Integrin
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Integrin Inhibitors
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Integrin Ligands
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Integrin Related Products (379)
Related Products (379)
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Anti-Mouse CD11b Antibody (5C6)
0 ImagesCat. No.: HY-P991773Anti-Mouse CD11b Antibody (5C6) is a CD11b blocking antibody. Anti-Mouse CD11b Antibody (5C6) can be used for in vitro inhibition of myelomonocytic cell adhesion and in vivo inhibition of inflammatory cell recruitment. Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682).
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L-738167
0 ImagesCat. No.: HY-118410CAS No.: 163212-43-9L-738167 is an orally active fibrogen receptor antagonist that prevents the binding of fibrinogen to GP IIb/IIIa. L-738167 can be utilized in thrombus research.
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GRGDSPK TFA
0 ImagesCat. No.: HY-P0322ASynonyms: EMD 56574 TFAGRGDSPK TFA (EMD 56574 TFA) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK TFA is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK TFA is used to study the role of integrins in bone formation and resorption.
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Ac-RGDS-NH2
0 ImagesCat. No.: HY-P11416CAS No.: 122207-62-9Ac-RGDS-NH2, a tetrapeptide, is an integrin antagonist. Ac-RGDS-NH2 competitively binds to the GPIIb/IIIa receptor (Ki = 4.2 μM), inhibiting the binding of fibrinogen to platelets and thereby effectively suppressing platelet aggregation. Ac-RGDS-NH2 can be used for research on thrombosis.
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Lamifiban TFA
0 ImagesCat. No.: HY-111348ACAS No.: 144412-50-0Lamifiban TFA is a nonpeptide glycoprotein IIb/IIIa receptor and platelet aggregation antagonist. Lamifiban TFA in combination with thrombolytic therapy effectively restores coronary arterial patency. Lamifiban TFA is promising for research of acute coronary syndromes.
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SD3A
0 ImagesCat. No.: HY-179302CAS No.: 104260-74-4SD3A is an antiplatelet agent. SD3A inhibits granule secretion and GP IIb/IIIa activation. SD3A inhibits mitochondrial function. SD3A has an antiaggregant effect on washed platelets stimulated with Collagen. SD3A results in reduced thrombus formation without affecting coagulation.
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Gly-Arg-Gly-Asp-Ser TFA
0 ImagesCat. No.: HY-P0295ACAS No.: 2828433-23-2Synonyms: GRGDS TFAGly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ∼5 and ∼6.5 μM.
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GR83895
0 ImagesCat. No.: HY-P1702CAS No.: 152323-73-4GR83895 is a RGD based peptide, and inhibits ADP-induced platelet aggregation of human gel-filtered platelets (IC50= 0.9 μM).
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Anti-Integrin α9 Antibody
0 ImagesCat. No.: HY-P992049
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Eptifibatide monoacetate
0 ImagesCat. No.: HY-B0686ACAS No.: 1248559-53-6Eptifibatide monoacetate is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor, with anti-platelet activity.
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PDI-IN-4
0 ImagesCat. No.: HY-170655CAS No.: 3104129-77-0PDI-IN-4 is a highly selective inhibitor of human PDI (IC50=0.48 μM) with no significant cytotoxicity. PDI-IN-4 binds to PDI in a reversible manner, not only forming a covalent bond with the Cys400 residue but also engaging in hydrophobic interactions with other residues. By inhibiting the activation of GPIIb/IIIa, PDI-IN-4 effectively blocks platelet aggregation and thrombus formation. PDI-IN-4 can serve as an important tool reagent for thrombosis-related research.
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SP-8008
0 ImagesCat. No.: HY-138019CAS No.: 2088247-61-2SP-8008 is a selective shear stress-induced platelet aggregation (SIPA) inhibitor with an IC50 of 1.44 μM. SP-8008 effectively interferes von Willebrand factor (vWF) and platelet glycoprotein (GP) Ib interaction. SP-8008 exerts its antithrombotic effect by selectively inhibiting shear stress-induced platelet aggregation.
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Ac-MRGDH-NH2
0 ImagesCat. No.: HY-P10667Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. Ac-MRGDH-NH2 can be used to synthesize the diastereoisomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic bis-aqua ruthenium warhead [Ru(Ph2phen)2(OH2)2]2+, and Ac-MRGDH-NH2 possesses integrin targeting ability and photosubstitution properties. Therefore, Ac-MRGDH-NH2 can be utilized in research on tumor-targeted photodynamic activation chemotherapy (PACT).
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NM-001
0 ImagesCat. No.: HY-178819NM-001 is a theranostic prodrug that targets ανβ3 integrin. NM-001 consists of cRGD and GFLG peptides, a DCM fluorophore and Chlorambucil (HY-13593). NM-001 internalizes into lysosomes of tumor cells via the cRGD peptide, and generates NM-002 (HY-178820) and Chlorambucil through intracellular cleavage at the GFLG peptide by overexpressed Cathepsin B (CTSB). NM-001 exhibits green fluorescence under physiological conditions, and converts to NIR fluorescence by CTSB activation. NM-001 has significant antitumor activity with low toxicity in HeLa cell xenografts mouse models. NM-001 can be used for real-time drug release monitoring research.
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MLN2201
0 ImagesCat. No.: HY-P991604Synonyms: YFC51.1; LDP-01MLN2201 is a humanized monoclonal antibody inhibitor, targeting Integrin β2. MLN2201 inhibits the reperfusion injury after stroke and can be used for inflammatory diseases like ischemic stroke research.
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Lamifiban
0 ImagesCat. No.: HY-111348CAS No.: 144412-49-7Synonyms: Ro 44-9883Lamifiban is a nonpeptide glycoprotein IIb/IIIa receptor and platelet aggregation antagonist. Lamifiban in combination with thrombolytic therapy effectively restores coronary arterial patency. Lamifiban is promising for research of acute coronary syndromes.
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Adxanthromycin A
0 ImagesCat. No.: HY-N14915CAS No.: 223740-97-4Adxanthromycin A, a microbial metabolite, is a ICAM-1/LFA-1 mediated cell adhesion inhibitor.
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Anti-CD54/ICAM-1 Antibody (R6-5-D6)
0 ImagesCat. No.: HY-P990857Anti-CD54/ICAM-1 Antibody (R6-5-D6) is a kind of mouse IgG2a chimeric antibody inhibitor, targeting to human CD54/ICAM-1. Anti-CD54/ICAM-1 Antibody (R6-5-D6) can block CD54 binding to its ligand Lymphocyte Function-Associated Antigen 1 (LFA-1). Anti-CD54/ICAM-1 Antibody (R6-5-D6) can be used for the researches of inflammation and immunology.
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Cyclo(-RGDfK), 5/6 FAM labeled TFA
0 ImagesCat. No.: HY-P0023F1Cyclo(-RGDfK), 5/6 FAM labeled TFA is a Cyclo(-RGDfK) TFA (HY-P0023A) labeled with 5/6 FAM. Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface.
