.: HY-W127458CAS No.: 35104-88-2Synonyms: Hexadecanoic acid, tin(2+) saltTin(II) palmitate (Hexadecanoic acid, tin(2+) salt) is a long-chain saturated fatty acid commonly found in animals and plants. Tin(II) palmitate can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) in mouse granular cells. Tin(II) palmitate can be used to establish a model of cellular steatosis.
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Palmitic acid-d2-3
0 ImagesCat. No.: HY-N0830S16CAS No.: 83293-32-7Palmitic acid-d2-3 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
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STA-2842
0 ImagesCat. No.: HY-117051CAS No.: 1046490-67-8STA-2842 is an inhibitor of heat shock protein HSP90 with potential to inhibit autosomal dominant polycystic kidney disease (ADPKD). ADPKD is caused by inherited mutations in the PKD1 or PKD2 genes that abnormally activate multiple signaling proteins and pathways that regulate cell proliferation. STA-2842 can significantly reduce initial renal cyst formation and kidney growth in mice, and slow disease progression in mice with existing cysts.
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Hsp90β-IN-1
0 ImagesCat. No.: HY-175008Hsp90β-IN-1 (Compound 7b) is a selective biotinylated inhibitor of heat shock protein 90β (HSP90β) with an IC50 = 0.33 μM.
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DCB-3503
0 ImagesCat. No.: HY-111244CAS No.: 87302-58-7DCB-3503 is an allosteric modulator of heat shock cognate protein HSC70 and an inhibitor of Cyclin D1. DCB-3503 inhibits Cyclin D1 translation by allosterically modulating the ATPase and chaperone activities of HSC70. DCB-3503 may inhibit malignancies such as hepatocellular carcinoma or breast cancer with elevated expression of cyclin D1.
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SST0116CL1
0 ImagesCat. No.: HY-164399CAS No.: 1799802-29-1SST0116CL1 is a HSP90 inhibitor (IC50: 0.21 μM). SST0116CL1 binds to the ATP binding pocket of Hsp90, and interferes with Hsp90 chaperone function thus resulting in client protein (EGFR, CDK4 and AKT) degradation. SST0116CL1 induces degradation of Her2 in BT-474 cell (IC50: 0.2 μM). SST0116CL1 has antiproliferative activity and inhibits tumor growth. SST0116CL1 can be used for the study of leukemia, gastric and ovarian carcinoma.
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HSP90-IN-10
0 ImagesCat. No.: HY-144724CAS No.: 2881071-86-7
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HSP70-IN-3
0 ImagesCat. No.: HY-143400CAS No.: 2882053-89-4
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Androgen receptor degrader-6
0 ImagesCat. No.: HY-182809CAS No.: 1372688-55-5Androgen receptor degrader-6 is a blood-brain barrier-permeable AR degrader. Androgen receptor degrader-6 inhibits the chaperone activity of HSP27 and disrupts the HSP27-AR complex. Androgen receptor degrader-6 promotes the degradation of wild-type and mutant AR, reduces AR protein levels, and inhibits the growth of glioblastoma cells. Androgen receptor degrader-6 can be used in glioblastoma research.
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Anticancer agent 249
0 ImagesCat. No.: HY-162751Anticancer agent 249 (Compound 89) is an inhibitor for Hsp90β with IC50 of 16.5 μM in PC3MM2 cell. Anticancer agent 249 inhibits proliferation of cancer cells MCF-7, T47D, MDA-MB-231, MDA-MB-468 and SKBr3 with IC50 of 1.8-5.3 μM. Anticancer agent 249 induces apoptosis in MDA-MB-231. Anticancer agent 249 exhibits antitumor efficacy in mice.
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Monorden diacetate
0 ImagesCat. No.: HY-167731CAS No.: 100262-15-5Monorden diacetate serves as a promising lead compound in the development of novel fungicides due to its potential as an Hsp90 inhibitor.
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Aha1/Hsp90-IN-2
0 ImagesCat. No.: HY-179377Aha1/Hsp90-IN-2 is a selective inhibitor of the Hsp90/Aha1 interaction, with its IC50 being 1.46 μM. Aha1/Hsp90-IN-2 inhibits the activation of Hsp90 ATPase activity mediated by Aha1 by specifically blocking the binding of Hsp90 to Aha1, thereby reducing tau protein aggregation. Aha1/Hsp90-IN-2 can be used for the study of neurodegenerative diseases, such as Alzheimer's disease.
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NSC-134754
0 ImagesCat. No.: HY-123303CAS No.: 75041-32-6Synonyms: NZ-28NSC-134754 (NZ-28) is a dehydroemetine derivative and heat shock protein (HSP) induction inhibitor. NSC-134754 acts at the post-transcriptional level, targets Hsp72 and Hsp27, and does not alter general protein synthesis, HSF-1 transcriptional activity, or Hsp mRNA levels. NSC-134754 can be used for the research of multiple myeloma, prostate carcinoma, colon carcinoma.
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CPUY201112
0 ImagesCat. No.: HY-111524CAS No.: 1860793-58-3CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research.
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HSP90i-COCH2CH2-PEG4-NHBoc
0 ImagesCat. No.: HY-174799HSP90i-COCH2CH2-PEG4-NHBoc is a conjugate of the HSP90 Ligand (HY-174476) and the linker (HY-W021787). HSP90i-COCH2CH2-PEG4-NHBoc can be used for synthesis of LYTACs, such as dPDL1-4 (HY-174468).
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Hsp90-IN-36
0 ImagesCat. No.: HY-170328Hsp90-IN-36 (compound 5) is a Hsp90 inhibitor with anticancer activity (MCF-7, IC50=14.74 μM).
